ID G3QU23_GORGO Unreviewed; 1837 AA.
AC G3QU23;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=Ral GTPase activating protein catalytic subunit alpha 2 {ECO:0000313|Ensembl:ENSGGOP00000006211.3};
GN Name=RALGAPA2 {ECO:0000313|Ensembl:ENSGGOP00000006211.3};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000006211.3, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000006211.3, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000006211.3, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000006211.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; CABD030115861; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030115862; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030115863; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030115864; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030115865; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSGGOT00000006378.3; ENSGGOP00000006211.3; ENSGGOG00000006329.3.
DR eggNOG; KOG3686; Eukaryota.
DR GeneTree; ENSGT00950000183139; -.
DR HOGENOM; CLU_001676_0_0_1; -.
DR TreeFam; TF324484; -.
DR Proteomes; UP000001519; Chromosome 20.
DR Bgee; ENSGGOG00000006329; Expressed in liver and 6 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:InterPro.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-UniRule.
DR GO; GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.
DR Gene3D; 3.40.50.11210; Rap/Ran-GAP; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR035974; Rap/Ran-GAP_sf.
DR InterPro; IPR000331; Rap/Ran_GAP_dom.
DR InterPro; IPR046859; RGPA/RALGAPB_N.
DR InterPro; IPR027107; Tuberin/Ral-act_asu.
DR PANTHER; PTHR10063:SF2; RAL GTPASE-ACTIVATING PROTEIN SUBUNIT ALPHA-2; 1.
DR PANTHER; PTHR10063; TUBERIN; 1.
DR Pfam; PF20412; RALGAPB_N; 1.
DR Pfam; PF02145; Rap_GAP; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF111347; Rap/Ran-GAP; 1.
DR PROSITE; PS50085; RAPGAP; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468, ECO:0000256|PROSITE-
KW ProRule:PRU00165}; Reference proteome {ECO:0000313|Proteomes:UP000001519}.
FT DOMAIN 1599..1807
FT /note="Rap-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50085"
FT REGION 305..334
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 409..445
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 698..820
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 320..334
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 409..437
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 702..763
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 764..778
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 786..810
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1837 AA; 206567 MW; 5B1477E9CB0DC8AA CRC64;
NVDANDLKQF FETNYSQIYF IFYENFITLE NSLKLKGNNK SQREELDSIL FLFEKILQFL
PERIFFRWHY QSIGSTLKKL LHTGNSIKIR CEGIRLFLLW LQALQTNCAE EQVLIFACLV
PGFPAVMSSR GPCTLETLIN PSPSVADVKI YPEEITPLLP AISGEKIAED QTCFFLQILL
KYMVIQAASL EWKNKENQDT GFKFLFTLFR KYYLPHLFPS FTKLTNIYKP VLDIPHLRPK
PVYITTTRDN ENIYSTKIPY MAARVVFIKW IVTFFLEKKY LTATQNTKNG VDVLPKIIQT
VGGGAVQERA PELDGGGPTE QDKSHSNSST LSDRRLSNSS LCSIEEEHRM VYEMVQRILL
STRGYVNFVN EVFHQAFLLP SCEIAVTRKV VQVYRKWILQ DKPVFMEEPD RKDVAQEDAE
KLGFSETDSK EASSESSGHK RSSSWGRTYS FTSAMSRGCV TEEENTNVKA GVQALLQVFL
TNSANVFLLE PCAEVPVLLK EQVDACKAVL IIFRRMIMEL TMNKKTWEQM LQILLRITEA
VMQKPKDKQI KDLFAQSLAG LLFRTLMVAW IRANLCVYIS RELWDDFLGV LSSLTEWEEL
INEWANIMDS LTAVLARTVY GVEMTNLPLD KLSEQKEKKQ RGKGCVLDPQ KGTTVGRSFS
LSWRSHPDVT EPMRFRSATT SGAPGVEKAR NIVRQKATEV EECQQSENAP AAGSGHLTVG
QQQQVLRSSS TSDIPEPLCS DSSQGQKAEN TQNSSSSEPQ PIQENKGHVK REHEGITILV
RRSSSPAELD LKDDLQQTQG KCRERQKSES TNSDTTLGCT NEAELSMGPW QTCEEDPELN
TPTDVVADAD ARHWLQLSPT DASNLTDSSE CLTDDCSIIA GGSLTGWHPD SAAVLWRRVL
GILGDVNNIQ SPKIHARVFC YLYELWYKLA KIRDNLAISL DNQSSPSPPV LIPPLRMFAS
WLFKAATLPN EYKEGKLQAY RLICAMMTRR QDVLPNSDFL VHFYLVMHLG LTSEDQDILN
TIIRHCPPRF FSLGFPGFSM LVGDFITAAA RVLSTDMLTA PRSEAVTVLG SLVCFPNTYQ
EIPLLQSVPE VNEAITGTED VKHYLINILL KNATEEPNEY ARCIAVCSLG VWICEELAQC
TNHPQVKEAI NVIGVTLKFP NKIVAQVACD VLQLLVSYWE KLQMFETSLP RKMAEILVAT
IAFLLPSAEY SSVETDKKFI VSLLLCLLDW CMALPVSVLL HPVSTAILEE QHSARAPLLD
YIYRVLHCCV CGSSTYTQQS HYILTLADLS STDYDPFLPL ANVKSSEPVQ YHSSAELGNL
LTVEEEKKRR SLELIPLTAR MVMAHLVNHL GHYPLSGGPA ILHSLVSENH DNAHVEGSEL
SSEVFRSPNL QLFVFNDSTL ISYLQTPTEG PAGGSPVGSL SDVRVIVRDI SGKYSWDGKV
LYGPLEGCLA PNGRNPSFLI SSWHRDTFGP QKDSSQVEEG DDVLDKLLEN IGHTSPECLL
PSQLNLNEPS LPPCGMNYDQ EKEIIEVILR QNAQEDEYIQ SHNFDSAMKV TSQGQPSPVE
PRGPFYFCRL LLDDLGMNSW DRRKNFHLLK KNSKLLRELK NLDSRQCRET HKIAVFYIAE
GQEDKCSILS NERGSQAYED FVAGLGWEVD LSTHCGFMGG LQRNGSTGQT APYYATSTVE
VIFHVSTRMP SDSDDSLTKK LRHLGNDEVH IVWSEHSRDY RRGIIPTAFG DVSIIIYPMK
NHMFFIAITK KPEVPFFGPL FDGAIVSGKL LPSLVCATCI NASRAVKCLI PLYQSFYEER
ALYLEAIIQN HREVMTFEDF AAQVFSPSPS YSLSGTD
//
