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Database: UniProt
Entry: G3QUZ2_GORGO
LinkDB: G3QUZ2_GORGO
Original site: G3QUZ2_GORGO 
ID   G3QUZ2_GORGO            Unreviewed;       369 AA.
AC   G3QUZ2;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 2.
DT   08-MAY-2019, entry version 46.
DE   RecName: Full=Ubiquinone biosynthesis O-methyltransferase, mitochondrial {ECO:0000256|HAMAP-Rule:MF_03190};
DE   AltName: Full=3-demethylubiquinol 3-O-methyltransferase {ECO:0000256|HAMAP-Rule:MF_03190};
DE            EC=2.1.1.64 {ECO:0000256|HAMAP-Rule:MF_03190};
DE   AltName: Full=Polyprenyldihydroxybenzoate methyltransferase {ECO:0000256|HAMAP-Rule:MF_03190};
DE            EC=2.1.1.114 {ECO:0000256|HAMAP-Rule:MF_03190};
GN   Name=COQ3 {ECO:0000256|HAMAP-Rule:MF_03190};
OS   Gorilla gorilla gorilla (Western lowland gorilla).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Gorilla.
OX   NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000006553, ECO:0000313|Proteomes:UP000001519};
RN   [1] {ECO:0000313|Ensembl:ENSGGOP00000006553, ECO:0000313|Proteomes:UP000001519}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Scally A.;
RT   "Insights into the evolution of the great apes provided by the gorilla
RT   genome.";
RL   Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSGGOP00000006553}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- FUNCTION: O-methyltransferase that catalyzes the 2 O-methylation
CC       steps in the ubiquinone biosynthetic pathway. {ECO:0000256|HAMAP-
CC       Rule:MF_03190}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=3,4-dihydroxy-5-all-trans-polyprenylbenzoate + S-
CC         adenosyl-L-methionine = 3-methoxy,4-hydroxy-5-all-trans-
CC         polyprenylbenzoate + H(+) + S-adenosyl-L-homocysteine;
CC         Xref=Rhea:RHEA:44452, Rhea:RHEA-COMP:10930, Rhea:RHEA-
CC         COMP:10931, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856,
CC         ChEBI:CHEBI:59789, ChEBI:CHEBI:64694, ChEBI:CHEBI:84443;
CC         EC=2.1.1.114; Evidence={ECO:0000256|HAMAP-Rule:MF_03190};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 3-demethylubiquinol + S-adenosyl-L-methionine = a
CC         ubiquinol + H(+) + S-adenosyl-L-homocysteine;
CC         Xref=Rhea:RHEA:44380, Rhea:RHEA-COMP:9566, Rhea:RHEA-COMP:10914,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:17976, ChEBI:CHEBI:57856,
CC         ChEBI:CHEBI:59789, ChEBI:CHEBI:84422; EC=2.1.1.64;
CC         Evidence={ECO:0000256|HAMAP-Rule:MF_03190};
CC   -!- PATHWAY: Cofactor biosynthesis; ubiquinone biosynthesis.
CC       {ECO:0000256|HAMAP-Rule:MF_03190}.
CC   -!- SUBUNIT: Component of a multi-subunit COQ enzyme complex, composed
CC       of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.
CC       {ECO:0000256|HAMAP-Rule:MF_03190}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000256|HAMAP-Rule:MF_03190}; Peripheral membrane protein
CC       {ECO:0000256|HAMAP-Rule:MF_03190}; Matrix side {ECO:0000256|HAMAP-
CC       Rule:MF_03190}.
CC   -!- SIMILARITY: Belongs to the class I-like SAM-binding
CC       methyltransferase superfamily. UbiG/COQ3 family.
CC       {ECO:0000256|HAMAP-Rule:MF_03190}.
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DR   EMBL; CABD030046839; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030046840; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_018884760.1; XM_019029215.1.
DR   STRING; 9593.ENSGGOP00000006553; -.
DR   Ensembl; ENSGGOT00000006725; ENSGGOP00000006553; ENSGGOG00000006696.
DR   GeneID; 101130141; -.
DR   KEGG; ggo:101130141; -.
DR   CTD; 51805; -.
DR   GeneTree; ENSGT00390000007284; -.
DR   InParanoid; G3QUZ2; -.
DR   KO; K00591; -.
DR   OrthoDB; 1542938at2759; -.
DR   TreeFam; TF314553; -.
DR   UniPathway; UPA00232; -.
DR   Proteomes; UP000001519; Chromosome 6.
DR   Bgee; ENSGGOG00000006696; Expressed in 7 organ(s), highest expression level in heart.
DR   GO; GO:0031314; C:extrinsic component of mitochondrial inner membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0008425; F:2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity; IEA:InterPro.
DR   GO; GO:1990886; F:3,4-dihydroxy-5-polyprenylbenzoic acid O-methyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0044596; F:3-demethylubiquinone-10 3-O-methyltransferase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0008689; F:3-demethylubiquinone-9 3-O-methyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0044595; F:decaprenyldihydroxybenzoate methyltransferase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0004395; F:hexaprenyldihydroxybenzoate methyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006071; P:glycerol metabolic process; IEA:Ensembl.
DR   GO; GO:0006744; P:ubiquinone biosynthetic process; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00472; UbiG; 1.
DR   InterPro; IPR029063; SAM-dependent_MTases.
DR   InterPro; IPR010233; UbiG_MeTrfase.
DR   SUPFAM; SSF53335; SSF53335; 1.
DR   TIGRFAMs; TIGR01983; UbiG; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001519};
KW   Membrane {ECO:0000256|HAMAP-Rule:MF_03190};
KW   Methyltransferase {ECO:0000256|HAMAP-Rule:MF_03190};
KW   Mitochondrion {ECO:0000256|HAMAP-Rule:MF_03190};
KW   Mitochondrion inner membrane {ECO:0000256|HAMAP-Rule:MF_03190};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW   S-adenosyl-L-methionine {ECO:0000256|HAMAP-Rule:MF_03190};
KW   Transferase {ECO:0000256|HAMAP-Rule:MF_03190};
KW   Ubiquinone biosynthesis {ECO:0000256|HAMAP-Rule:MF_03190}.
FT   BINDING     124    124       S-adenosyl-L-methionine.
FT                                {ECO:0000256|HAMAP-Rule:MF_03190}.
FT   BINDING     154    154       S-adenosyl-L-methionine; via carbonyl
FT                                oxygen. {ECO:0000256|HAMAP-Rule:
FT                                MF_03190}.
FT   BINDING     175    175       S-adenosyl-L-methionine.
FT                                {ECO:0000256|HAMAP-Rule:MF_03190}.
FT   BINDING     222    222       S-adenosyl-L-methionine; via carbonyl
FT                                oxygen. {ECO:0000256|HAMAP-Rule:
FT                                MF_03190}.
SQ   SEQUENCE   369 AA;  41330 MW;  C06980D918AD3528 CRC64;
     MWGGRKLGSS GGWFLRVLGP GGWNTKAARR LISSAVYVKN QLSWTLQIKP GIFNEYRTIW
     FKSYRMIFSC LNRIKSFRYP WARLYSTSQT TVDSGEVKTF LALAHKWWDE QGVYAPLHSM
     NDLRVPFIRD NLLKTIPNHQ PGKPLLGMKI LDVGCGGGLL TEPLGRLGAS VIGIDPVDEN
     VKTAQCHKSF DPVLDKRIEY RVCSLEEIVE ETAETFDAVV ASEVVEHVID LETFLQCCCQ
     VLKPGGSLFI TTINKTQLSY ALGIVFSEQI AGIVPKGTHT WEKFVSPETL ESILESNGLS
     VQTVVGMLYN PFSGYWHWSE NTSLNYAAHA VKSRVQEHPT SAEFVLKGET EELQANTCTN
     PAVHEELKK
//
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