GenomeNet

Database: UniProt
Entry: G3R4X7_GORGO
LinkDB: G3R4X7_GORGO
Original site: G3R4X7_GORGO 
ID   G3R4X7_GORGO            Unreviewed;       547 AA.
AC   G3R4X7;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 2.
DT   28-MAR-2018, entry version 44.
DE   SubName: Full=Two pore segment channel 2 {ECO:0000313|Ensembl:ENSGGOP00000010343};
GN   Name=TPCN2 {ECO:0000313|Ensembl:ENSGGOP00000010343};
OS   Gorilla gorilla gorilla (Western lowland gorilla).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Gorilla.
OX   NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000010343, ECO:0000313|Proteomes:UP000001519};
RN   [1] {ECO:0000313|Ensembl:ENSGGOP00000010343, ECO:0000313|Proteomes:UP000001519}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Scally A.;
RT   "Insights into the evolution of the great apes provided by the gorilla
RT   genome.";
RL   Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSGGOP00000010343}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
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DR   EMBL; CABD030079978; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030079979; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSGGOT00000010647; ENSGGOP00000010343; ENSGGOG00000010594.
DR   GeneTree; ENSGT00530000063660; -.
DR   Proteomes; UP000001519; Chromosome 11.
DR   Bgee; ENSGGOG00000010594; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005765; C:lysosomal membrane; IEA:InterPro.
DR   GO; GO:0072345; F:NAADP-sensitive calcium-release channel activity; IEA:InterPro.
DR   GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR   Gene3D; 1.20.120.350; -; 2.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR028798; TPC2.
DR   InterPro; IPR027359; Volt_channel_dom_sf.
DR   PANTHER; PTHR10037:SF92; PTHR10037:SF92; 1.
DR   Pfam; PF00520; Ion_trans; 2.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001519};
KW   Membrane {ECO:0000256|SAAS:SAAS00085096, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00084820,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00084701,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     44     62       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    119    142       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    182    202       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    250    275       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    399    418       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    430    449       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       54    278       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      394    475       Ion_trans. {ECO:0000259|Pfam:PF00520}.
SQ   SEQUENCE   547 AA;  61708 MW;  95E937709426181D CRC64;
     AAARWDLCID QAVVFIEDAI QYRSINHRVD ASSMWLYRRY YSNVCQRTLS FTIFLILFLA
     FIETPSSLTS TADVRYRAAP WEPPCGLTES VEVLCLLVFA ADLSVKGYLF GWAHFQKNLW
     LLGYLVVLVV SLVDWTVSLS LVCHEPLRIR RLLRPFFLLQ NSSMMKKTLK CIRWSLPEMA
     SVGLLLAIHL CLFTMFGMLL FAGGKQDDGQ DRERLTYFQN LPESLTSLLV LLTTANNPDV
     MIPAYSKNRA YAIFFIVFTV IGSLFLMNLL TAIIYSQFRG YLMKSLQTSL FRRRLGTRAA
     FEVLSSMVGE GGAFPQAVGV KPQNLLQVLR KVQLDSSHKQ AMMEKVRSYG SVLLSAEEFQ
     KLFNELDRSV VKEHPPRPGY QSPFLQSAQF LFGHYYFDYL GNLIALANLV TICVFLVLDA
     DVLPAERDDF ILGILNCVFI VYYLLEMLLK VFALGLRGYL SYPSNVFDGL LTIVLLEAGD
     AGPAVAVGHD PHAEHAHRVP LPAYHPQHEA DGRGGQYRPG PGAEHACVWR DPGGGLLRIC
     HHWDQLV
//
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