ID G3R1U2_GORGO Unreviewed; 733 AA.
AC G3R1U2;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 74.
DE RecName: Full=Myotubularin-related protein 12 {ECO:0000256|ARBA:ARBA00018495};
DE AltName: Full=Inactive phosphatidylinositol 3-phosphatase 12 {ECO:0000256|ARBA:ARBA00033343};
GN Name=MTMR12 {ECO:0000313|Ensembl:ENSGGOP00000009174.3};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000009174.3, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000009174.3, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000009174.3, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000009174.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, myofibril, sarcomere
CC {ECO:0000256|ARBA:ARBA00004204}. Sarcoplasmic reticulum
CC {ECO:0000256|ARBA:ARBA00004369}.
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non-
CC receptor class myotubularin subfamily. {ECO:0000256|ARBA:ARBA00007471}.
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DR EMBL; CABD030105749; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030105750; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030105751; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030105752; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G3R1U2; -.
DR Ensembl; ENSGGOT00000009428.3; ENSGGOP00000009174.3; ENSGGOG00000009387.3.
DR eggNOG; KOG1089; Eukaryota.
DR GeneTree; ENSGT00940000160263; -.
DR HOGENOM; CLU_021912_2_0_1; -.
DR TreeFam; TF315197; -.
DR Proteomes; UP000001519; Chromosome 17.
DR Bgee; ENSGGOG00000009387; Expressed in cerebellum and 6 other cell types or tissues.
DR GO; GO:0030017; C:sarcomere; IEA:UniProtKB-SubCell.
DR GO; GO:0016529; C:sarcoplasmic reticulum; IEA:UniProtKB-SubCell.
DR CDD; cd14594; PTP-MTMR12; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR022587; MTMR12-like_C.
DR InterPro; IPR030576; MTMR12_PTP.
DR InterPro; IPR010569; Myotubularin-like_Pase_dom.
DR InterPro; IPR030564; Myotubularin_fam.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR PANTHER; PTHR10807; MYOTUBULARIN-RELATED; 1.
DR PANTHER; PTHR10807:SF37; MYOTUBULARIN-RELATED PROTEIN 12; 1.
DR Pfam; PF12578; 3-PAP; 1.
DR Pfam; PF06602; Myotub-related; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS51339; PPASE_MYOTUBULARIN; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW Sarcoplasmic reticulum {ECO:0000256|ARBA:ARBA00022951}.
FT DOMAIN 191..629
FT /note="Myotubularin phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS51339"
SQ SEQUENCE 733 AA; 84929 MW; 6086D0D0B4948B22 CRC64;
AGRGGTLLKP RVVLYVCPYV NRNSKEDLFW FLPGEQLLCE ASTVLKYVQE DSCQHGVYGR
LVCTDFKIAF LGDDESALDN DETQFKNKVI GENDITLHCV DQIYGVFDEK KKTLFGQLKK
YPEKLIIHCK DLRVFQFCLR YTKEEEVKRI VSGIIHHTQA PKLLKRLFLF SYATAAQNNT
VTDPKNHTVM FDTLKDWCWE LERTKGNMKY KAVSVNEGYK VCERLPAYFV VPTPLPEENV
QRFQGHGIPI WCWSCHNGSA LLKMSALPKE QDDGILQIQK SFLDGIYKTI HRPPYEVVKT
EDLSSNFLSL QEIQTAYSKF KQLFLIDNST EFWDTDIKWF SLLESSSWLD IIRRCLKKAI
EITECMEAQN MNVLLLEENA SDLCCLISSL VQLMMDPHCR TRIGFQSLIQ KEWVMGGHCF
LDRCNHLRQN DKEEVPVFLL FLDCVWQLVH QHPPAFEFTE TYLTVLSDSL YIPIFSTFFF
NSPHQKDTNM GREGQDTQSK PLNLLTVWDW SVQFEPKAQT LLKNPLYVEK PKLDKGQRKG
MRFKHQRQLS LPLTQSKSSP KRGFFREETD HLIKNLLGKR ISKLINSSDE LQDNFREFYD
SWHSKSTDYH GLLLPHIEGP EIKVWAQRYL RWIPEAQILG GGQVATMSKL LEMMEEVQSL
QEKIDERHHS QQAPQAEGPC LLRNSARLSS LFPFALLQRH SSKPVLPTSG WKALGDEDDL
AKREDEFVDL GDV
//
