ID G3QWL2_GORGO Unreviewed; 587 AA.
AC G3QWL2;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 70.
DE SubName: Full=Leucine rich repeat containing 15 {ECO:0000313|Ensembl:ENSGGOP00000007172.2};
GN Name=LRRC15 {ECO:0000313|Ensembl:ENSGGOP00000007172.2};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000007172.2, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000007172.2, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000007172.2, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000007172.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; CABD030026343; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_004038283.1; XM_004038235.2.
DR AlphaFoldDB; G3QWL2; -.
DR STRING; 9593.ENSGGOP00000007172; -.
DR Ensembl; ENSGGOT00000007362.3; ENSGGOP00000007172.2; ENSGGOG00000007329.3.
DR GeneID; 101140108; -.
DR CTD; 131578; -.
DR eggNOG; KOG0619; Eukaryota.
DR GeneTree; ENSGT00940000161771; -.
DR HOGENOM; CLU_000288_18_6_1; -.
DR InParanoid; G3QWL2; -.
DR OMA; HNNSWRC; -.
DR OrthoDB; 5357459at2759; -.
DR TreeFam; TF351124; -.
DR Proteomes; UP000001519; Chromosome 3.
DR GO; GO:0016324; C:apical plasma membrane; IEA:Ensembl.
DR GO; GO:0062023; C:collagen-containing extracellular matrix; IEA:Ensembl.
DR GO; GO:0005518; F:collagen binding; IEA:Ensembl.
DR GO; GO:0001968; F:fibronectin binding; IEA:Ensembl.
DR GO; GO:0043236; F:laminin binding; IEA:Ensembl.
DR GO; GO:0140311; F:protein sequestering activity; IEA:Ensembl.
DR GO; GO:0007596; P:blood coagulation; IBA:GO_Central.
DR GO; GO:1903077; P:negative regulation of protein localization to plasma membrane; IEA:Ensembl.
DR GO; GO:0046597; P:negative regulation of viral entry into host cell; IEA:Ensembl.
DR GO; GO:0030335; P:positive regulation of cell migration; IEA:Ensembl.
DR GO; GO:0046813; P:receptor-mediated virion attachment to host cell; IEA:Ensembl.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 4.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR PANTHER; PTHR24369; ANTIGEN BSP, PUTATIVE-RELATED; 1.
DR PANTHER; PTHR24369:SF210; CHAOPTIN-RELATED; 1.
DR Pfam; PF00560; LRR_1; 1.
DR Pfam; PF13855; LRR_8; 4.
DR SMART; SM00365; LRR_SD22; 6.
DR SMART; SM00369; LRR_TYP; 14.
DR SMART; SM00082; LRRCT; 1.
DR SUPFAM; SSF52058; L domain-like; 2.
DR PROSITE; PS51450; LRR; 4.
PE 4: Predicted;
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..27
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 28..587
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003451662"
FT TRANSMEM 545..570
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 429..481
FT /note="LRRCT"
FT /evidence="ECO:0000259|SMART:SM00082"
FT REGION 495..514
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 499..514
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 587 AA; 65011 MW; 2A577408396186B2 CRC64;
MPLDKAMPLK HYLLLLVGCQ AWGAGLAYHG CPSECTCSRA SQVECTGARI VAVPTPLPWN
AMSLQILNTH ITELNESPFL NISALIALRI EKNELSRIMP GAFRNLGSLR YLSLANNKLQ
VLPIGLFQGL DSLESLLLSS NQLVQIQPAH FSQCSNLKEL QLHGNHLEYI PDGAFDHLAG
LTKLNLGKNS LTHISPRVFQ HLGNLQVLRL YENRLADIPM GTFDGLVNLQ ELALQQNQIG
LLSPGLFHNN HNLQRLYLSN NHISQLPPSI FMQLPQLNRL TLFGNSLKEL SPGIFGPMPN
LRELWLYDNH ISSLPDNVFS NLRQLQVLIL SRNQISFISP GAFNGLTELR ELSLHTNALQ
DLDGNVFRML ANLQNISLQN NRLRQLPGNI FANVNGLMTI QLQNNQLENL PLGIFDHLGK
LCELRLYDNP WRCDSDILPL RNWLLLNQPR LGTDTVPVCF SPASVRGQSL IIINVNVAVP
SVHVPEVPSY PETPWYPDTP SYPDTTSVSS TTELTSPVED YTDLTTIQVT DDRSVWGMTQ
AQSGLAIAAI VIGIVALACS LAACIGCCCC KKRSQAVLMQ MKAPNEC
//
