ID G3R598_GORGO Unreviewed; 790 AA.
AC G3R598;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=SH3 domain containing 19 {ECO:0000313|Ensembl:ENSGGOP00000010468.3};
GN Name=SH3D19 {ECO:0000313|Ensembl:ENSGGOP00000010468.3};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000010468.3, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000010468.3, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000010468.3, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000010468.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; CABD030034239; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030034240; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030034241; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030034242; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030034243; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030034244; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030034245; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030034246; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030034247; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030034248; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_018880712.1; XM_019025167.1.
DR RefSeq; XP_018880713.1; XM_019025168.1.
DR RefSeq; XP_018880714.1; XM_019025169.1.
DR AlphaFoldDB; G3R598; -.
DR Ensembl; ENSGGOT00000010776.3; ENSGGOP00000010468.3; ENSGGOG00000010733.3.
DR eggNOG; KOG4225; Eukaryota.
DR GeneTree; ENSGT00940000155694; -.
DR HOGENOM; CLU_015305_2_0_1; -.
DR OrthoDB; 2920126at2759; -.
DR TreeFam; TF330850; -.
DR Proteomes; UP000001519; Chromosome 4.
DR Bgee; ENSGGOG00000010733; Expressed in heart and 6 other cell types or tissues.
DR CDD; cd11814; SH3_Eve1_1; 1.
DR CDD; cd11815; SH3_Eve1_2; 1.
DR CDD; cd11816; SH3_Eve1_3; 1.
DR CDD; cd11817; SH3_Eve1_4; 1.
DR CDD; cd11818; SH3_Eve1_5; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 4.
DR InterPro; IPR035834; Eve1_SH3_1.
DR InterPro; IPR035835; Eve1_SH3_3.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR45929; JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE; 1.
DR Pfam; PF00018; SH3_1; 3.
DR Pfam; PF07653; SH3_2; 1.
DR Pfam; PF14604; SH3_9; 1.
DR PRINTS; PR00499; P67PHOX.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00326; SH3; 5.
DR SUPFAM; SSF50044; SH3-domain; 5.
DR PROSITE; PS50002; SH3; 5.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 415..477
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 495..554
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 571..630
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 661..720
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 730..789
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 21..196
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 241..374
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 286..311
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 320..351
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 360..374
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 790 AA; 86526 MW; F7D7A528789EB1AF CRC64;
MNIMNTEQSQ NSIVSRIKVF EGQTNIETSG LPKKPEITPR SLPPKPTVSS GKPSVAPKPA
ANRASGEWDS GTENRLKVTS KEGLTPYPPL QEAGSIPATK PELPKKPNPG LIRSVNPEIP
GRGPLAESSD SGKKVPTPAP RPLLLKKSVS SENPTYPSAP LKPVTVPPRL AGASQAKAYK
SLGEGPPANP PVPVLQSKPL VDIDLISFDD DVLPTPSGNL AEESVGSEMV LDPFQLPAKT
EPIKERAVQP APTRKPTVIR IPAKPGKCLH EDPQSPPPLP AEKPIGNTFS TVSGKLSNVE
RTRNLESNHP GQTGGFVRGP PRLPPRPVNG KTIPTQQPPT KVPPERPPPP KLSAIRRSNK
KLPFNRSSSD MDLQKKQSNL ATGLSKAKSQ VFKNQDPVLP PRPKPGHPLY SKYMLSVLHG
IANEDIVSQN PGELSCKRGD VLVMLKQTEN NYLECQKGED TGRVHLSQMK IITPLDEHLR
SRPNDPSHAQ KPVDSGAPHA VVLHDFPAEQ VDDLNLTSGE IVYLLEKIDT DWYRGNCRNQ
IGIFPANYVK VIIDIPEGGN GKRECVSSHC VKGSRCVARF EYIGEQKDEL SFSEGEIIIL
KEYVNEEWAR GEVRGRTGIF PLNFVEPVED YPTSGANVLS TKVPLKTKKE DSGSNSQVNS
LSAEWCEALH SFTAETSDDL SFKRGDRIQI LERLDSDWWR GRLQDREGIF PAVFVRPCPA
EAKSTLAIVP KGRKAKALYD FRGENEDELS FKAGDIITEL ESVDDDWMSG ELMGKSGIFP
KNYIQFLQIS
//
