ID G3R545_GORGO Unreviewed; 550 AA.
AC G3R545;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 60.
DE SubName: Full=Cdk5 and Abl enzyme substrate 1 {ECO:0000313|Ensembl:ENSGGOP00000010412.3};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000010412.3, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000010412.3, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000010412.3, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000010412.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; CABD030108603; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030108604; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030108605; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G3R545; -.
DR STRING; 9593.ENSGGOP00000010412; -.
DR Ensembl; ENSGGOT00000010717.3; ENSGGOP00000010412.3; ENSGGOG00000010671.3.
DR eggNOG; KOG4164; Eukaryota.
DR GeneTree; ENSGT00400000022086; -.
DR HOGENOM; CLU_021942_2_0_1; -.
DR InParanoid; G3R545; -.
DR OMA; EQWQLPR; -.
DR TreeFam; TF323936; -.
DR Proteomes; UP000001519; Chromosome 18.
DR Bgee; ENSGGOG00000010671; Expressed in prefrontal cortex and 5 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0007399; P:nervous system development; IBA:GO_Central.
DR GO; GO:0051726; P:regulation of cell cycle; IEA:InterPro.
DR CDD; cd20602; CYCLIN_CABLES1; 1.
DR Gene3D; 1.10.472.10; Cyclin-like; 1.
DR InterPro; IPR012388; CABLES1/2.
DR InterPro; IPR036915; Cyclin-like_sf.
DR InterPro; IPR006671; Cyclin_N.
DR PANTHER; PTHR22896; CDK5 AND ABL1 ENZYME SUBSTRATE 1; 1.
DR PANTHER; PTHR22896:SF1; CDK5 AND ABL1 ENZYME SUBSTRATE 1; 1.
DR Pfam; PF00134; Cyclin_N; 1.
DR PIRSF; PIRSF025798; Cables; 1.
DR SUPFAM; SSF47954; Cyclin-like; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001519}.
FT DOMAIN 444..532
FT /note="Cyclin N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00134"
SQ SEQUENCE 550 AA; 59298 MW; 118293D9DE916A74 CRC64;
MAAAGEEGGA AKPGAGGACG ARTRFSLLAA AERGGCIALA APGTPAAGLA AGSGPCLPQP
SSLPPLIPGG HATVSGPGVA RGFASPLGAG RASGEQWQPP RPAPLAVCAQ LQLLDGSGAA
GQEELEEDDA FISVQVPAAA FLGSGTPGSG SGSRGRLNSF TQGILPIAFS RPTSQNYCSL
EQPGQGGSTS AFEQLQRSRR RLISQRSSLE TLEDIEENAP LRRCRTLSGS PRPKNFKKIH
FIKNMRQHDT RNGRIVLISG RRSFCSIFSV LPYRDSTQVG DLKLDGGRQS TGAVSLKEII
GLEGVELGAD GKTVSYTQFL LPTNAFGARR NTIDSTSSFS QFRNLSHRSL SIGRASGTQG
SLDTGSDLGD FMDYDPNLLD DPQWPCGKHK RVLIFPSYMT TVIDYVKPSD LKKDMNETFK
EKFPHIKLTL SKIRSLKREM RKLAQEDCGL EEPTVAMAFV YFEKLALKGK LNKQNRKLCA
GACVLLAAKI GSDLKKHEVK HLIDKLEEKF RLNRRELIAF EFPVLVALEF ALHLPEHEVM
PHYRRLVQSS
//
