ID G3QMP2_GORGO Unreviewed; 693 AA.
AC G3QMP2;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 73.
DE RecName: Full=protein-tyrosine-phosphatase {ECO:0000256|ARBA:ARBA00013064};
DE EC=3.1.3.48 {ECO:0000256|ARBA:ARBA00013064};
GN Name=PTPN22 {ECO:0000313|Ensembl:ENSGGOP00000003786.3};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000003786.3, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000003786.3, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000003786.3, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000003786.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non-
CC receptor class 4 subfamily. {ECO:0000256|ARBA:ARBA00034734}.
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DR EMBL; CABD030005448; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030005449; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G3QMP2; -.
DR STRING; 9593.ENSGGOP00000003786; -.
DR Ensembl; ENSGGOT00000003879.3; ENSGGOP00000003786.3; ENSGGOG00000003849.3.
DR eggNOG; KOG0789; Eukaryota.
DR GeneTree; ENSGT00940000160958; -.
DR HOGENOM; CLU_015557_1_0_1; -.
DR InParanoid; G3QMP2; -.
DR OMA; MMNQQSK; -.
DR TreeFam; TF351977; -.
DR Proteomes; UP000001519; Chromosome 1.
DR Bgee; ENSGGOG00000003849; Expressed in liver and 2 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0009898; C:cytoplasmic side of plasma membrane; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0019900; F:kinase binding; IEA:Ensembl.
DR GO; GO:0004726; F:non-membrane spanning protein tyrosine phosphatase activity; IBA:GO_Central.
DR GO; GO:0017124; F:SH3 domain binding; IEA:Ensembl.
DR GO; GO:0071225; P:cellular response to muramyl dipeptide; IEA:Ensembl.
DR GO; GO:0032715; P:negative regulation of interleukin-6 production; IEA:Ensembl.
DR GO; GO:0032717; P:negative regulation of interleukin-8 production; IEA:Ensembl.
DR GO; GO:0070433; P:negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway; IBA:GO_Central.
DR GO; GO:1903753; P:negative regulation of p38MAPK cascade; IBA:GO_Central.
DR GO; GO:0050868; P:negative regulation of T cell activation; IBA:GO_Central.
DR GO; GO:0032720; P:negative regulation of tumor necrosis factor production; IBA:GO_Central.
DR GO; GO:0035644; P:phosphoanandamide dephosphorylation; IEA:Ensembl.
DR GO; GO:2000566; P:positive regulation of CD8-positive, alpha-beta T cell proliferation; IBA:GO_Central.
DR GO; GO:0002230; P:positive regulation of defense response to virus by host; IBA:GO_Central.
DR GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IBA:GO_Central.
DR GO; GO:0071663; P:positive regulation of granzyme B production; IBA:GO_Central.
DR GO; GO:0032727; P:positive regulation of interferon-alpha production; IEA:Ensembl.
DR GO; GO:0032728; P:positive regulation of interferon-beta production; IEA:Ensembl.
DR GO; GO:1900227; P:positive regulation of NLRP3 inflammasome complex assembly; IEA:Ensembl.
DR GO; GO:0042307; P:positive regulation of protein import into nucleus; IEA:Ensembl.
DR GO; GO:1902523; P:positive regulation of protein K63-linked ubiquitination; IBA:GO_Central.
DR GO; GO:0034141; P:positive regulation of toll-like receptor 3 signaling pathway; IBA:GO_Central.
DR GO; GO:0034145; P:positive regulation of toll-like receptor 4 signaling pathway; IBA:GO_Central.
DR GO; GO:0034157; P:positive regulation of toll-like receptor 7 signaling pathway; IBA:GO_Central.
DR GO; GO:0034165; P:positive regulation of toll-like receptor 9 signaling pathway; IBA:GO_Central.
DR GO; GO:0002685; P:regulation of leukocyte migration; IEA:Ensembl.
DR GO; GO:1901222; P:regulation of non-canonical NF-kappaB signal transduction; IBA:GO_Central.
DR GO; GO:0030217; P:T cell differentiation; IBA:GO_Central.
DR GO; GO:0050852; P:T cell receptor signaling pathway; IBA:GO_Central.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 2.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR047170; PTN12/18/22.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR45983; TYROSINE PHOSPHATSE N18, PUTATIVE-RELATED; 1.
DR PANTHER; PTHR45983:SF1; TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 22; 1.
DR Pfam; PF00102; Y_phosphatase; 2.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00194; PTPc; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000001519}.
FT DOMAIN 24..136
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 137..166
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT REGION 543..586
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 546..573
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 693 AA; 78350 MW; 6E63732E6812E983 CRC64;
MDQREILQKF LDEAQSKKIT KEEFANEFLK LKRQSTKYKA DKTYPTTVAE KPKNIKKNRY
KDILPYDYSR VELSLITSDE DSSYINANFI KGVYGPKAYI ATQGPLSTTL LDFWRMIWEY
SVLIIVMACM EYEMGKIIPE NFSVFSLIRE MRTQRPSLVQ TQEQYELVYN AVLELFKRQM
DVIRDKHSGT ESQAKYCIPE KNHTLQADSY SPNLPKSTTK AAKMMNQQRT KMEIKESSSF
DFRTSEISAK EELVLHPAKS STSFDFLELN YGFDKNADAT MKWQTKAFPI VGEPLQKHQS
LDLGSLLSEG CSNSKPVNAA GRYFNSKVPI TRTKSTPFEL IQQRETKEVD SKENFSYLES
QPHDSCFVEM QAQKVMHVSS AELNYSLPYD SKHQIRNASN VKHHDSSALG VYSYIPLVEN
PYFSSWPPSG TSSKMSLDLP EKQDGTVFPS SLLPTSSTSL FSYYNSHDSL SLNSPTNISP
LLNQESAVLA TAPRIDDEIP PPLPVRTPES FIVVEEAGEF SPNVPKSLSS AVKVKIGTSL
EWGGTSEPKK FDDSVRLRPS KSVKLRSPKS ELHQDRSSPP PPLPERTLES FFLADEDCMQ
AQSIETYSTS YPVTMENSTS SKQTLKTPGK SFTRSKSLKI LRNMKKSICN SCPPNKPAES
VQSNNSSSFL NFGFANRFSK PKGPRNPPPT WNI
//
