ID G3QZX8_GORGO Unreviewed; 673 AA.
AC G3QZX8;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=Leucine zipper tumor suppressor family member 3 {ECO:0000313|Ensembl:ENSGGOP00000008451.2};
GN Name=LZTS3 {ECO:0000313|Ensembl:ENSGGOP00000008451.2};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000008451.2, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000008451.2, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000008451.2, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000008451.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CABD030115306; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_004061773.1; XM_004061725.2.
DR RefSeq; XP_018873038.1; XM_019017493.1.
DR RefSeq; XP_018873039.1; XM_019017494.1.
DR AlphaFoldDB; G3QZX8; -.
DR SMR; G3QZX8; -.
DR STRING; 9593.ENSGGOP00000008451; -.
DR Ensembl; ENSGGOT00000008683.3; ENSGGOP00000008451.2; ENSGGOG00000008647.3.
DR GeneID; 101148905; -.
DR KEGG; ggo:101148905; -.
DR CTD; 9762; -.
DR eggNOG; ENOG502QWFS; Eukaryota.
DR GeneTree; ENSGT00940000154078; -.
DR HOGENOM; CLU_026379_1_0_1; -.
DR InParanoid; G3QZX8; -.
DR OMA; HMQQDIQ; -.
DR OrthoDB; 5394101at2759; -.
DR TreeFam; TF331420; -.
DR Proteomes; UP000001519; Chromosome 20.
DR Bgee; ENSGGOG00000008647; Expressed in cerebellum and 5 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0043197; C:dendritic spine; IBA:GO_Central.
DR GO; GO:0061001; P:regulation of dendritic spine morphogenesis; IBA:GO_Central.
DR InterPro; IPR045329; LZTS.
DR PANTHER; PTHR19354; ZIPPER PUTATIVE TUMOR SUPPRESSOR 2 HOMOLOG-LIKE PROTEIN-RELATED; 1.
DR PANTHER; PTHR19354:SF6; ZIPPER PUTATIVE TUMOR SUPPRESSOR 3-RELATED; 1.
DR Pfam; PF06818; Fez1; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Reference proteome {ECO:0000313|Proteomes:UP000001519}.
FT REGION 1..157
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 172..239
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 251..317
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 635..673
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 321..427
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 58..72
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 112..130
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 175..189
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 207..239
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 251..294
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 657..673
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 673 AA; 71791 MW; 3E548EC03A01F770 CRC64;
MAKLETLPVR ADPGRDPLLA FAPRPSELGP PDPRLAMGSV GSGVAHAQEF AMKSVGTRTG
GGGSQGSFPG PRGSGSGASR ERPGRYPSED KGLANSLYLN GELRGSDHTD VCGNVVGSSG
GSSSSGGSDK APPQYREPSH PPKLLATSGK LDQCSEPLVR PSAFKPVVPK NFHSMQNLCP
PQTNGTPEGR QGPGGLKGGL DKSRTMTPAG GSGSGLSDSG RNSLTSLPTY SSSYSQHLAP
LSASTSHINR IGTASYGSGS GGSSGGGSGY QDLGTSDSGR ASSKSGSSSS MGRPGHLGSG
EGGGGGLPFA ACSPPSPSAL IQELEERLWE KEQEVAALRR SLEQSEAAVA QVLEERQKAW
ERELAELRQG CSGKLQQVAR RAQRAQQGLQ LQVLRLQQDK KQLQEEAARL MRQREELEDK
VAACQKEQAD FLPRIEETKW EVCQKAGEIS LLKQQLKDSQ ADVSQKLSEI VGLRSQLREG
RASLREKEEQ LLSLRDSFSS KQASLELGEG ELPAACLKPA LTPVDPAEPQ DALATCESDE
AKMRRQAGVA AAASLVSVDG EAEAGGESGT RALRREVGRL QAELAAERRA RERQGASFAE
ERRVWLEEKE KVIEYQKQLQ LSYVEMYQRN QQLERRLRER GAAGGASTPT PQHGEEKKAW
TPSRLERIES TEI
//
