ID G3QIG9_GORGO Unreviewed; 371 AA.
AC G3QIG9;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 43.
DE SubName: Full=Cell division cycle 73 {ECO:0000313|Ensembl:ENSGGOP00000002179.3};
GN Name=CDC73 {ECO:0000313|Ensembl:ENSGGOP00000002179.3};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000002179.3, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000002179.3, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000002179.3, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000002179.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the CDC73 family.
CC {ECO:0000256|ARBA:ARBA00010427}.
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DR EMBL; CABD030008020; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030008021; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030008022; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030008023; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030008024; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G3QIG9; -.
DR Ensembl; ENSGGOT00000002225.3; ENSGGOP00000002179.3; ENSGGOG00000002210.3.
DR GeneTree; ENSGT00390000001114; -.
DR HOGENOM; CLU_025849_0_1_1; -.
DR Proteomes; UP000001519; Chromosome 1.
DR Bgee; ENSGGOG00000002210; Expressed in testis and 5 other cell types or tissues.
DR GO; GO:0016593; C:Cdc73/Paf1 complex; IEA:InterPro.
DR GO; GO:0006368; P:transcription elongation by RNA polymerase II; IEA:InterPro.
DR Gene3D; 3.40.50.11990; RNA polymerase II accessory factor, Cdc73 C-terminal domain; 1.
DR InterPro; IPR007852; Cdc73/Parafibromin.
DR InterPro; IPR031336; CDC73_C.
DR InterPro; IPR038103; CDC73_C_sf.
DR InterPro; IPR032041; Cdc73_N.
DR PANTHER; PTHR12466; CDC73 DOMAIN PROTEIN; 1.
DR PANTHER; PTHR12466:SF8; PARAFIBROMIN; 1.
DR Pfam; PF05179; CDC73_C; 1.
DR Pfam; PF16050; CDC73_N; 1.
PE 3: Inferred from homology;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW Transcription {ECO:0000256|ARBA:ARBA00023163}.
FT DOMAIN 2..165
FT /note="Paf1 complex subunit Cdc73 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16050"
FT DOMAIN 197..360
FT /note="Cell division control protein 73 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF05179"
FT REGION 158..199
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 158..180
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 371 AA; 42303 MW; 9AD0DF68FD4838E9 CRC64;
TENIPVVRRP DRKDLLGYLN GEASTSASID RSAPLEIGLQ RSTQVKRAAD EVLAEAKKPR
IEDEECVRLD KERLAARLEG HKEGIVQTEQ IRSLSEAMSV EKIAAIKAKI MAKKRSTIKT
DLDDDITALK QRSFVDAEVD VTRDIVSRER VWRTRTTILQ STGKEGASAR KTQTPAAQPV
PRPVSQARPP PNQKKGSRTP IIIIPAATTS LITMLNAKDL LQDLKFVPSD EKKKQGCQRE
NETLIQRRKD QMQPGGTAIS VTVPYRVVDQ PLKLMPQDWD RVVAVFVQGP AWQFKGWPWL
LPDGSPVDIF AKIKAFHLKY DEVRLDPNVQ KWDVTVLELS YHKRHLDRPV FLRFWETLDR
YMVKHKSHLR F
//
