ID G3R5N8_GORGO Unreviewed; 97 AA.
AC G3R5N8;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=Defensin alpha 4 {ECO:0000313|Ensembl:ENSGGOP00000010619.2};
GN Name=DEFA4 {ECO:0000313|Ensembl:ENSGGOP00000010619.2};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000010619.2, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000010619.2, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000010619.2, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000010619.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the alpha-defensin family.
CC {ECO:0000256|ARBA:ARBA00006519}.
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DR EMBL; CABD030056770; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_004046637.1; XM_004046589.1.
DR RefSeq; XP_018887567.1; XM_019032022.1.
DR AlphaFoldDB; G3R5N8; -.
DR STRING; 9593.ENSGGOP00000010619; -.
DR Ensembl; ENSGGOT00000010936.3; ENSGGOP00000010619.2; ENSGGOG00000010900.3.
DR GeneID; 101150241; -.
DR KEGG; ggo:101150241; -.
DR CTD; 1669; -.
DR eggNOG; ENOG502T2EX; Eukaryota.
DR GeneTree; ENSGT00940000153268; -.
DR HOGENOM; CLU_160803_0_0_1; -.
DR InParanoid; G3R5N8; -.
DR OMA; CQRTELR; -.
DR OrthoDB; 5266470at2759; -.
DR TreeFam; TF338414; -.
DR Proteomes; UP000001519; Chromosome 8.
DR GO; GO:0042582; C:azurophil granule; IEA:Ensembl.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005796; C:Golgi lumen; IEA:UniProt.
DR GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
DR GO; GO:0019731; P:antibacterial humoral response; IBA:GO_Central.
DR GO; GO:0019732; P:antifungal humoral response; IEA:Ensembl.
DR GO; GO:0061844; P:antimicrobial humoral immune response mediated by antimicrobial peptide; IBA:GO_Central.
DR GO; GO:0071222; P:cellular response to lipopolysaccharide; IBA:GO_Central.
DR GO; GO:0050829; P:defense response to Gram-negative bacterium; IBA:GO_Central.
DR GO; GO:0050830; P:defense response to Gram-positive bacterium; IBA:GO_Central.
DR GO; GO:0051673; P:disruption of plasma membrane integrity in another organism; IBA:GO_Central.
DR GO; GO:0002227; P:innate immune response in mucosa; IBA:GO_Central.
DR GO; GO:0031640; P:killing of cells of another organism; IEA:UniProtKB-KW.
DR InterPro; IPR016327; Alpha-defensin.
DR InterPro; IPR006081; Alpha-defensin_C.
DR InterPro; IPR002366; Alpha-defensin_N.
DR InterPro; IPR006080; Beta/alpha-defensin_C.
DR PANTHER; PTHR11876; ALPHA-DEFENSIN 1; 1.
DR PANTHER; PTHR11876:SF23; DEFENSIN ALPHA 4; 1.
DR Pfam; PF00323; Defensin_1; 1.
DR Pfam; PF00879; Defensin_propep; 1.
DR PIRSF; PIRSF001875; Alpha-defensin; 1.
DR SMART; SM01418; Defensin_propep; 1.
DR SMART; SM00048; DEFSN; 1.
DR PROSITE; PS00269; DEFENSIN; 1.
PE 3: Inferred from homology;
KW Antibiotic {ECO:0000256|ARBA:ARBA00023022};
KW Antimicrobial {ECO:0000256|ARBA:ARBA00022529};
KW Defensin {ECO:0000256|ARBA:ARBA00022940};
KW Fungicide {ECO:0000256|ARBA:ARBA00022577};
KW Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..97
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003452193"
FT DOMAIN 65..93
FT /note="Mammalian defensins"
FT /evidence="ECO:0000259|PROSITE:PS00269"
SQ SEQUENCE 97 AA; 10447 MW; 5019B0C93D7C2ECC CRC64;
MRIIALLAAI LLVALQVQAG PLQARGDEAP GQELRGPDDQ DISISFAWDK SSALQVSGST
RGMVCSCRLV FCRRTELRVG NCLIGGVSFT YCCTRVD
//
