ID G3QVC8_GORGO Unreviewed; 583 AA.
AC G3QVC8;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 58.
DE SubName: Full=Leucine rich repeats and calponin homology domain containing 1 {ECO:0000313|Ensembl:ENSGGOP00000006692.3};
GN Name=LRCH1 {ECO:0000313|Ensembl:ENSGGOP00000006692.3};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000006692.3, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000006692.3, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000006692.3, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000006692.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; CABD030088905; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030088906; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030088907; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030088908; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030088909; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030088910; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G3QVC8; -.
DR Ensembl; ENSGGOT00000006865.3; ENSGGOP00000006692.3; ENSGGOG00000006833.3.
DR eggNOG; KOG0532; Eukaryota.
DR GeneTree; ENSGT00940000159528; -.
DR HOGENOM; CLU_074728_0_0_1; -.
DR TreeFam; TF318428; -.
DR Proteomes; UP000001519; Chromosome 13.
DR Bgee; ENSGGOG00000006833; Expressed in cerebellum and 6 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd21270; CH_LRCH1; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR PANTHER; PTHR48051; -; 1.
DR PANTHER; PTHR48051:SF4; LEUCINE RICH REPEATS AND CALPONIN HOMOLOGY DOMAIN CONTAINING 1; 1.
DR Pfam; PF00307; CH; 1.
DR Pfam; PF13855; LRR_8; 2.
DR SMART; SM00033; CH; 1.
DR SMART; SM00364; LRR_BAC; 4.
DR SMART; SM00369; LRR_TYP; 4.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR PROSITE; PS50021; CH; 1.
DR PROSITE; PS51450; LRR; 2.
PE 4: Predicted;
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 558..576
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 431..547
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT REGION 25..57
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 373..403
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 373..401
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 583 AA; 64603 MW; 57C27AED74BC9FB9 CRC64;
MATPGSEPQP FVPALSVATL HPLHHPHHHH HHQQHHGGTG APGGASGGGG GSGGFNLPLN
RGLERALEEA ANSGGLNLSA RKLKEFPRTA VPGHDLSDTV QADLSKNRLV EVPMELCHFV
SLEILNLYHN CIRVIPEAIV NLQMLTYLNL SRNQLSTLPA CLCGLPLKVL IASNNKLGSL
PEEIGQLKQL MELDVSCNEI TALPQQIGQL KSLRELNVRR NYLKVLPQGE FHQEFQPEAS
LLGDSTNSGE ERDQFTDRAD GLHSEFMNYK ARAEDCEELL RIEEDVHWQT EGIISSSKDQ
DMDIAMIEQL REAVDLLQDP NGLSTDITER SVLNLYPMGS AEALELQDSA LNGQIQLETS
LVCEVQSDLT LQSNGSQYSP NEVRENSPAV SPTTNSTAPF GLKPRSVFLR PQRNLESIDP
QFTIRRKMEQ MREEKELVEQ LRESIEMRLK VSLHEDLGAA LMDGVVLCHL VNHIRPRSVA
SIHVPSPAVP KLSMAKCRRN VENFLEACRK LGVPEADLCS PCDILQLDFR HIRKTVDTLL
ALGEKAPPPT SALRSRDLIG FCLVHILFIV LVYITYHWNA LSA
//
