ID G3QQT3_GORGO Unreviewed; 354 AA.
AC G3QQT3;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE SubName: Full=GRAM domain containing 2A {ECO:0000313|Ensembl:ENSGGOP00000004957.2};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000004957.2, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000004957.2, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000004957.2, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000004957.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; CABD030097023; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_004056492.1; XM_004056444.2.
DR AlphaFoldDB; G3QQT3; -.
DR STRING; 9593.ENSGGOP00000004957; -.
DR Ensembl; ENSGGOT00000005084.3; ENSGGOP00000004957.2; ENSGGOG00000005059.3.
DR GeneID; 101136230; -.
DR KEGG; ggo:101136230; -.
DR CTD; 196996; -.
DR eggNOG; KOG1032; Eukaryota.
DR GeneTree; ENSGT00940000159572; -.
DR HOGENOM; CLU_050698_0_1_1; -.
DR InParanoid; G3QQT3; -.
DR OMA; GRWAWPM; -.
DR OrthoDB; 45896at2759; -.
DR TreeFam; TF327695; -.
DR Proteomes; UP000001519; Chromosome 15.
DR Bgee; ENSGGOG00000005059; Expressed in adult mammalian kidney and 2 other cell types or tissues.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:Ensembl.
DR GO; GO:0031234; C:extrinsic component of cytoplasmic side of plasma membrane; IBA:GO_Central.
DR GO; GO:0044232; C:organelle membrane contact site; IBA:GO_Central.
DR GO; GO:0005546; F:phosphatidylinositol-4,5-bisphosphate binding; IBA:GO_Central.
DR GO; GO:0061817; P:endoplasmic reticulum-plasma membrane tethering; IBA:GO_Central.
DR GO; GO:2001256; P:regulation of store-operated calcium entry; IBA:GO_Central.
DR CDD; cd13220; PH-GRAM_GRAMDC; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR004182; GRAM.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR042624; RAMD2A.
DR PANTHER; PTHR46973; GRAM DOMAIN-CONTAINING PROTEIN 2A; 1.
DR PANTHER; PTHR46973:SF1; GRAM DOMAIN-CONTAINING PROTEIN 2A; 1.
DR Pfam; PF02893; GRAM; 1.
DR SMART; SM00568; GRAM; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 312..332
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 72..139
FT /note="GRAM"
FT /evidence="ECO:0000259|SMART:SM00568"
FT REGION 1..46
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..29
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 32..46
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 354 AA; 40013 MW; 8534C37E4D23982B CRC64;
MTALSRSEAA EAGSNQQMHG KTASLNSPVS CKEKPDRVEE PPDYSLHWPE GLKGEEIKKC
GREGITLNKY NQQYHKLFKD VPLEEVVLKV CSCALQRDLL LQGRLYISPN WLCFHASLFG
KDIKVVIPVV SVQMIKKHKM ARLLPNGLAI TTKTSQKYIF VSLLSRDSVY DLLRRVCTHL
QPSSKKSLSV REFSGEPESL EVLIPEMKWR KVCPSSRSLS LPDNIPCIPP SSVDSTDSFF
PSRKPPMSEK SRAQVASENG GRWAWPMPGW GPACPKKMPN CSPTAKNAVY EEDKLEEEPR
STGELRLWDY RLLKVFFVLI CFLVMSSSYL AFRISRLEQQ LCSLSWDGPV PGHR
//