GenomeNet

Database: UniProt
Entry: G3QIW8_GORGO
LinkDB: G3QIW8_GORGO
Original site: G3QIW8_GORGO 
ID   G3QIW8_GORGO            Unreviewed;      3057 AA.
AC   G3QIW8;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 2.
DT   12-AUG-2020, entry version 35.
DE   SubName: Full=Centromere protein F {ECO:0000313|Ensembl:ENSGGOP00000002339};
GN   Name=CENPF {ECO:0000313|Ensembl:ENSGGOP00000002339};
OS   Gorilla gorilla gorilla (Western lowland gorilla).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Gorilla.
OX   NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000002339, ECO:0000313|Proteomes:UP000001519};
RN   [1] {ECO:0000313|Ensembl:ENSGGOP00000002339, ECO:0000313|Proteomes:UP000001519}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Scally A.;
RT   "Insights into the evolution of the great apes provided by the gorilla
RT   genome.";
RL   Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSGGOP00000002339}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
RN   [3] {ECO:0000313|Ensembl:ENSGGOP00000002339, ECO:0000313|Proteomes:UP000001519}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=22398555; DOI=10.1038/nature10842;
RA   Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA   Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA   McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA   Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA   Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA   Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA   Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA   Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA   Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA   Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA   Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA   Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA   Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT   "Insights into hominid evolution from the gorilla genome sequence.";
RL   Nature 483:169-175(2012).
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DR   EMBL; CABD030008808; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030008809; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSGGOT00000002389; ENSGGOP00000002339; ENSGGOG00000002373.
DR   GeneTree; ENSGT00730000111187; -.
DR   HOGENOM; CLU_000551_0_0_1; -.
DR   Proteomes; UP000001519; Chromosome 1.
DR   Bgee; ENSGGOG00000002373; Expressed in testis and 5 other tissues.
DR   GO; GO:0005930; C:axoneme; IEA:Ensembl.
DR   GO; GO:0005813; C:centrosome; IEA:Ensembl.
DR   GO; GO:0036064; C:ciliary basal body; IEA:Ensembl.
DR   GO; GO:0097539; C:ciliary transition fiber; IEA:Ensembl.
DR   GO; GO:0000940; C:condensed chromosome outer kinetochore; IEA:Ensembl.
DR   GO; GO:0030496; C:midbody; IEA:Ensembl.
DR   GO; GO:0005635; C:nuclear envelope; IEA:Ensembl.
DR   GO; GO:0016363; C:nuclear matrix; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0045120; C:pronucleus; IEA:Ensembl.
DR   GO; GO:0000922; C:spindle pole; IEA:Ensembl.
DR   GO; GO:0070840; F:dynein complex binding; IEA:Ensembl.
DR   GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR   GO; GO:0008022; F:protein C-terminus binding; IEA:Ensembl.
DR   GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
DR   GO; GO:0008134; F:transcription factor binding; IEA:Ensembl.
DR   GO; GO:0001822; P:kidney development; IEA:Ensembl.
DR   GO; GO:0051310; P:metaphase plate congression; IEA:Ensembl.
DR   GO; GO:0000278; P:mitotic cell cycle; IEA:Ensembl.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:Ensembl.
DR   GO; GO:0015031; P:protein transport; IEA:Ensembl.
DR   GO; GO:0010389; P:regulation of G2/M transition of mitotic cell cycle; IEA:Ensembl.
DR   GO; GO:0016202; P:regulation of striated muscle tissue development; IEA:Ensembl.
DR   GO; GO:0021591; P:ventricular system development; IEA:Ensembl.
DR   InterPro; IPR043513; Cenp-F.
DR   InterPro; IPR018302; CenpF/LEK1_Rb-prot-bd.
DR   InterPro; IPR019513; Centromere_CenpF_leu-rich_rpt.
DR   InterPro; IPR018463; Centromere_CenpF_N.
DR   PANTHER; PTHR18874; PTHR18874; 3.
DR   Pfam; PF10490; CENP-F_C_Rb_bdg; 1.
DR   Pfam; PF10473; CENP-F_leu_zip; 3.
DR   Pfam; PF10481; CENP-F_N; 2.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001519}.
FT   DOMAIN          1..56
FT                   /note="CENP-F_N"
FT                   /evidence="ECO:0000259|Pfam:PF10481"
FT   DOMAIN          63..250
FT                   /note="CENP-F_N"
FT                   /evidence="ECO:0000259|Pfam:PF10481"
FT   DOMAIN          1836..1978
FT                   /note="CENP-F_leu_zip"
FT                   /evidence="ECO:0000259|Pfam:PF10473"
FT   DOMAIN          2074..2213
FT                   /note="CENP-F_leu_zip"
FT                   /evidence="ECO:0000259|Pfam:PF10473"
FT   DOMAIN          2256..2395
FT                   /note="CENP-F_leu_zip"
FT                   /evidence="ECO:0000259|Pfam:PF10473"
FT   DOMAIN          2912..2956
FT                   /note="CENP-F_C_Rb_bdg"
FT                   /evidence="ECO:0000259|Pfam:PF10490"
FT   REGION          154..179
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1610..1633
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1653..1689
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2834..2922
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2967..3057
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          13..54
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          107..134
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          223..327
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          329..356
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          361..444
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          466..558
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          566..593
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          601..628
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          668..688
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          775..816
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          842..932
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          972..1052
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1061..1102
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1139..1187
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1236..1263
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1492..1555
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1567..1589
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1733..1760
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1768..1788
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1833..1860
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1875..1909
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1913..1940
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1945..2021
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2050..2077
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2085..2221
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2236..2259
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2267..2410
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2418..2487
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2498..2627
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2632..2659
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2682..2716
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2724..2768
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2779..2806
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2814..2834
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        1665..1689
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2859..2896
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2972..3024
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   3057 AA;  351262 MW;  B40BE5E5E582F24D CRC64;
     MSWALEEWKE GLPTRALQKI QELEGQLDKL KKEKQQRQFQ LDSLEAALQK QKQKVPLKLW
     KEKNENQLER SQQAAQSADV SLNPCNTPQK IFTTPLTPSQ YYSGSKYEDL KEKYNKEVEE
     RKRLEAEVKA LQAKKASQTL PQATMNHRDI ARHQASSSVF SWQQEKTPSH LSSNSQKTPI
     RRDFSASYFS GEQEVTPSRS TLQIGKRDAN SSFFDNSSSP HLLDQLKAQN QELRNKINEL
     ELRLQGHEKE MKGQVNKFQE LQLQLEKAKV ELIEKEKVLN KCRDELVRTT AQYDQASTKY
     TALEQKLKKL TEDLSCQRQN AESARCSLEQ KIKEKEKEFQ EELSRQQRSF QTLDQECIQM
     KARLTQELQQ AKNMHNVLQA ELDKLTSVKQ QLENNLEEFK QKLYRAEQAF QASQIKENEL
     RRSMEEMKKE NNLLKSQSEQ KAREVCHLEA ELKNIKQCLN QSQNFAEEMK AKNTSQETML
     RDLREKINQQ ENSLTLEKLK LAVADLEKQR DCSQDLLKKR EHHIEQLNDK LSKTEKESKA
     LLSALELKKK EYEELKEEKT LFSCWKSENE KLLTQMESEK ENLQSKINHL ETCLKTQQIK
     SHEYNERVRT LEMDRENLSV EIRNLHNMLD SKSVEVETQK LAYVELQQKA EFSDQKHQKE
     IENMCLKTSQ LTGQVEDLEH KLQLLSNEIM DKDRCYQDLH AEYESLRDLL KSKDASLVTN
     EDHQRSLLGF DQQPAVHHSF ANIIGEQGSM PSERSECHLE ADQSPKNSAI LQNRVDSLEF
     SLESQKQMNS DLQKQCEELV QIKGEIEENL MKAEQMHQSF VAETSQRISK LQEDTSAHQN
     VVAETLSALE NKEKELQLLN DKLETEQAEI QELKKSNHLL EDSLKELQLL SETLSLEKKE
     MSSIISLNKR EIEELTQENG TLKEINASLN QEKMNLIQKS ESFANYVDER EKSISELSDQ
     YKQEKLILLQ RCEETGNAYE DLSQKYKAAQ EKNSELECLL NECTSLCENR KNELEQLKEA
     FAKEHQEFLT KLAFAEERNQ NLMLELETVQ QALRSEMTDN QNNSKSEADG LKQEIMTLKE
     EQNKMQKEVN DLLQENEQLM KVMKTKHECQ NLESEPIRNS LKERGSERNQ CNFKPQMDLE
     VKEISLDSYN AQLVQLEAML RNKELKLQES EKEKECLQHE LQTIRGDLET SNLQDMQSQE
     ISGLKDCEID AEEKYISGPH ELSTSQNDNA HLQCSLQTTM NKLNELEKIC EILQAEKYEL
     VTELNDSRSE CITATRKMAE EVGKLVNEVK ILNDDSGLLH GEVVEDIPGG EFGEQPNEQH
     PVSLAPLDES NSYEHLTLSD KEVQMHFAEL QEKFSSLQSE HKILHDQHCQ MSSKMSELQT
     YVDSLKAENL VLSTNLRNFQ GDLVKEMQLG LEEGLVPSLS SSCVPDSSSL SSLGDSSFYR
     ALLEQTGDMS LLSNLEGTVS ANQCSVDEVF CSSLQEENLT RKETPSAPAK GVEELESLCE
     VYRQSLEKLE EKMESQGIMK NKEIQELEQL LSSERQELDC LRKQYLSENE QWQQKLTSVT
     LEMESKLAAE KKQTEQLSLE LEVARLQLQG LDLSSRSLLG IDTEDAIQGR NESCDISKEH
     TSETTERTPK HDVHQICDKD AQQDLNLDIE KITETGAVKP TGECSGEQSP DTNYEPPGED
     KTQGSSECIS ELSFSGPNAL VPMDFLGNQE NIQNLQLRVK ETSNENLRLL HVIEDRERKV
     ESLLNEMKEL DSKLHLQEVQ LMTKIEACIE LEKIVGELKK ENSDLSEKLE YFSCDNQELL
     QRVETSEGLN SDLEMHADKS SREDIGDNVA KVNDSWKERF LDVENELSRI RSEKANIEHQ
     ALYLEADLEV VQTEKLCLEK DNENKQKVIA CLEEELSVVT SERNQLRGEL DTMSKKTMEL
     DQLSEKMKEK TQELESHQSE CLHCIQVAEA EVKEKTELLQ TLSSDVSELL KDKTHLQEKL
     QSLEKDSQAL SLTKCELENQ IAQLNKEKEL LVKESESLQA RLSESDYEKL NVSKALEAAL
     VEKGEFALRL SSTQEEVHQL RRGIEKLRVR IEADEKRQLH VAEKLKERER ENDSLKDKVE
     NLERELQMSE ENQELVILDA ENSKAEVETL KTQIEEMARS LKVFELDLVT LRSEKENLTK
     QIQEKQGQLS ELDKFLSSFK SLLEEKEQAE IQIKEESKTA VEMLQNQLKE LNEAVAALCG
     DQEIMKATEQ SLDPPIEEEH QLRNSIEKLR ARLEADEKKQ LCVLQQLKES EHHADLLKGR
     VENLERELEI ARTNQEHAAL EAENSKGEVE TLKAKIEGMT QSLRDLELDL VTIRSEKENL
     TNELEKEQKR ISELEIINSS FENILQEKEQ EKVQMKEKSS TAMEMLQTQL KELNERVAAL
     HNDQEACKAK EQNLSSQVEC LELEKAQLLQ GLDEAKNNYI VLQSSVNGLI QEVENGKQKL
     EKKDEEISRL KNQVQDQEQL VSKLSQVEGE HQLWKEQNLE LRNLTVELEQ KIQVLQSKNA
     SLQDTLEVLQ SSYKNLENEL ELTKMNKMSF VEKVNKMTAK ETELQREMHE MAQKTAELQE
     ELSGEKNRLA GELQLLLEEI KSSKDQLKEL TLENSELKKS LDCMHKDQVE KEGKVREEIA
     EYQLRLHEAE KKHQALLLDT NKQYEVEIQI YREKLTSKEE CLSSQKLEID LLKSSKEELN
     NSLKATTQIL EELKKTKMDN LKYVNQLKKE NERAQGKMKL LIKSCKQLEE EKEILQKELS
     QLQAAQEKQK TGTVRDTKVD ELTTEIKELK ETLEEKTKEA DEYLDKYCSL LISHEKLEKA
     KEMLETQVAH LCSQQSKQDS RGSPLLDPVV PGPSPIPSVT EKRLSSGQNK ASGKRQRSSG
     IWENGRGPTP ATPESFSKKS KKAVMSGIHP AEDTEDTEFE PEGLPEVVKK GFADIPTGKT
     SPYIMRRTTM ATRTSPRLAA QKLALSPLSL GKENLAESSK PTAGGSRSQK VKVAQQSPVD
     SGTILREPTT KSFPVNNLPE RSPTDSPRES LRVKRGRLVP SPKAGLESKG SENCKVQ
//
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