ID G3QTD7_GORGO Unreviewed; 742 AA.
AC G3QTD7;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 24-JAN-2024, entry version 59.
DE SubName: Full=LDL receptor related protein 3 {ECO:0000313|Ensembl:ENSGGOP00000005950.3};
GN Name=LRP3 {ECO:0000313|Ensembl:ENSGGOP00000005950.3};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000005950.3, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000005950.3, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000005950.3, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000005950.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane, coated pit
CC {ECO:0000256|ARBA:ARBA00037878}.
CC -!- SIMILARITY: Belongs to the LDLR family.
CC {ECO:0000256|ARBA:ARBA00009939}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00124}.
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DR EMBL; CABD030113108; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G3QTD7; -.
DR Ensembl; ENSGGOT00000006108.3; ENSGGOP00000005950.3; ENSGGOG00000006079.3.
DR GeneTree; ENSGT00940000160021; -.
DR Proteomes; UP000001519; Chromosome 19.
DR Bgee; ENSGGOG00000006079; Expressed in prefrontal cortex and 5 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd00041; CUB; 2.
DR CDD; cd00112; LDLa; 4.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 4.
DR Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 2.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR PANTHER; PTHR24270; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED; 1.
DR PANTHER; PTHR24270:SF22; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 3; 1.
DR Pfam; PF00431; CUB; 2.
DR Pfam; PF00057; Ldl_recept_a; 3.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00042; CUB; 2.
DR SMART; SM00192; LDLa; 5.
DR SUPFAM; SSF57424; LDL receptor-like module; 4.
DR SUPFAM; SSF49854; Spermadhesin, CUB domain; 2.
DR PROSITE; PS01180; CUB; 2.
DR PROSITE; PS01209; LDLRA_1; 3.
DR PROSITE; PS50068; LDLRA_2; 4.
PE 3: Inferred from homology;
KW Coated pit {ECO:0000256|ARBA:ARBA00023176};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00124}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 469..495
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 15..131
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 226..337
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT REGION 607..742
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 644..661
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 663..678
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 697..711
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 138..150
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 145..163
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 157..172
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 206..221
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 409..424
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 427..439
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 434..452
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 446..461
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
SQ SEQUENCE 742 AA; 80100 MW; F123EDAB357A0B24 CRC64;
PVVRVLLRGR AAAACSGKLE QHTERRGVIY SPAWPLNYPP GTNCSWYIQG DRGDMITISF
RNFDVEESHQ CSLDWLLLGP AAPPRQEAFR LCGSAIPPAF ISARDHVWIF FHSDASSSGQ
AQGFRLSYIR GKLGQASCQA DEFRCDNGKC LPGPWQCNTV DECGDGSDEG NCSAPASEPP
GSLCPGGTFP CSGARSTRCL PVERRCDGLQ DCGDGSDEAG CPDLACGRRL GSFYGSFASP
DLFGAARGPS DLHCTWLVDT QDSRRVLLQL ELRLGYDDYV QVYEGLGERG DRLLQTLSYR
SNHRPVSLEA AQGRLTVAYH ARARSAGHGF NATYQVKGYC LPWEQPCGSS SDSDGGSPGD
QGCFSEPQRC DGWWHCASGR DEQGCPACPP DQYPCEGGSG LCYTPADRCN NQKSCPDGAD
EKNCFSCQPG TFHCGTNLCI FETWRCDGQE DCQDGSDEHG CLAAVPRKVI TAALIGSLVC
GLLLVIALGC AFKLYSLRTQ EYRAFETQMT RLEAEFVRRE APPSYGQLIA QGLIPPVEDF
PVYSASQASV LQNLRTAMRR QMRRHASRRG PSRRRLGRLW NRLFHRPRAP RGQIPLLTAA
RPSQTVLGDG FLQPAPGAAP DPPAPLMDTG STRAAGDRPP SAPGRAPEVG PSGPPLPSGL
RDPECRPVDK DRKVCREPLA DGPAPADAPR EPCSAQDPHP QASTASSTLG PHSPEPLGVC
RNPPPTCSPM LEASDDEALL VC
//