ID G3R655_GORGO Unreviewed; 1344 AA.
AC G3R655;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=Rho guanine nucleotide exchange factor 10 {ECO:0000313|Ensembl:ENSGGOP00000010794.3};
GN Name=ARHGEF10 {ECO:0000313|Ensembl:ENSGGOP00000010794.3};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000010794.3, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000010794.3, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000010794.3, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000010794.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CABD030056576; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030056577; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030056578; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030056579; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030056580; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030056581; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_004046619.2; XM_004046571.2.
DR Ensembl; ENSGGOT00000011115.3; ENSGGOP00000010794.3; ENSGGOG00000011064.3.
DR GeneID; 101138491; -.
DR KEGG; ggo:101138491; -.
DR CTD; 9639; -.
DR GeneTree; ENSGT00940000153798; -.
DR HOGENOM; CLU_001213_1_0_1; -.
DR OrthoDB; 2916834at2759; -.
DR Proteomes; UP000001519; Chromosome 8.
DR Bgee; ENSGGOG00000011064; Expressed in testis and 6 other cell types or tissues.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR039919; ARHGEF10/ARHGEF17.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR12877; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR12877:SF14; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 10; 1.
DR Pfam; PF19057; PH_19; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF19056; WD40_2; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50010; DH_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000001519}.
FT DOMAIN 396..583
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT REGION 1..74
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 155..242
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1201..1235
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1252..1272
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 279..330
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 566..597
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 168..182
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1201..1223
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1252..1270
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1344 AA; 149098 MW; D54581ECF7FB8163 CRC64;
MDQREPLPPA PAENEMKYDT NNNEEEEGEQ FDFDSGDEIP EADRQAPSAP ETGGAGASEA
PAPTGGEDGA GAETTPVVEP TKLVLPMKVN PYSVIDITPF QEDQPPTPVP SAEEENVGLH
VPCGYLVPVP CGYAVPSNLP LLLPAYSSPV IIRTTSLDEE ETPEVTEDRQ PNSLSSEEPP
TSEDQVGPED SALARWAADP ANTAWMENPE EAIYDDVPRE NSDSEPDEMI YDDVENGDEG
GNSSLEYGWS SSEFESYEEQ SDSECKNGIP RSFLRSNHKK QLSHDLTRLK EHYEKKMRDL
MASTVGVVEI QQLRQKHELK MQKLVKAAKD GTKDGLERTR AAVKRGRSFI RTKSLIAQDQ
RSSLEEEQNL FIDVDCKHPE AILTPMPEGL SQQQVVRRYI LGSVVDSEKN YVDALKRILE
QYEKPLSEME PKVLSERKLK TVFYRVKEIL QCHSLFQIAL ASRVSEWDSV EMIGDVFVAS
FSKSMVLDAY SEYVNNFSTA VAVLKKTCAT KPAFLEFLKQ EQEASPDRTT LYSLMMKPIQ
RFPQFILLLQ DMLKNTSKGH PDRLPLQMAL TELETLAEKL NERKRDADQR CEVKQIAKAI
NERYLNKLLS TGSRYLIRSD DMIETVYNDR GEIVKTKERR VFMLNDVLMC ATVSSRRSHD
SRVMSSQRYL LKWSVPLGHV DAIEYGSSPG TGEHSRHLAV HPPESLAVVA NAKPNKVYMG
PGQLYQDLQN LLHDLNVIGQ ITQLIGNLKG NYQNLNQSVA HDWTSGLQRL ILKKEDEIRA
ADCCRIQLQL PGKQDKSGRP TFFTAVFNTF TPAIKESWVN SLQMAKLALE EENHMGWFCV
EDDGNHIKKE KHPLLVGHMP VMVAKQQEFK IECAAYNPEP YLNNESQPDS FSTAHGFLWI
GSCTHQMGQI AIISFQNSTP KVIECFNVES RILCMLYVPV EEKRREPGAP PDPETPAVRA
SDVPTICVGT EEGSISIYKS SQGSKKVRLQ HFFTPEKSTV MSLACTSQSL YAGLVNGAVA
SYARAPDGSW DSEPQKVIKL GVLPVRSLLM MEDTLWAASG GQVFIISVET HAVEGQLEAH
QEEGMVISHM AVSGVGIWIA FTSGSTLRLF HTETLKHLQD INIATPVHNM LPGHQRLSVT
SLLVCHGLLM VGTSLGVLVA LPVPRLQGIP KVTGRGMVSY HAHNSPVKFI VLATALHEKD
KDKSRDSLAP GPEPQDEDQK DALPSEGAGS SLSQGDPDAA IWLGDSLGSM TQKSDLSSSS
GSLSLSHGSS SLEHRSEDST IYDLLKDPVS LRSKARRAKK AKASSALVVC GGQGHRRVHR
KARQPHQEEL APTVMVWQIP LLNI
//
