ID G3QMQ6_GORGO Unreviewed; 329 AA.
AC G3QMQ6;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE RecName: Full=Sex comb on midleg-like protein 1 {ECO:0000256|ARBA:ARBA00040639};
GN Name=SCML1 {ECO:0000313|Ensembl:ENSGGOP00000003800.2};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000003800.2, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000003800.2, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000003800.2, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000003800.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Putative Polycomb group (PcG) protein. PcG proteins act by
CC forming multiprotein complexes, which are required to maintain the
CC transcriptionally repressive state of homeotic genes throughout
CC development. May be involved in spermatogenesis during sexual
CC maturation. {ECO:0000256|ARBA:ARBA00037060}.
CC -!- SIMILARITY: Belongs to the SCM family. {ECO:0000256|ARBA:ARBA00008469}.
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DR EMBL; CABD030123001; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_018875212.1; XM_019019667.1.
DR AlphaFoldDB; G3QMQ6; -.
DR Ensembl; ENSGGOT00000003894.3; ENSGGOP00000003800.2; ENSGGOG00000003874.3.
DR GeneID; 101148208; -.
DR CTD; 6322; -.
DR GeneTree; ENSGT00940000164589; -.
DR HOGENOM; CLU_964843_0_0_1; -.
DR InParanoid; G3QMQ6; -.
DR OMA; TIFYAYE; -.
DR OrthoDB; 4846858at2759; -.
DR Proteomes; UP000001519; Chromosome X.
DR Bgee; ENSGGOG00000003874; Expressed in liver and 6 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003682; F:chromatin binding; IBA:GO_Central.
DR GO; GO:0042393; F:histone binding; IBA:GO_Central.
DR GO; GO:0045892; P:negative regulation of DNA-templated transcription; IBA:GO_Central.
DR CDD; cd09578; SAM_Scm; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR047531; SAM_Scm-like.
DR PANTHER; PTHR47305; BEN DOMAIN-CONTAINING PROTEIN 2; 1.
DR PANTHER; PTHR47305:SF3; SAM DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00536; SAM_1; 1.
DR SMART; SM00454; SAM; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR PROSITE; PS50105; SAM_DOMAIN; 1.
PE 3: Inferred from homology;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW Repressor {ECO:0000256|ARBA:ARBA00022491}.
FT DOMAIN 258..306
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT REGION 138..157
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 138..156
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 329 AA; 37539 MW; FD4BEEC64B049119 CRC64;
MMSNSSSEID VVKTRIPTYD EDDDTILYAY ETKPEFVNKE PNIVSDASCN TEEQLKTVND
VLIHCQVIYD AMQNLDKKID VIRRKVSKIQ RFHARSLWTN RKRYGYKKHS YRLVKKLKLQ
KMKKNEVYET FSYPESYSPT LPVSRRENNS PSNLPRPSFC MEEYQRAEPE EDPILSRTLS
PVHPSDFSEH NYQPYYASDG AAYGSSSGLC LGNPRADSIH DTYSTDQASA APPSVTRSPF
ENDGYIEKGS ITKHPSTWSV EAVVLFLKQT DPLALCPLVD LFRSHEIDGK ALLLLTSDVL
LKHLGVKLGT AVKLCYYIDR LKQGKCFEN
//
