ID G3QW18_GORGO Unreviewed; 130 AA.
AC G3QW18;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 70.
DE SubName: Full=Glycoprotein hormone subunit beta 5 {ECO:0000313|Ensembl:ENSGGOP00000006959.1};
GN Name=GPHB5 {ECO:0000313|Ensembl:ENSGGOP00000006959.1};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000006959.1, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000006959.1, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000006959.1, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000006959.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the glycoprotein hormones subunit beta family.
CC {ECO:0000256|ARBA:ARBA00006552}.
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DR EMBL; CABD030092731; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_004055324.1; XM_004055276.2.
DR AlphaFoldDB; G3QW18; -.
DR STRING; 9593.ENSGGOP00000006959; -.
DR Ensembl; ENSGGOT00000007145.2; ENSGGOP00000006959.1; ENSGGOG00000007121.3.
DR GeneID; 101138178; -.
DR KEGG; ggo:101138178; -.
DR CTD; 122876; -.
DR eggNOG; ENOG502RZ3V; Eukaryota.
DR GeneTree; ENSGT00730000111179; -.
DR HOGENOM; CLU_126319_2_1_1; -.
DR InParanoid; G3QW18; -.
DR OMA; MAVRCDC; -.
DR OrthoDB; 2945053at2759; -.
DR TreeFam; TF332940; -.
DR Proteomes; UP000001519; Chromosome 14.
DR Bgee; ENSGGOG00000007121; Expressed in regional part of brain and 1 other cell type or tissue.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005179; F:hormone activity; IEA:InterPro.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:Ensembl.
DR GO; GO:0031531; F:thyrotropin-releasing hormone receptor binding; IEA:Ensembl.
DR GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0002155; P:regulation of thyroid hormone mediated signaling pathway; IBA:GO_Central.
DR CDD; cd00069; GHB_like; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR006208; Glyco_hormone_CN.
DR InterPro; IPR001545; Gonadotropin_bsu.
DR PANTHER; PTHR11515; GLYCOPROTEIN HORMONE BETA CHAIN; 1.
DR PANTHER; PTHR11515:SF14; GLYCOPROTEIN HORMONE BETA-5; 1.
DR Pfam; PF00007; Cys_knot; 1.
DR SMART; SM00068; GHB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..130
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003451738"
FT DOMAIN 35..128
FT /note="Glycoprotein hormone subunit beta"
FT /evidence="ECO:0000259|Pfam:PF00007"
SQ SEQUENCE 130 AA; 14217 MW; 282B1200AA6725B9 CRC64;
MKLAFLFLGP MALLLLAGYG CVLGASSGNL RTFVGCAVRE FTFLAKKPGC RGLRITTDAC
WGRCETWEKP ILEPPYIEAH HRVCTYNETK QVTVKLPICA PGVDPFYTYP VAVRCDCGAC
STATTECETI
//
