ID G3R6K5_GORGO Unreviewed; 2132 AA.
AC G3R6K5;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 76.
DE SubName: Full=ATP binding cassette subfamily A member 7 {ECO:0000313|Ensembl:ENSGGOP00000010964.3};
GN Name=ABCA7 {ECO:0000313|Ensembl:ENSGGOP00000010964.3};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000010964.3, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000010964.3, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000010964.3, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000010964.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; CABD030110526; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030110527; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030110528; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030110529; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030110530; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030110531; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 9593.ENSGGOP00000010964; -.
DR Ensembl; ENSGGOT00000011288.3; ENSGGOP00000010964.3; ENSGGOG00000011229.3.
DR eggNOG; KOG0059; Eukaryota.
DR GeneTree; ENSGT00940000161439; -.
DR HOGENOM; CLU_000604_19_0_1; -.
DR InParanoid; G3R6K5; -.
DR OMA; AQEPLHS; -.
DR TreeFam; TF105191; -.
DR Proteomes; UP000001519; Chromosome 19.
DR Bgee; ENSGGOG00000011229; Expressed in heart and 5 other cell types or tissues.
DR GO; GO:0030054; C:cell junction; IEA:Ensembl.
DR GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0034188; F:apolipoprotein A-I receptor activity; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0042626; F:ATPase-coupled transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0090554; F:phosphatidylcholine floppase activity; IBA:GO_Central.
DR GO; GO:0090556; F:phosphatidylserine floppase activity; IBA:GO_Central.
DR GO; GO:0034205; P:amyloid-beta formation; IEA:Ensembl.
DR GO; GO:0033344; P:cholesterol efflux; IBA:GO_Central.
DR GO; GO:0034380; P:high-density lipoprotein particle assembly; IEA:Ensembl.
DR GO; GO:0033700; P:phospholipid efflux; IBA:GO_Central.
DR GO; GO:0045332; P:phospholipid translocation; IEA:Ensembl.
DR GO; GO:1902991; P:regulation of amyloid precursor protein catabolic process; IEA:Ensembl.
DR CDD; cd03263; ABC_subfamily_A; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR013525; ABC2_TM.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR026082; ABCA.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR19229; ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA; 1.
DR PANTHER; PTHR19229:SF49; PHOSPHOLIPID-TRANSPORTING ATPASE ABCA7; 1.
DR Pfam; PF12698; ABC2_membrane_3; 2.
DR Pfam; PF00005; ABC_tran; 2.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW Translocase {ECO:0000256|ARBA:ARBA00022967};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 542..562
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 582..606
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 618..638
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 645..665
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1225..1246
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1522..1544
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1564..1590
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1602..1621
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1633..1657
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1720..1738
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 799..1030
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT DOMAIN 1779..2011
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT REGION 1172..1192
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2090..2132
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2132 AA; 232835 MW; A2B49502B2C05904 CRC64;
MAFWTQLMLL LWKNFMYRRR QPVQLLVELL WPLFLFFILV AVRHSHPPLE HHECHFPNKP
LPSGLICNVN NTCFPQLTPG EEPGRLSNFN DSLVSRLLAD ARTVLGGASA HRTLAGLGKL
IATLRAARST AQPQPTKQSP LEPPMLDVAE LLTSLLRTES LGLVLGRAQE PLHSLLEAAE
DLAQELLALR SLVELQALLR RPRGTSGPLE LLSEALCSAR GPSSTVGPSL NWYEASDLME
LVGQEPESAL PDSSLSPACS ELIGALDSHS LSRLLWRRLK PLILGKLLFA PDTPFTRKLM
AQVNRTFEEL ALLRDVREVW EMLGPRIFTF MNDSSNVAML QRLLQMQDEG RRQPRPGGRE
HMEALRSFLD PGSGGYSWQD AHADVGRLVG TLGRVTECLS LDKLEAAPSE AALVSRALQL
LAEHRFWAGI VFLGPEDSSD PTEHPTPDLG PGHVRIKIRM DIDVVTRTNK IRDRFWDPGP
AADPLTDLRY VWGGFVYLQD LVERAAVRVL SGANPRAGLY LQQMPYPCYV DDVFLRVLSR
SLPLFLTLAW IYSVTLTVKA VVREKETRLR DTMRAMGLSR AVLWLGWFLS CLGPFLLSAA
LLVLVLKLGD ILPYSHPGVV FLFLAAFAVA TVTQSFLLSA FFSRANLAAA CGGLAYFSLY
LPYVLCVAWR DRLPAGGRVA ASLLSPVAFG FGCESLALLE EQGEGAQWHN VGTRPTADVF
SLAQVSGLLL LDAALYGLAT WYLEAVCPGQ YGIPEPWNFP FRRSYWCGPQ PPKSPAPCPT
PLDPKVLVEE APPGLSPGVS VRGLEKRFPG SPQPALRGLS LDFYQGHITA FLGHNGAGKT
TTLSILSGLF PPSGGSAFIL GHDVRSSMAA IRPHLGVCPQ YNVLFDMLTV GEHVWFYGRL
KGLSAAVVGP EQGRLLQDVG LVSKQSVQTR HLSGGMQRKL SVAIAFVGGS QVVILDEPTA
GVDPASRRGI WELLLKYREG RTLILSTHHL DEAELLGDRV AVVAGGRLCC CGSPLFLRRH
LGSGYYLTLV KARLPLTTNE KADTDMEGSV DTGQEKKNGS TPQLLALVQH WVPGARLVEE
LPHELVLVLP YTGAHDGSFA TLFRELDTRL AELRLTGYGI SDTSLEEIFL KVVEECAADT
DMEDGSCGQH LRTGIAGLDV TLRLKMPPEE TALENGEPAG LAPETHQGSG PDAVGRVQGW
ALTRQQLQAL LLKRFLLARR SRRGLFAQIV LPALFVGLAL VFSLIVPPFG HYPALRLSPT
MYGAQVSFFS EDAPGDPGRA RLLKALLEEA GLEEPPVQHS SHRFSAPEVP AEVAKVLASG
NWTPESPSPA CQCSRPGARR LLPDCPAAAG GPPPPQAVTG SGEVVQNLTG RNLSDFLVKT
YPRLVRQGLK TKKWVNEVRY GGFSLGGRDP GLPSGQELGR SVEELWALLT PLPGGTLDRV
LKNLTAWAHS LDAQDSLKIW FNNKGWHSMV AFVNRASNAI LRAHLPPGLA RHAHSITTLN
HPLNLTKEQL SEAALMASSV DVLVSICVVF AMSFVPASFT LVLIEERVTR AKHLQLMGGL
SPTLYWLGNF LWDMCNYLVP ACIVVLIFLA FQQRAYVAPA NLPALLLLLL LYGWSITPLM
YPASFFFSVP STAYVVLTCI NLFIGINGSM ATFVLELFSD QKLQEVSRIL KQVFLIFPHF
CLGRGLIDMV RNQAMADAFE RLGDRQFQSP LRWEVVGKNL LAMVIQGPLF LLFTLLLQHR
SQLLPQPRVR SLPLLGEEDE DVARERERVV QGATQGDVLV LRNLTKVYRG QRMPAVDRLC
LGIPPGECFG LLGVNGAGKT STFRMVTGDT LASRGEAVLA GHSVAREPSA AHLSMGYCPQ
SDAIFELLTG REHLELLARL RGVPEAQVAQ TAGSGLARLG LSLYADRPAG TYSGGNKRKL
ATAVALVGDP AVVFLDEPTT GMDPSARRFL WNSLLAVVRE GRSVMLTSHS MEECEALCSR
LAIMVNGRFR CLGSPQHLKG RFAAGHTLTL RVPAARSQPA AAFVAAQFPG AELREAHGGR
LRFQLPPGGR CALARVFGEL AVHGAEHGVE DFSVSQTMLE EVFLYFSKDQ GKDEDTEEQK
EAGVGVDPAP GLQHPKRISQ FLDDRSTAET VL
//
