ID G3QL48_GORGO Unreviewed; 484 AA.
AC G3QL48;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=BPI fold containing family B member 1 {ECO:0000313|Ensembl:ENSGGOP00000003191.3};
GN Name=BPIFB1 {ECO:0000313|Ensembl:ENSGGOP00000003191.3};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000003191.3, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000003191.3, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000003191.3, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000003191.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; CABD030116463; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_018873016.1; XM_019017471.1.
DR AlphaFoldDB; G3QL48; -.
DR STRING; 9593.ENSGGOP00000003191; -.
DR Ensembl; ENSGGOT00000003264.3; ENSGGOP00000003191.3; ENSGGOG00000003242.3.
DR GeneID; 101129801; -.
DR KEGG; ggo:101129801; -.
DR CTD; 92747; -.
DR eggNOG; KOG4160; Eukaryota.
DR GeneTree; ENSGT01100000263546; -.
DR HOGENOM; CLU_050473_0_0_1; -.
DR InParanoid; G3QL48; -.
DR OMA; ELCPVIK; -.
DR OrthoDB; 5262309at2759; -.
DR TreeFam; TF338541; -.
DR Proteomes; UP000001519; Chromosome 20.
DR GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR GO; GO:0008289; F:lipid binding; IEA:InterPro.
DR GO; GO:0002227; P:innate immune response in mucosa; IBA:GO_Central.
DR GO; GO:0034144; P:negative regulation of toll-like receptor 4 signaling pathway; IBA:GO_Central.
DR CDD; cd00025; BPI1; 1.
DR InterPro; IPR017943; Bactericidal_perm-incr_a/b_dom.
DR InterPro; IPR021193; Bpifb1.
DR InterPro; IPR001124; Lipid-bd_serum_glycop_C.
DR InterPro; IPR017942; Lipid-bd_serum_glycop_N.
DR PANTHER; PTHR47395; BPI FOLD-CONTAINING FAMILY B MEMBER 1; 1.
DR PANTHER; PTHR47395:SF1; BPI FOLD-CONTAINING FAMILY B MEMBER 1; 1.
DR Pfam; PF01273; LBP_BPI_CETP; 1.
DR Pfam; PF02886; LBP_BPI_CETP_C; 1.
DR PIRSF; PIRSF037186; PLUNC_long_form; 1.
DR SMART; SM00328; BPI1; 1.
DR SUPFAM; SSF55394; Bactericidal permeability-increasing protein, BPI; 2.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..484
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014156332"
FT DOMAIN 36..257
FT /note="Lipid-binding serum glycoprotein N-terminal"
FT /evidence="ECO:0000259|SMART:SM00328"
SQ SEQUENCE 484 AA; 52524 MW; 2A1C2B217E6381FB CRC64;
MAGPWTFLLL CGLLAATLIQ ATLSPTAVLI LGPKVIKEKL TQELKDHNAT SNLQQLPLLS
AMREKPAGGI PVLGGLVNTV LKHIIWLKVI TANILQLQVK PSANDQELLV KIPLDMVAGF
NTPLVKTIVE FHMTTEAQAI VRMDTSASGP TRLVLSDCAT SHESLRIQLL HKLSFLVNAL
AKQVMNLLVP SLPNLVKNQL CPVIEASFNG MYADLLQLVK VPISLSIDRL EFDLLYPAIK
GDTIQLYLGA KLLDSQGKVT KWFNNSAASL TMPTLDNTPF SLIVSQDVVK AAVAAALPPE
EFMVLLDSVL PEIAHRLKSS IGLINEKAAD KLGSTQIVKI LTQDTPEFFI DQGRAKVAQL
IVLEVFPSSE ALRPLFTLGI EASSEAQFYT KGDQLILNLN NISSDRIQLM NSGIGWFQPD
VLKNIITEII HSILLPNQNG KLRSGVPVSL VKALGFEAAE SSLTKDALVL TPASLWKPTS
PVSQ
//
