ID G3R098_GORGO Unreviewed; 435 AA.
AC G3R098;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 64.
DE SubName: Full=Serpin family A member 9 {ECO:0000313|Ensembl:ENSGGOP00000008579.3};
GN Name=SERPINA9 {ECO:0000313|Ensembl:ENSGGOP00000008579.3};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000008579.3, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000008579.3, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000008579.3, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000008579.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the serpin family.
CC {ECO:0000256|RuleBase:RU000411}.
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DR EMBL; CABD030093895; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030093896; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_004055681.2; XM_004055633.2.
DR AlphaFoldDB; G3R098; -.
DR STRING; 9593.ENSGGOP00000008579; -.
DR Ensembl; ENSGGOT00000008814.3; ENSGGOP00000008579.3; ENSGGOG00000008775.3.
DR GeneID; 101149586; -.
DR KEGG; ggo:101149586; -.
DR CTD; 327657; -.
DR eggNOG; KOG2392; Eukaryota.
DR GeneTree; ENSGT00940000162880; -.
DR InParanoid; G3R098; -.
DR OMA; FNPADTH; -.
DR OrthoDB; 3218836at2759; -.
DR TreeFam; TF343201; -.
DR Proteomes; UP000001519; Chromosome 14.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IBA:GO_Central.
DR CDD; cd19556; serpinA9_centerin; 1.
DR Gene3D; 2.30.39.10; Alpha-1-antitrypsin, domain 1; 1.
DR Gene3D; 3.30.497.10; Antithrombin, subunit I, domain 2; 1.
DR Gene3D; 2.10.310.10; Serpins superfamily; 1.
DR InterPro; IPR023795; Serpin_CS.
DR InterPro; IPR023796; Serpin_dom.
DR InterPro; IPR000215; Serpin_fam.
DR InterPro; IPR036186; Serpin_sf.
DR InterPro; IPR042178; Serpin_sf_1.
DR InterPro; IPR042185; Serpin_sf_2.
DR PANTHER; PTHR11461; SERINE PROTEASE INHIBITOR, SERPIN; 1.
DR PANTHER; PTHR11461:SF40; SERPIN A9; 1.
DR Pfam; PF00079; Serpin; 1.
DR PRINTS; PR00780; LEUSERPINII.
DR SMART; SM00093; SERPIN; 1.
DR SUPFAM; SSF56574; Serpins; 1.
DR PROSITE; PS00284; SERPIN; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 21..37
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 71..432
FT /note="Serpin"
FT /evidence="ECO:0000259|SMART:SM00093"
SQ SEQUENCE 435 AA; 48381 MW; BA375A143C77A324 CRC64;
MQGQGKRRGT CKDVFCSKMA SSLYGVLFAV GLCAPMYCAS PANAPSGYPH PSSTKSTPAS
QVYSLNTDFA FRLYRRLVLE TPSQNIFFSP VSVSTSLAML SLGAHSVTKT QILQGLGFNL
THTPESAIHQ GFQHLVHSLT VPSKDLTLKM GSALFVKKEL QLQANFLGNV KRLYEAEVFS
TDFSNPSIAQ ARINSHVKKK TQGKVVDIIQ DLDLLTAMVL VNHIFFKAKW EKPFHPAYTR
KNFPFLVGKQ VTVPVPMMHQ KEQFAFGVDT ELNCFVLQMD YKGDAVAFFV LPSKGKMRQL
EQALSARTLR KWSHSLQKRW IEVFIPRFSI SASYNLETIL PKMGIQNAFD ENADFSGITK
RDSLQVSKAT HKAVLDVSEE GTEAAAATAT KFIVRSKDGP SYFTVSFNRT FLMMITNKAT
DSILFLGKVE NPTKS
//
