ID G3QVP4_GORGO Unreviewed; 2485 AA.
AC G3QVP4;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 64.
DE SubName: Full=Neuron navigator 2 {ECO:0000313|Ensembl:ENSGGOP00000006822.3};
GN Name=NAV2 {ECO:0000313|Ensembl:ENSGGOP00000006822.3};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000006822.3, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000006822.3, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000006822.3, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000006822.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the Nav/unc-53 family.
CC {ECO:0000256|ARBA:ARBA00006255}.
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DR EMBL; CABD030077759; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030077760; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030077761; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030077762; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030077763; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030077764; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030077765; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030077766; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030077767; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 9593.ENSGGOP00000006822; -.
DR Ensembl; ENSGGOT00000007001.3; ENSGGOP00000006822.3; ENSGGOG00000006949.3.
DR eggNOG; ENOG502QPT3; Eukaryota.
DR GeneTree; ENSGT00940000155663; -.
DR HOGENOM; CLU_001002_1_1_1; -.
DR InParanoid; G3QVP4; -.
DR OMA; NSVHFSF; -.
DR TreeFam; TF329881; -.
DR Proteomes; UP000001519; Chromosome 11.
DR Bgee; ENSGGOG00000006949; Expressed in cerebellum and 6 other cell types or tissues.
DR GO; GO:0005614; C:interstitial matrix; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0043138; F:3'-5' DNA helicase activity; IEA:Ensembl.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0008201; F:heparin binding; IEA:Ensembl.
DR GO; GO:0021563; P:glossopharyngeal nerve development; IEA:Ensembl.
DR GO; GO:0007626; P:locomotory behavior; IEA:Ensembl.
DR GO; GO:0022008; P:neurogenesis; IEA:InterPro.
DR GO; GO:0021554; P:optic nerve development; IEA:Ensembl.
DR GO; GO:0003025; P:regulation of systemic arterial blood pressure by baroreceptor feedback; IEA:Ensembl.
DR GO; GO:0007608; P:sensory perception of smell; IEA:Ensembl.
DR GO; GO:0007605; P:sensory perception of sound; IEA:Ensembl.
DR GO; GO:0021564; P:vagus nerve development; IEA:Ensembl.
DR CDD; cd21285; CH_NAV2; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR039041; Nav/unc-53.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR12784:SF6; NEURON NAVIGATOR 2; 1.
DR PANTHER; PTHR12784; STEERIN; 1.
DR Pfam; PF00307; CH; 1.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00033; CH; 1.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS50021; CH; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000001519}.
FT DOMAIN 85..192
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT REGION 194..675
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 706..728
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 804..824
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 939..1151
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1177..1200
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1213..1283
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1295..1338
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1355..1412
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1440..1460
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1473..1560
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1787..1884
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1948..1982
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2420..2485
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1683..1766
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 214..234
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 241..272
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 295..319
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 334..394
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 445..467
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 503..548
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 616..675
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 706..727
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 804..818
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 939..989
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 990..1047
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1048..1064
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1125..1148
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1213..1246
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1263..1283
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1295..1309
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1473..1490
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1496..1512
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1541..1560
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1787..1815
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1816..1831
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1855..1884
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1955..1982
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2452..2467
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2485 AA; 267801 MW; 1B4E3D4B5E7DB66F CRC64;
MPAILVASKM KSGLPKPVHS AAPILHVPPA RAGPQPCYLK LGSKVEVSKT TYPSQIPLKS
QVLQGLQEPA GEGLPLRKSG SVENGFDTQI YTDWANHYLA KSGHKRLIKD LQQDVTDGVL
LAQIIQVVAN EKIEDINGCP KNRSQMIENI DACLNFLAAK GINIQGLSAE EIRNGNLKAI
LGLFFSLSRY KQQQQQPQKQ HLSSPLPPAV SQVAGAPSQC QAGTPQQQVP VTPQAPCQPH
QPAPHQQSKA QAEMQSSASS KDSSQSKIIR FTLGQKKISR LPGPTARVSA AGSEAKTRGG
STTANNRRSQ SFNNYDKSKP VTSPPPPPSS HEKEPLASSA SSHPGMSDNA PASLESGSSS
TPTNCSTSSA IPQPGTATKP WRSKSLSVKH SATVSMLSVK PPGPEAPRPT PEAMKPAPNN
QKSMLEKLKL FNSKGGSKAG EGPGSRDTSC ERLETLPSFE ESEELEAASR MLTTVGPASS
SPKIALKGIA QRTFSRALTN KKSSLKGNEK EKEKQQREKD KEKSKDLAKR ASVTERLDLK
EEPKEDPSGA AVPEMPKKSS KIASFIPKGG KLNSAKKEPM APSHSGIPKP GMKSMPGKSP
SAPAPSKEGE RSRSGKLSSG LPQQKPQLDG RHSSSSSSLA SSEGKGPGGT TLNHSISSQT
VSGSVGTTQT TGSNTVSVQL PQPQQQYNHP NTATVAPFLY RSQTDTEGNV TAESSSTGVS
MEPSHFTKTG QPALEELTGE DPEARRLRTV KNIADLRQNL EETMSSLRGT QVTHSTLETT
FDTNVTTEMS GRSILSLTGR PTPLSWRLGQ SSPRLQAGDA PSMGNGYPPR ANASRFINTE
SGRYVYSAPL RRQLASRGSS VCHVDVSDKA GDEMDLEGIS MDAPGYMSDG DVLSKNIRTD
DITSGYMTDG GLGLYTRRLN RLPDGMAVVR ETLQRNTSLG LGDADSWDDS SSVSSGISDT
IDNLSTDDIN TSSSISSYAN TPASSRKNLD VQTDAEKHSQ VERNSLWSGD DVKKSDGGSD
SGIKMEPGSK WRRNPSDVSD ESDKSTSGKK NPVISQTGSW RRGMTAQVGI TMPRTKPSAP
AGALKTPGTG KTDDAKVSEK GRLSPKASQV KRSPSDAGRS SGDESKKPLP SSSRTPTANA
NSFGFKKQSG SAAGLAMITA SGVTVTSRSA TLGKIPKSSA LVSRSAGRKS SMDGAQNQDD
GYLALSSRTN LQYRSLPRPS KSNSRNGAGN RSSTSSIDSN ISSKSAGLPV PKLREPSKTA
LGSSLPGLVN QTDKEKGISS DNESVASCNS VKVNPAAQPV SSPAQTSLQP GAKYPDVASP
TLRRLFGGKP TKQVPIATAE NMKNSVVISN PHATMTQQGN LDSPSGSGVL SSGSSSPLYS
KNVDLNQSPL ASSPSSAHSA PSNSLTWGTN ASSSSAVSKD GLGFQSVSSL HTSCESIDIS
LSSGGVPSHN SSTGLIASSK DDSLTPFVRT NSVKTTLSES PLSSPAASPK FCRSTLPRKQ
DSDPHLDRNT LPKKGLRYTP TSQLRTQEDA KEWLRSHSAG GLQDTAANSP FSSGSSVTSP
SGTRFNFSQL ASPTTVTQMS LSNPTMLRTH SLSNADGQYD PYTDSRFRNS SMSLDEKSRT
MSRSGSFRDG FSWEKSSVDN FVSCLHSSLH FSLPLFHHPR YELVHGSSLS LVSSTSSIYS
TPEEKCQSEI RKLRRELDAS QEKVSALTTQ LTANAHLVAA FEQSLGNMTI RLQSLTMTAE
QKDSELNELR KTIELLKKQN AAAQAAINGV INTPELNCKG NGTAQSADLR IRRQHSSDSV
SSINSATSHS SVGSNIESDS KKKKRKNWVN ELRSSFKQAF GKKKSPKSAS SHSDIEEMTD
SSLPSSPKLP HNGSTGSTPL LRNSHSNSLI SECMDSEAET VMQLRNELRD KEMKLTDIRL
EALSSAHQLD QLREAMNRMQ SEIEKLKAEN DRLKSESQGS GCSRAPSQVS ISASPRQSMG
LSQHSLNLTE STSLDMLLDD TGECSARKEG GRHVKIVVSF QEEMKWKEDS RPHLFLIGCI
GVSGKTKWDV LDGVVRRLFK EYIIHVDPVS QLGLNSDSVL GYSIGEIKRS NTSETPELLP
CGYLVGENTT ISVTVKGLAE NSLDSLVFES LIPKPILQRY VSLLIEHRRI ILSGPSGTGK
TYLANRLSEY IVLREGRELT DGVIATFNVD HKSSKELRQY LSNLADQCNS ENNAVDMPLV
IILDNLHHVS SLGEIFNGLL NCKYHKCPYI IGTMNQATSS TPNLQLHHNF RWVLCANHTE
PVKGFLGRFL RRKLMETEIS GRMRNVELVK IIDWIPKVWH HLNRFLEAHS SSDVTIGPRL
FLSCPIDVDG SRVWFTDLWN YSIIPYLLEA VREGLQLYGR RAPWEDPAKW VMDTYPWAAS
PQQHEWPPLL QLRPEDVGFD GYSMPREGST SKQMPPSDAE GDPLMNMLMR LQEAANYSSP
QSYDSDSNSN SHHDDILDSS LESTL
//
