ID G3QIQ5_GORGO Unreviewed; 718 AA.
AC G3QIQ5;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 73.
DE SubName: Full=Kelch like family member 4 {ECO:0000313|Ensembl:ENSGGOP00000002271.2};
GN Name=KLHL4 {ECO:0000313|Ensembl:ENSGGOP00000002271.2};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000002271.2, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000002271.2, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000002271.2, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000002271.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
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DR EMBL; CABD030126446; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030126447; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030126448; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_004064515.1; XM_004064467.2.
DR AlphaFoldDB; G3QIQ5; -.
DR STRING; 9593.ENSGGOP00000002271; -.
DR Ensembl; ENSGGOT00000002321.3; ENSGGOP00000002271.2; ENSGGOG00000002307.3.
DR GeneID; 101138244; -.
DR KEGG; ggo:101138244; -.
DR CTD; 56062; -.
DR eggNOG; KOG4441; Eukaryota.
DR GeneTree; ENSGT00940000159818; -.
DR HOGENOM; CLU_004253_12_0_1; -.
DR InParanoid; G3QIQ5; -.
DR OMA; RTGHQSW; -.
DR OrthoDB; 5472491at2759; -.
DR TreeFam; TF329218; -.
DR Proteomes; UP000001519; Chromosome X.
DR Bgee; ENSGGOG00000002307; Expressed in testis and 5 other cell types or tissues.
DR GO; GO:0034451; C:centriolar satellite; IEA:Ensembl.
DR CDD; cd18510; BACK_KLHL4; 1.
DR Gene3D; 1.25.40.420; -; 1.
DR Gene3D; 2.120.10.80; Kelch-type beta propeller; 2.
DR InterPro; IPR011705; BACK.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR011043; Gal_Oxase/kelch_b-propeller.
DR InterPro; IPR015915; Kelch-typ_b-propeller.
DR InterPro; IPR006652; Kelch_1.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR PANTHER; PTHR24412; KELCH PROTEIN; 1.
DR PANTHER; PTHR24412:SF74; KELCH-LIKE PROTEIN 4; 1.
DR Pfam; PF07707; BACK; 1.
DR Pfam; PF00651; BTB; 1.
DR Pfam; PF01344; Kelch_1; 6.
DR PRINTS; PR00501; KELCHREPEAT.
DR SMART; SM00875; BACK; 1.
DR SMART; SM00225; BTB; 1.
DR SMART; SM00612; Kelch; 6.
DR SUPFAM; SSF50965; Galactose oxidase, central domain; 1.
DR SUPFAM; SSF54695; POZ domain; 1.
DR PROSITE; PS50097; BTB; 1.
PE 4: Predicted;
KW Kelch repeat {ECO:0000256|ARBA:ARBA00022441};
KW Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 182..249
FT /note="BTB"
FT /evidence="ECO:0000259|PROSITE:PS50097"
FT REGION 46..69
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 46..65
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 718 AA; 80232 MW; 5CF2B5A4263B150D CRC64;
MSVSGKKEFD VKQILRLRWR WFSHPFQGST NTGSCLQQEG YEHRGTPVQG RLKSHSRDRN
GLKKSNSPVH HNILAPVPGP APAHQRAVQN LQQHNLIVHF QANEDTPKSV PEKNLFKEAC
EKRAQDLEMM ADDNIEDSTA RLDTQHSEDM NATRSEEQFH VINHAEQTLR KMENYLKEKQ
LCDVLLIAGH LRIPAHRLVL SAVSDYFAAM FTNDLLEAKQ EEVRMEGVDP NALNSLVQYA
YTGVLQLKED TIESLLAAAC LLQLTQVIDV CSNFLIKQLH PSNCLGIRSF GDAQGCTELL
NVAHKYTMEH FIEVIKNQEF LLLPANEISK LLCSDDINVP DEETIFHALM QWVGHDVQNR
QGELGMLLSY IRLPLLPPQL LADLETSSMF TGDLECQKLL MEAMKYHLLP ERRSMMQSPR
TKPRKSTVGA LYAVGGMDAM KGTTTIEKYD LRTNSWLHIG TMNGRRLQFG VAVIDNKLYV
VGGRDGLKTL NTVECFNPVG KIWTVMPPMS THRHGLGVAT LEGPMYAVGG HDGWSYLNTV
ERWDPEGRQW NYVASMSTPR STVGVVALNN KLYAIGGRDG SSCLKSMEYF DPHTNKWSLC
APMSKRRGGV GVATYNGFLY VVGGHDAPAS NHCSRLSDCV ERYDPKGDSW STVAPLSVPR
DAVAVCPLGD KLYVVGGYDG HTYLSTVESY DAQRNEWKEE VPVNIGRAGA CVVVVKLP
//
