ID G3QIW8_GORGO Unreviewed; 3057 AA.
AC G3QIW8;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 12-AUG-2020, entry version 35.
DE SubName: Full=Centromere protein F {ECO:0000313|Ensembl:ENSGGOP00000002339};
GN Name=CENPF {ECO:0000313|Ensembl:ENSGGOP00000002339};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000002339, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000002339, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000002339}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2011) to UniProtKB.
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000002339, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
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DR EMBL; CABD030008808; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030008809; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSGGOT00000002389; ENSGGOP00000002339; ENSGGOG00000002373.
DR GeneTree; ENSGT00730000111187; -.
DR HOGENOM; CLU_000551_0_0_1; -.
DR Proteomes; UP000001519; Chromosome 1.
DR Bgee; ENSGGOG00000002373; Expressed in testis and 5 other tissues.
DR GO; GO:0005930; C:axoneme; IEA:Ensembl.
DR GO; GO:0005813; C:centrosome; IEA:Ensembl.
DR GO; GO:0036064; C:ciliary basal body; IEA:Ensembl.
DR GO; GO:0097539; C:ciliary transition fiber; IEA:Ensembl.
DR GO; GO:0000940; C:condensed chromosome outer kinetochore; IEA:Ensembl.
DR GO; GO:0030496; C:midbody; IEA:Ensembl.
DR GO; GO:0005635; C:nuclear envelope; IEA:Ensembl.
DR GO; GO:0016363; C:nuclear matrix; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0045120; C:pronucleus; IEA:Ensembl.
DR GO; GO:0000922; C:spindle pole; IEA:Ensembl.
DR GO; GO:0070840; F:dynein complex binding; IEA:Ensembl.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0008022; F:protein C-terminus binding; IEA:Ensembl.
DR GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
DR GO; GO:0008134; F:transcription factor binding; IEA:Ensembl.
DR GO; GO:0001822; P:kidney development; IEA:Ensembl.
DR GO; GO:0051310; P:metaphase plate congression; IEA:Ensembl.
DR GO; GO:0000278; P:mitotic cell cycle; IEA:Ensembl.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:Ensembl.
DR GO; GO:0015031; P:protein transport; IEA:Ensembl.
DR GO; GO:0010389; P:regulation of G2/M transition of mitotic cell cycle; IEA:Ensembl.
DR GO; GO:0016202; P:regulation of striated muscle tissue development; IEA:Ensembl.
DR GO; GO:0021591; P:ventricular system development; IEA:Ensembl.
DR InterPro; IPR043513; Cenp-F.
DR InterPro; IPR018302; CenpF/LEK1_Rb-prot-bd.
DR InterPro; IPR019513; Centromere_CenpF_leu-rich_rpt.
DR InterPro; IPR018463; Centromere_CenpF_N.
DR PANTHER; PTHR18874; PTHR18874; 3.
DR Pfam; PF10490; CENP-F_C_Rb_bdg; 1.
DR Pfam; PF10473; CENP-F_leu_zip; 3.
DR Pfam; PF10481; CENP-F_N; 2.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000001519}.
FT DOMAIN 1..56
FT /note="CENP-F_N"
FT /evidence="ECO:0000259|Pfam:PF10481"
FT DOMAIN 63..250
FT /note="CENP-F_N"
FT /evidence="ECO:0000259|Pfam:PF10481"
FT DOMAIN 1836..1978
FT /note="CENP-F_leu_zip"
FT /evidence="ECO:0000259|Pfam:PF10473"
FT DOMAIN 2074..2213
FT /note="CENP-F_leu_zip"
FT /evidence="ECO:0000259|Pfam:PF10473"
FT DOMAIN 2256..2395
FT /note="CENP-F_leu_zip"
FT /evidence="ECO:0000259|Pfam:PF10473"
FT DOMAIN 2912..2956
FT /note="CENP-F_C_Rb_bdg"
FT /evidence="ECO:0000259|Pfam:PF10490"
FT REGION 154..179
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1610..1633
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1653..1689
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2834..2922
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2967..3057
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 13..54
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 107..134
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 223..327
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 329..356
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 361..444
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 466..558
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 566..593
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 601..628
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 668..688
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 775..816
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 842..932
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 972..1052
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1061..1102
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1139..1187
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1236..1263
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1492..1555
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1567..1589
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1733..1760
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1768..1788
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1833..1860
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1875..1909
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1913..1940
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1945..2021
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2050..2077
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2085..2221
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2236..2259
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2267..2410
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2418..2487
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2498..2627
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2632..2659
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2682..2716
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2724..2768
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2779..2806
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2814..2834
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1665..1689
FT /note="Polar"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2859..2896
FT /note="Polar"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2972..3024
FT /note="Polar"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3057 AA; 351262 MW; B40BE5E5E582F24D CRC64;
MSWALEEWKE GLPTRALQKI QELEGQLDKL KKEKQQRQFQ LDSLEAALQK QKQKVPLKLW
KEKNENQLER SQQAAQSADV SLNPCNTPQK IFTTPLTPSQ YYSGSKYEDL KEKYNKEVEE
RKRLEAEVKA LQAKKASQTL PQATMNHRDI ARHQASSSVF SWQQEKTPSH LSSNSQKTPI
RRDFSASYFS GEQEVTPSRS TLQIGKRDAN SSFFDNSSSP HLLDQLKAQN QELRNKINEL
ELRLQGHEKE MKGQVNKFQE LQLQLEKAKV ELIEKEKVLN KCRDELVRTT AQYDQASTKY
TALEQKLKKL TEDLSCQRQN AESARCSLEQ KIKEKEKEFQ EELSRQQRSF QTLDQECIQM
KARLTQELQQ AKNMHNVLQA ELDKLTSVKQ QLENNLEEFK QKLYRAEQAF QASQIKENEL
RRSMEEMKKE NNLLKSQSEQ KAREVCHLEA ELKNIKQCLN QSQNFAEEMK AKNTSQETML
RDLREKINQQ ENSLTLEKLK LAVADLEKQR DCSQDLLKKR EHHIEQLNDK LSKTEKESKA
LLSALELKKK EYEELKEEKT LFSCWKSENE KLLTQMESEK ENLQSKINHL ETCLKTQQIK
SHEYNERVRT LEMDRENLSV EIRNLHNMLD SKSVEVETQK LAYVELQQKA EFSDQKHQKE
IENMCLKTSQ LTGQVEDLEH KLQLLSNEIM DKDRCYQDLH AEYESLRDLL KSKDASLVTN
EDHQRSLLGF DQQPAVHHSF ANIIGEQGSM PSERSECHLE ADQSPKNSAI LQNRVDSLEF
SLESQKQMNS DLQKQCEELV QIKGEIEENL MKAEQMHQSF VAETSQRISK LQEDTSAHQN
VVAETLSALE NKEKELQLLN DKLETEQAEI QELKKSNHLL EDSLKELQLL SETLSLEKKE
MSSIISLNKR EIEELTQENG TLKEINASLN QEKMNLIQKS ESFANYVDER EKSISELSDQ
YKQEKLILLQ RCEETGNAYE DLSQKYKAAQ EKNSELECLL NECTSLCENR KNELEQLKEA
FAKEHQEFLT KLAFAEERNQ NLMLELETVQ QALRSEMTDN QNNSKSEADG LKQEIMTLKE
EQNKMQKEVN DLLQENEQLM KVMKTKHECQ NLESEPIRNS LKERGSERNQ CNFKPQMDLE
VKEISLDSYN AQLVQLEAML RNKELKLQES EKEKECLQHE LQTIRGDLET SNLQDMQSQE
ISGLKDCEID AEEKYISGPH ELSTSQNDNA HLQCSLQTTM NKLNELEKIC EILQAEKYEL
VTELNDSRSE CITATRKMAE EVGKLVNEVK ILNDDSGLLH GEVVEDIPGG EFGEQPNEQH
PVSLAPLDES NSYEHLTLSD KEVQMHFAEL QEKFSSLQSE HKILHDQHCQ MSSKMSELQT
YVDSLKAENL VLSTNLRNFQ GDLVKEMQLG LEEGLVPSLS SSCVPDSSSL SSLGDSSFYR
ALLEQTGDMS LLSNLEGTVS ANQCSVDEVF CSSLQEENLT RKETPSAPAK GVEELESLCE
VYRQSLEKLE EKMESQGIMK NKEIQELEQL LSSERQELDC LRKQYLSENE QWQQKLTSVT
LEMESKLAAE KKQTEQLSLE LEVARLQLQG LDLSSRSLLG IDTEDAIQGR NESCDISKEH
TSETTERTPK HDVHQICDKD AQQDLNLDIE KITETGAVKP TGECSGEQSP DTNYEPPGED
KTQGSSECIS ELSFSGPNAL VPMDFLGNQE NIQNLQLRVK ETSNENLRLL HVIEDRERKV
ESLLNEMKEL DSKLHLQEVQ LMTKIEACIE LEKIVGELKK ENSDLSEKLE YFSCDNQELL
QRVETSEGLN SDLEMHADKS SREDIGDNVA KVNDSWKERF LDVENELSRI RSEKANIEHQ
ALYLEADLEV VQTEKLCLEK DNENKQKVIA CLEEELSVVT SERNQLRGEL DTMSKKTMEL
DQLSEKMKEK TQELESHQSE CLHCIQVAEA EVKEKTELLQ TLSSDVSELL KDKTHLQEKL
QSLEKDSQAL SLTKCELENQ IAQLNKEKEL LVKESESLQA RLSESDYEKL NVSKALEAAL
VEKGEFALRL SSTQEEVHQL RRGIEKLRVR IEADEKRQLH VAEKLKERER ENDSLKDKVE
NLERELQMSE ENQELVILDA ENSKAEVETL KTQIEEMARS LKVFELDLVT LRSEKENLTK
QIQEKQGQLS ELDKFLSSFK SLLEEKEQAE IQIKEESKTA VEMLQNQLKE LNEAVAALCG
DQEIMKATEQ SLDPPIEEEH QLRNSIEKLR ARLEADEKKQ LCVLQQLKES EHHADLLKGR
VENLERELEI ARTNQEHAAL EAENSKGEVE TLKAKIEGMT QSLRDLELDL VTIRSEKENL
TNELEKEQKR ISELEIINSS FENILQEKEQ EKVQMKEKSS TAMEMLQTQL KELNERVAAL
HNDQEACKAK EQNLSSQVEC LELEKAQLLQ GLDEAKNNYI VLQSSVNGLI QEVENGKQKL
EKKDEEISRL KNQVQDQEQL VSKLSQVEGE HQLWKEQNLE LRNLTVELEQ KIQVLQSKNA
SLQDTLEVLQ SSYKNLENEL ELTKMNKMSF VEKVNKMTAK ETELQREMHE MAQKTAELQE
ELSGEKNRLA GELQLLLEEI KSSKDQLKEL TLENSELKKS LDCMHKDQVE KEGKVREEIA
EYQLRLHEAE KKHQALLLDT NKQYEVEIQI YREKLTSKEE CLSSQKLEID LLKSSKEELN
NSLKATTQIL EELKKTKMDN LKYVNQLKKE NERAQGKMKL LIKSCKQLEE EKEILQKELS
QLQAAQEKQK TGTVRDTKVD ELTTEIKELK ETLEEKTKEA DEYLDKYCSL LISHEKLEKA
KEMLETQVAH LCSQQSKQDS RGSPLLDPVV PGPSPIPSVT EKRLSSGQNK ASGKRQRSSG
IWENGRGPTP ATPESFSKKS KKAVMSGIHP AEDTEDTEFE PEGLPEVVKK GFADIPTGKT
SPYIMRRTTM ATRTSPRLAA QKLALSPLSL GKENLAESSK PTAGGSRSQK VKVAQQSPVD
SGTILREPTT KSFPVNNLPE RSPTDSPRES LRVKRGRLVP SPKAGLESKG SENCKVQ
//
