ID G3R0P5_GORGO Unreviewed; 1077 AA.
AC G3R0P5;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=Dishevelled associated activator of morphogenesis 2 {ECO:0000313|Ensembl:ENSGGOP00000008737.3};
GN Name=DAAM2 {ECO:0000313|Ensembl:ENSGGOP00000008737.3};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000008737.3, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000008737.3, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000008737.3, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000008737.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; CABD030044614; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_018884998.1; XM_019029453.1.
DR RefSeq; XP_018884999.1; XM_019029454.1.
DR RefSeq; XP_018885000.1; XM_019029455.1.
DR AlphaFoldDB; G3R0P5; -.
DR STRING; 9593.ENSGGOP00000008737; -.
DR Ensembl; ENSGGOT00000008975.3; ENSGGOP00000008737.3; ENSGGOG00000008927.3.
DR GeneID; 101148305; -.
DR CTD; 23500; -.
DR GeneTree; ENSGT00940000157801; -.
DR InParanoid; G3R0P5; -.
DR OMA; PCFGMGL; -.
DR OrthoDB; 5485896at2759; -.
DR Proteomes; UP000001519; Chromosome 6.
DR Bgee; ENSGGOG00000008927; Expressed in frontal cortex and 6 other cell types or tissues.
DR GO; GO:0003779; F:actin binding; IEA:InterPro.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0030036; P:actin cytoskeleton organization; IEA:InterPro.
DR GO; GO:0007368; P:determination of left/right symmetry; IEA:Ensembl.
DR GO; GO:0021516; P:dorsal spinal cord development; IEA:Ensembl.
DR GO; GO:0048715; P:negative regulation of oligodendrocyte differentiation; IBA:GO_Central.
DR GO; GO:0090521; P:podocyte cell migration; IEA:Ensembl.
DR GO; GO:0090263; P:positive regulation of canonical Wnt signaling pathway; IBA:GO_Central.
DR GO; GO:0030335; P:positive regulation of cell migration; IEA:Ensembl.
DR GO; GO:0030833; P:regulation of actin filament polymerization; IEA:Ensembl.
DR GO; GO:0051489; P:regulation of filopodium assembly; IEA:Ensembl.
DR GO; GO:2000050; P:regulation of non-canonical Wnt signaling pathway; IBA:GO_Central.
DR Gene3D; 1.20.58.2220; Formin, FH2 domain; 1.
DR Gene3D; 1.10.238.150; Formin, FH3 diaphanous domain; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR014767; DAD_dom.
DR InterPro; IPR015425; FH2_Formin.
DR InterPro; IPR042201; FH2_Formin_sf.
DR InterPro; IPR010472; FH3_dom.
DR InterPro; IPR014768; GBD/FH3_dom.
DR InterPro; IPR010473; GTPase-bd.
DR PANTHER; PTHR45725:SF7; DISHEVELED-ASSOCIATED ACTIVATOR OF MORPHOGENESIS 2; 1.
DR PANTHER; PTHR45725; FORMIN HOMOLOGY 2 FAMILY MEMBER; 1.
DR Pfam; PF06367; Drf_FH3; 1.
DR Pfam; PF06371; Drf_GBD; 1.
DR Pfam; PF02181; FH2; 1.
DR SMART; SM01139; Drf_FH3; 1.
DR SMART; SM01140; Drf_GBD; 1.
DR SMART; SM00498; FH2; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF101447; Formin homology 2 domain (FH2 domain); 1.
DR PROSITE; PS51231; DAD; 1.
DR PROSITE; PS51444; FH2; 1.
DR PROSITE; PS51232; GBD_FH3; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000001519}.
FT DOMAIN 40..416
FT /note="GBD/FH3"
FT /evidence="ECO:0000259|PROSITE:PS51232"
FT DOMAIN 595..1003
FT /note="FH2"
FT /evidence="ECO:0000259|PROSITE:PS51444"
FT DOMAIN 1025..1057
FT /note="DAD"
FT /evidence="ECO:0000259|PROSITE:PS51231"
FT REGION 514..586
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 434..510
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 697..724
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 933..1010
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 538..580
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1077 AA; 124515 MW; 4AEAF36888543228 CRC64;
MAPRKRSRHG LGFLCCFGGS DIPEINLRDN HPLQFMEFSS PIPNAEELNI RFAELVDELD
LTDKNREAMF ALPPEKKWQI YCSKKKEQED PNKLATSWPD YYIDRINSMA AMQSLYAFDE
EETEMRNQVV EDLKTALRTQ PMRFVTRFIE LEGLTCLLNF LRSMDHATCE SRIHTSLIGC
IKALMNNSQG RAHVLAQPEA ISTIAQSLRT ENSKTKVAVL EILGAVCLVP GGHKKVLQAM
LHYQVYAAER TRFQTLLNEL DRSLGRYRDE VNLKTAIMSF INAVLNAGAG EDNLEFRLHL
RYEFLMLGIQ PVIDKLRQHE NAILDKHLDF FEMVRNEDDL ELARRFDMVH IDTKSASQMF
ELIHKKLKYT EAYPCLLSVL HHCLQMPYKR NGGYFQQWQL LDRILQQIVL QDERGVDPDL
APLENFNVKN IVNMLINENE VKQWRDQAEK FRKEHMELVS RLERKERECE TKTLEKEEMM
RTLNKMKDKL ARESQELRQA RGQVAELVAQ LSELSTGPVS SPPPPGGPLT LSSSMTTNDL
PPPPPPLPFA CCPPPPPPPL PPGGPPTPPG APPCLGMGLP LPQDPYPSSD VPLRKKRVPQ
PSHPLKSFNW VKLNEERVPG TVWNEIDDMQ VFRILDLEDF EKMFSAYQRH QELITNPSQQ
KELGSTEDIY LASRKVKELS VIDGRRAQNC IILLSKLKLS NEEIRQAILK MDEQEDLAKD
MLEQLLKFVP EKSDIDLLEE HKHEIERMAR ADRFLYEMSR IDHYQQRLQA LFFKKKFQER
LAEAKPKVEA ILLASRELVR SKRLRQMLEV ILAIGNFMNK GQRGGAYGFR VASLNKIADT
KSSIDRNISL LHYLIMILEK HFPDILNMPS ELQHLPEAAK VNLAELEKEV GNLRRGLRAV
EVELEYQRRQ VREPSDKFVP VMSDFITVSS FSFSELEDQL NEARDKFAKA LMHFGEHDSK
MQPDEFFGIF DTFLQAFSEA RQDLEAMRRR KEEEERRARM EAMLKEQRER ERWQRQRKVL
AAGSSLEEGG EFDDLVSALR SGEVFDKDLC KLKRSRKRSG SQALEVTRER AINRLNY
//
