UniProt: G3R4K4

Database: UniProt
Entry: G3R4K4_GORGO

LinkDB:  G3R4K4_GORGO 
Original site:  G3R4K4_GORGO

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Ontology (18)   
   GO (18)   
Gene (3)   
   ENSEMBL-UP (3)   
DNA sequence (9)   
   EMBL (9)   
Protein domain (39)   
   InterPro (14)   
   Pfam (6)   
   PROSITE (9)   
   SMART (10)   
Literature (1)   
   PubMed (1)   
All databases (70)   

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ID   G3R4K4_GORGO            Unreviewed;      1530 AA.
AC   G3R4K4;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 2.
DT   27-MAR-2024, entry version 88.
DE   SubName: Full=Slit guidance ligand 3 {ECO:0000313|Ensembl:ENSGGOP00000010210.3};
GN   Name=SLIT3 {ECO:0000313|Ensembl:ENSGGOP00000010210.3};
OS   Gorilla gorilla gorilla (Western lowland gorilla).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Gorilla.
OX   NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000010210.3, ECO:0000313|Proteomes:UP000001519};
RN   [1] {ECO:0000313|Ensembl:ENSGGOP00000010210.3, ECO:0000313|Proteomes:UP000001519}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Scally A.;
RT   "Insights into the evolution of the great apes provided by the gorilla
RT   genome.";
RL   Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSGGOP00000010210.3, ECO:0000313|Proteomes:UP000001519}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=22398555; DOI=10.1038/nature10842;
RA   Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA   Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA   McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA   Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA   Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA   Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA   Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA   Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA   Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA   Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA   Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA   Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA   Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT   "Insights into hominid evolution from the gorilla genome sequence.";
RL   Nature 483:169-175(2012).
RN   [3] {ECO:0000313|Ensembl:ENSGGOP00000010210.3}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR   EMBL; CABD030042256; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030042257; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030042258; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030042259; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030042260; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030042261; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030042262; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030042263; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030042264; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 9593.ENSGGOP00000010210; -.
DR   Ensembl; ENSGGOT00000010509.3; ENSGGOP00000010210.3; ENSGGOG00000010444.3.
DR   GeneTree; ENSGT00940000159322; -.
DR   HOGENOM; CLU_001431_2_0_1; -.
DR   InParanoid; G3R4K4; -.
DR   OMA; PACNANS; -.
DR   Proteomes; UP000001519; Chromosome 5.
DR   Bgee; ENSGGOG00000010444; Expressed in heart and 5 other cell types or tissues.
DR   GO; GO:0005615; C:extracellular space; IEA:Ensembl.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0008201; F:heparin binding; IBA:GO_Central.
DR   GO; GO:0048495; F:Roundabout binding; IBA:GO_Central.
DR   GO; GO:0003180; P:aortic valve morphogenesis; IEA:Ensembl.
DR   GO; GO:0061364; P:apoptotic process involved in luteolysis; IEA:Ensembl.
DR   GO; GO:0003181; P:atrioventricular valve morphogenesis; IEA:Ensembl.
DR   GO; GO:0048846; P:axon extension involved in axon guidance; IEA:Ensembl.
DR   GO; GO:0007411; P:axon guidance; IBA:GO_Central.
DR   GO; GO:0032870; P:cellular response to hormone stimulus; IEA:Ensembl.
DR   GO; GO:0050919; P:negative chemotaxis; IBA:GO_Central.
DR   GO; GO:0030308; P:negative regulation of cell growth; IEA:Ensembl.
DR   GO; GO:0008285; P:negative regulation of cell population proliferation; IEA:Ensembl.
DR   GO; GO:0070100; P:negative regulation of chemokine-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:0010629; P:negative regulation of gene expression; IEA:Ensembl.
DR   GO; GO:0051414; P:response to cortisol; IEA:Ensembl.
DR   GO; GO:0035385; P:Roundabout signaling pathway; IEA:Ensembl.
DR   GO; GO:0060412; P:ventricular septum morphogenesis; IEA:Ensembl.
DR   CDD; cd00054; EGF_CA; 5.
DR   CDD; cd00110; LamG; 1.
DR   Gene3D; 2.60.120.200; -; 1.
DR   Gene3D; 2.10.25.10; Laminin; 8.
DR   Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 5.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR000483; Cys-rich_flank_reg_C.
DR   InterPro; IPR006207; Cys_knot_C.
DR   InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR   InterPro; IPR013032; EGF-like_CS.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR   InterPro; IPR018097; EGF_Ca-bd_CS.
DR   InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR   InterPro; IPR001791; Laminin_G.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR000372; LRRNT.
DR   PANTHER; PTHR45836:SF23; LRRCT DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR45836; SLIT HOMOLOG; 1.
DR   Pfam; PF00008; EGF; 5.
DR   Pfam; PF12661; hEGF; 1.
DR   Pfam; PF02210; Laminin_G_2; 1.
DR   Pfam; PF13855; LRR_8; 5.
DR   Pfam; PF01463; LRRCT; 4.
DR   Pfam; PF01462; LRRNT; 3.
DR   SMART; SM00041; CT; 1.
DR   SMART; SM00181; EGF; 9.
DR   SMART; SM00179; EGF_CA; 8.
DR   SMART; SM00282; LamG; 1.
DR   SMART; SM00364; LRR_BAC; 5.
DR   SMART; SM00368; LRR_RI; 6.
DR   SMART; SM00365; LRR_SD22; 9.
DR   SMART; SM00369; LRR_TYP; 18.
DR   SMART; SM00082; LRRCT; 4.
DR   SMART; SM00013; LRRNT; 4.
DR   SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR   SUPFAM; SSF57196; EGF/Laminin; 5.
DR   SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR   SUPFAM; SSF52058; L domain-like; 2.
DR   PROSITE; PS00010; ASX_HYDROXYL; 2.
DR   PROSITE; PS01185; CTCK_1; 1.
DR   PROSITE; PS01225; CTCK_2; 1.
DR   PROSITE; PS00022; EGF_1; 9.
DR   PROSITE; PS01186; EGF_2; 7.
DR   PROSITE; PS50026; EGF_3; 8.
DR   PROSITE; PS01187; EGF_CA; 2.
DR   PROSITE; PS50025; LAM_G_DOMAIN; 1.
DR   PROSITE; PS51450; LRR; 5.
PE   4: Predicted;
KW   Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW   Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW   ProRule:PRU00076};
KW   EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW   ProRule:PRU00076}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW   Neurogenesis {ECO:0000256|ARBA:ARBA00022902};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..33
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           34..1530
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5014193891"
FT   DOMAIN          925..960
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          962..1001
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          1003..1039
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          1041..1079
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          1081..1117
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          1126..1162
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          1165..1339
FT                   /note="Laminin G"
FT                   /evidence="ECO:0000259|PROSITE:PS50025"
FT   DOMAIN          1375..1410
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          1415..1451
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          1456..1530
FT                   /note="CTCK"
FT                   /evidence="ECO:0000259|PROSITE:PS01225"
FT   DISULFID        950..959
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT   DISULFID        991..1000
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT   DISULFID        1029..1038
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT   DISULFID        1069..1078
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT   DISULFID        1107..1116
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT   DISULFID        1152..1161
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT   DISULFID        1312..1339
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00122"
FT   DISULFID        1379..1389
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT   DISULFID        1400..1409
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT   DISULFID        1419..1429
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT   DISULFID        1441..1450
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ   SEQUENCE   1530 AA;  168460 MW;  87FD9373D0ED8D51 CRC64;
     MAPGWAGVGA AVRARLALAL ALASVLSGPP AVACPTKCTC SAASVDCHGL GLRAVPRGIP
     RNAERLDLDR NNITRITKMD FAGLKNLRVL HLEDNQVSVI ERGAFQDLKQ LERLRLNKNK
     LQVLPELLFQ STPKLTRLDL SENQIQGIPR KAFRGITDVK NLQLDNNHIS CIEDGAFRAL
     RDLEILTLNN NNISRILVTS FNHMPKIRTL RLHSNHLYCD CHLAWLSDWL RQRRTVGQFT
     LCMAPVHLRG FNVADVQKKE YVCPAPHSEP PSCNANSISC PSPCTCSNNI VDCRGKGLME
     IPANLPEGIV EIRLEQNSIK AIPAGAFTQY KKLKRIDISK NQISDIAPDA FQGLKSLTSL
     VLYGNKITEI AKGLFDGLVS LQLLLLNANK INCLRVNTFQ DLQNLNLLSL YDNKLQTISK
     GLFAPLQSIQ TLHLAQNPFV CDCHLKWLAD YLQDNPIETS GARCSSPRRL ANKRISQIKS
     KKFRCSGSED YRSRFSSECF MDLVCPEKCR CEGTIVDCSN QKLARIPSHL PEYVTDLRLN
     DNEVSVLEAT GIFKKLPNLR KINLSNNKIK EVREGAFDGA ASVQELMLTG NQLETVHGRV
     FRGLSGLKTL MLRSNLISCV SNDTFAGLSS VRLLSLYDNR ITTITPGAFT TLVSLSTINL
     LSNPFNCNCH LAWLGKWLRK RRIVSGNPRC QKPFFLKEIP IQDVAIQDFT CDGNDESSCQ
     LSPRCPEQCT CMETVVRCSN KGLRALPKGM PKDVTELYLE GNHLTAVPRE LSTLRHLTLI
     DLSNNSISML TNYTFSNMSH LSTLILSYNR LRCIPVHAFN GLRSLRVLTL HGNDISSVPE
     GSFNDLTSLS HLALGTNPLH CDCSLRWLSE WVKAGYKEPG IARCSSPEPM ADRLLLTTPT
     HRFQCKVLWF CCPGPVDINI VAKCNACLSS PCKNNGTCTQ DPVELYRCAC PYSYKGKDCT
     VPINTCIQNP CQHGGTCHLS DSHKDGFSCS CPLGFEGQQC EINPDDCEDN DCENNATCVD
     GINNYVCICP PNYTGELCDE VIDHCVPELN LCQHEAKCIP LDKGFRCECV PGYSGKLCET
     DNDDCVAHKC RHGAQCVDTI NGYTCTCPQG FSGPFCEHPP PMVLLQTSPC DQYECQNGAQ
     CIVVQQEPTC RCPPGFAGPR CEKLITVNFV GKDSYVELAS AKVRPQANIS LQVATDKDNG
     ILLYKGDNDP LALELYQGHV RLVYDSLSSP PTTVYSVETV NDGQFHSVEL VTLNQTLNLV
     VDKGTPKSLG KLQKQPTVGI NSPLYLGGIP TSTGLSALRQ GTDRPLGGFH GCIHEVRINN
     ELQDFKALPP QSLGVSPGCK SCTVCKHGLC RSVEKDSVVC ECHSGWTGPL CDQEARDPCL
     SHSCNHGKCV ATGTSYMCKC AEGYGGALCD NKNDSANACS AFKCHHGQCH ISDQGEPYCL
     CQPGFSGEHC QQENPCLGQV VREVIRRQKG YASCATASKV PIMECRGGCG PQCCQPTRSK
     RRKYVFQCTD GSSFVEEVER HLECGCLACS
//

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