ID G3QUP3_GORGO Unreviewed; 504 AA.
AC G3QUP3;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE RecName: Full=Tapasin {ECO:0000256|ARBA:ARBA00039535};
DE AltName: Full=TAP-binding protein {ECO:0000256|ARBA:ARBA00041647};
GN Name=TAPBP {ECO:0000313|Ensembl:ENSGGOP00000006450.2};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000006450.2, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000006450.2, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000006450.2, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000006450.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Involved in the association of MHC class I with transporter
CC associated with antigen processing (TAP) and in the assembly of MHC
CC class I with peptide (peptide loading).
CC {ECO:0000256|ARBA:ARBA00037757}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
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DR EMBL; CABD030044321; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030044322; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030044323; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030044324; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_004043866.1; XM_004043818.2.
DR AlphaFoldDB; G3QUP3; -.
DR STRING; 9593.ENSGGOP00000006450; -.
DR Ensembl; ENSGGOT00000006620.3; ENSGGOP00000006450.2; ENSGGOG00000006593.3.
DR GeneID; 101149497; -.
DR KEGG; ggo:101149497; -.
DR CTD; 6892; -.
DR eggNOG; ENOG502QR0A; Eukaryota.
DR GeneTree; ENSGT00940000159200; -.
DR HOGENOM; CLU_043155_0_0_1; -.
DR InParanoid; G3QUP3; -.
DR OMA; YMPPTLE; -.
DR OrthoDB; 4240386at2759; -.
DR TreeFam; TF334274; -.
DR Proteomes; UP000001519; Chromosome 6.
DR Bgee; ENSGGOG00000006593; Expressed in liver and 6 other cell types or tissues.
DR GO; GO:0000139; C:Golgi membrane; IEA:Ensembl.
DR GO; GO:0042824; C:MHC class I peptide loading complex; IBA:GO_Central.
DR GO; GO:0061779; C:Tapasin-ERp57 complex; IEA:Ensembl.
DR GO; GO:0023024; F:MHC class I protein complex binding; IBA:GO_Central.
DR GO; GO:0060090; F:molecular adaptor activity; IEA:Ensembl.
DR GO; GO:0044183; F:protein folding chaperone; IEA:Ensembl.
DR GO; GO:0062061; F:TAP complex binding; IBA:GO_Central.
DR GO; GO:0046978; F:TAP1 binding; IEA:Ensembl.
DR GO; GO:0046979; F:TAP2 binding; IEA:Ensembl.
DR GO; GO:0019885; P:antigen processing and presentation of endogenous peptide antigen via MHC class I; IEA:InterPro.
DR GO; GO:0002398; P:MHC class Ib protein complex assembly; IEA:Ensembl.
DR GO; GO:0002502; P:peptide antigen assembly with MHC class I protein complex; IBA:GO_Central.
DR GO; GO:0010468; P:regulation of gene expression; IEA:Ensembl.
DR GO; GO:0061635; P:regulation of protein complex stability; IEA:Ensembl.
DR Gene3D; 2.60.40.10; Immunoglobulins; 3.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003597; Ig_C1-set.
DR InterPro; IPR008056; Tapasin.
DR PANTHER; PTHR23411; TAPASIN; 1.
DR PANTHER; PTHR23411:SF22; TAPASIN; 1.
DR Pfam; PF07654; C1-set; 1.
DR PRINTS; PR01669; TAPASIN.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
PE 4: Predicted;
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..504
FT /note="Tapasin"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003451277"
FT TRANSMEM 416..437
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 292..399
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
SQ SEQUENCE 504 AA; 53961 MW; 4B01DC481E146F98 CRC64;
MKSLSLLLAV ALGLATAVSA GPAVIECWFV EDASGKGLAK RPGALLLRQG PGEPPPRPDL
DPELYLNVHD PAGALQAAFR RYPRGAPAPH CEMSRFVPLP ASAKWASGLT PAQNCPRALD
GAWLMVSISS PVLSLSSLLR PQPETQQEPV LITMATVVLT VLTHTPAPRV RLGQDALLDL
SFAYMPPTSE AASSLAPGPP PFGLEWRRQH LGKGHLLLAA TPGLNGRMPA AQEGAVAFAA
WDDDEPWGPW TGNGTFWLPR VQPFQEGTYL ATIHLPYLQG QVTLELAVYK PPKVSLMPAT
LARAAPGEVP PELLCLVSHF YPSGGLEVEW ELRGGPGGRS QKAEGQRWLS ALRHHSDGSV
SLSGHLQPPP VTTEQHGARY ACRIHHPSLP ASGRSAEVTL EVAGLSGPSL EDSVGLFLSA
FLLLGLFKAL GWAAVYLSTC KDSKKVQCST SLYLSLVTLS PHPISEPMEG GCWCGRQNLG
LESTLIWAKT WHYILTVGLF KRAT
//
