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Database: UniProt
Entry: G3R0B9_GORGO
LinkDB: G3R0B9_GORGO
Original site: G3R0B9_GORGO 
ID   G3R0B9_GORGO            Unreviewed;       840 AA.
AC   G3R0B9;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 2.
DT   20-JUN-2018, entry version 38.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   Name=ATP6V0A4 {ECO:0000313|Ensembl:ENSGGOP00000008602};
OS   Gorilla gorilla gorilla (Western lowland gorilla).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Gorilla.
OX   NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000008602, ECO:0000313|Proteomes:UP000001519};
RN   [1] {ECO:0000313|Ensembl:ENSGGOP00000008602, ECO:0000313|Proteomes:UP000001519}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Scally A.;
RT   "Insights into the evolution of the great apes provided by the gorilla
RT   genome.";
RL   Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSGGOP00000008602}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
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DR   EMBL; CABD030055383; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030055384; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030055385; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_018887120.1; XM_019031575.1.
DR   RefSeq; XP_018887121.1; XM_019031576.1.
DR   STRING; 9593.ENSGGOP00000008602; -.
DR   Ensembl; ENSGGOT00000008837; ENSGGOP00000008602; ENSGGOG00000008794.
DR   GeneID; 101140521; -.
DR   KEGG; ggo:101140521; -.
DR   CTD; 50617; -.
DR   GeneTree; ENSGT00390000004941; -.
DR   InParanoid; G3R0B9; -.
DR   KO; K02154; -.
DR   OMA; FILRANH; -.
DR   OrthoDB; EOG091G01BI; -.
DR   TreeFam; TF300346; -.
DR   Proteomes; UP000001519; Chromosome 7.
DR   Bgee; ENSGGOG00000008794; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:proton transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001519};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    403    427       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    447    466       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    545    566       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    572    596       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    642    661       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    771    796       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   COILED       93    127       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   840 AA;  96300 MW;  379DDD315462B6D8 CRC64;
     MASVFRSEEM CLSQLFLQVE AAYCCVAELG ELGLVQFKDL NMNVNSFQRK FVNEVRRCES
     LERILRFLED EMQNEIVVQL LEKSPLTPLP REMITLETVL EKLEGELQEA NQNQQALKQS
     FLELTELKYL LKKTQDFFET ETSLADDFFT EDTSGLLELK AVPAYMTGKL GFIAGVINRE
     RMASFERLLW RICRGNVYLK FSEMDAPLED PVTKEEIQKN IFIIFYQGEQ LRQKIKKICD
     GFRATVYPCP EPAVERREML ESVNVRLEDL ITVITQTESH RQRLLQEAAA NWHSWLIKVQ
     KMKAVYHILN MCNIDVTQQC VIAEIWFPVA DATRIKRALE QGMELSGSSM APIMTTVQSK
     TAPPTFNRTN KFTAGFQNIV DAYGVGSYRE INPAPYTIIT FPFLFAVMFG DCGHGTVMLL
     AALWMILNER RLLSQKTDNE IWNTFFHGRY LILLMGIFSI YTGLIYNDCF SKSLNIFGSS
     WSVQPMFRNG TWNTHVMEAN LYLQLDPAIP GVYFGNPYPF GIDPIWNLAS NKLTFLNSYK
     MKMSVILGIV QMVFGVILSL FNHIYFRRTL NIILQFIPEM IFILCLFGYL VFMIIFKWCC
     FDVHVSQHAP SILIHFINMF LFNYSDSSNA PLYKHQQEVQ SFFVVMALIS VPWMLLIKPF
     ILRASHRKSQ LQASRIQEDA TENIEGDSSS PSSRSGQRTS ADTHGALDDH GEEFNFGDVF
     VHQAIHTIEY CLGCISNTAS YLRLWALSLA HAQLSEVLWT MVMNSGLQTR GWGGIVGVFI
     IFAVFAVLTV AILLIMEGLS AFLHALRLHW VEFQNKFYVG DGYKFSPFSF KHILDGTAEE
//
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