UniProt: G3R173

Database: UniProt
Entry: G3R173_GORGO

LinkDB:  G3R173_GORGO 
Original site:  G3R173_GORGO

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Ontology (2)   
   GO (2)   
Gene (4)   
   NCBI-Gene (1)   
   ENSEMBL-UP (3)   
Protein sequence (2)   
   RefSeq(pep) (2)   
DNA sequence (5)   
   EMBL (5)   
Protein domain (26)   
   InterPro (13)   
   Pfam (4)   
   PROSITE (5)   
   SMART (4)   
Literature (1)   
   PubMed (1)   
All databases (40)   

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ID   G3R173_GORGO            Unreviewed;       858 AA.
AC   G3R173;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 2.
DT   27-MAR-2024, entry version 76.
DE   SubName: Full=Rap guanine nucleotide exchange factor 4 {ECO:0000313|Ensembl:ENSGGOP00000008927.4};
GN   Name=RAPGEF4 {ECO:0000313|Ensembl:ENSGGOP00000008927.4};
OS   Gorilla gorilla gorilla (Western lowland gorilla).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Gorilla.
OX   NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000008927.4, ECO:0000313|Proteomes:UP000001519};
RN   [1] {ECO:0000313|Ensembl:ENSGGOP00000008927.4, ECO:0000313|Proteomes:UP000001519}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Scally A.;
RT   "Insights into the evolution of the great apes provided by the gorilla
RT   genome.";
RL   Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSGGOP00000008927.4, ECO:0000313|Proteomes:UP000001519}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=22398555; DOI=10.1038/nature10842;
RA   Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA   Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA   McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA   Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA   Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA   Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA   Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA   Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA   Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA   Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA   Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA   Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA   Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT   "Insights into hominid evolution from the gorilla genome sequence.";
RL   Nature 483:169-175(2012).
RN   [3] {ECO:0000313|Ensembl:ENSGGOP00000008927.4}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   EMBL; CABD030017066; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030017067; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030017068; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030017069; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030017070; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_018878150.1; XM_019022605.1.
DR   RefSeq; XP_018878151.1; XM_019022606.1.
DR   AlphaFoldDB; G3R173; -.
DR   Ensembl; ENSGGOT00000009173.4; ENSGGOP00000008927.4; ENSGGOG00000009121.4.
DR   GeneID; 101151388; -.
DR   CTD; 11069; -.
DR   eggNOG; KOG2378; Eukaryota.
DR   GeneTree; ENSGT00940000156075; -.
DR   HOGENOM; CLU_006829_1_0_1; -.
DR   OrthoDB; 5473909at2759; -.
DR   TreeFam; TF313184; -.
DR   Proteomes; UP000001519; Chromosome 2B.
DR   Bgee; ENSGGOG00000009121; Expressed in prefrontal cortex and 5 other cell types or tissues.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR   CDD; cd00038; CAP_ED; 1.
DR   CDD; cd04437; DEP_Epac; 1.
DR   CDD; cd00155; RasGEF; 1.
DR   CDD; cd06224; REM; 1.
DR   Gene3D; 1.10.8.1240; -; 1.
DR   Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR   Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR   Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR000595; cNMP-bd_dom.
DR   InterPro; IPR018490; cNMP-bd_dom_sf.
DR   InterPro; IPR000591; DEP_dom.
DR   InterPro; IPR008937; Ras-like_GEF.
DR   InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR   InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR   InterPro; IPR023578; Ras_GEF_dom_sf.
DR   InterPro; IPR001895; RASGEF_cat_dom.
DR   InterPro; IPR036964; RASGEF_cat_dom_sf.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR   PANTHER; PTHR23113:SF175; RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 4; 1.
DR   Pfam; PF00027; cNMP_binding; 1.
DR   Pfam; PF00610; DEP; 1.
DR   Pfam; PF00617; RasGEF; 1.
DR   Pfam; PF00618; RasGEF_N; 1.
DR   PRINTS; PR00103; CAMPKINASE.
DR   SMART; SM00100; cNMP; 1.
DR   SMART; SM00049; DEP; 1.
DR   SMART; SM00147; RasGEF; 1.
DR   SMART; SM00229; RasGEFN; 1.
DR   SUPFAM; SSF51206; cAMP-binding domain-like; 1.
DR   SUPFAM; SSF48366; Ras GEF; 1.
DR   SUPFAM; SSF54236; Ubiquitin-like; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS50042; CNMP_BINDING_3; 1.
DR   PROSITE; PS50186; DEP; 1.
DR   PROSITE; PS00720; RASGEF; 1.
DR   PROSITE; PS50009; RASGEF_CAT; 1.
DR   PROSITE; PS50212; RASGEF_NTER; 1.
PE   4: Predicted;
KW   Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW   ECO:0000256|PROSITE-ProRule:PRU00168};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001519}.
FT   DOMAIN          63..138
FT                   /note="DEP"
FT                   /evidence="ECO:0000259|PROSITE:PS50186"
FT   DOMAIN          203..304
FT                   /note="Cyclic nucleotide-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS50042"
FT   DOMAIN          343..481
FT                   /note="N-terminal Ras-GEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50212"
FT   DOMAIN          619..856
FT                   /note="Ras-GEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50009"
SQ   SEQUENCE   858 AA;  98262 MW;  9D5175D0637DC0D0 CRC64;
     MAGLLAPPYG VMETGSNNDR IPDKENTPLI EPHVPLRPAN TITKVPSEKI LRAGKILRNA
     ILSRAPHMIR DRKYHLKTYR QCCVGTELVD WMMQQTPCVH SRTQAVGMWQ VLLEDGVLNH
     VDQEHHFQDK YLFYRFLDDE HEDAPLPTEE EKKECDEELQ DTMLLLSQMG PDAHMRMILR
     KPPGQRTVDD LEIIYEELLH IKALSHLSTT VKRELAGVLI FESHAKGGTV LFNQGEEGTS
     WYIILKGSVN VVIYGKGVVC TLHEGDDFGK LALVNDAPRA ASIVLREDNC HFLRVDKEDF
     NRILRDVEAN TVRLKEHDQD VLVLEKVPAG NRASNQGNSQ PQQKYTVMSG TPEKILEHFL
     ETIRLEATLN EATDSVLNDF IMMHCVFMPN TQLCPALVAH YHAQPSQGTE QEKMDYALNN
     KRRVIRLVLQ WAAMYGDLLQ EDDVSMAFLE EFYVSVSDDA RMIAALKEQL PELEKIVKQI
     SEDAKAPQKK HKVLLQQFNT GDERAQKRQP IRGSDEVLFK VYCMDHTYTT IRVPVATSVK
     EVISAVADKL GSGEGLIIVK MSSGGEKVVL KPNDVSVFTT LTINGRLFAC PREQFDSLTP
     LPEQEGPTVG TVATFELMSS KDLAYQMTIY DWELFNCVHE LELIYHTFGR HNFKKTTANL
     DLFLRRFNEI QFWVVTEICL CSQLSKRVQL LKKFIKIAAH CKEYKNLNSF FAIVMGLSNV
     AVSRLALTWE KLPSKFKKFY AEFESLMDPS RNHRAYRLTV AKLEPPLIPF MPLLIKDMTF
     THEGNKTFID NLVNFEKMRM IANTARTVRY YRSQPFNPDA AQANKNHQDV RSYVRQLNVI
     DNQRTLSQMS HRLEPRRP
//

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