ID G3R7N1_GORGO Unreviewed; 344 AA.
AC G3R7N1;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 64.
DE SubName: Full=Calcium homeostasis modulator 3 {ECO:0000313|Ensembl:ENSGGOP00000011371.2};
GN Name=CALHM3 {ECO:0000313|Ensembl:ENSGGOP00000011371.2};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000011371.2, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000011371.2, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000011371.2, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000011371.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the CALHM family.
CC {ECO:0000256|ARBA:ARBA00008497}.
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DR EMBL; CABD030075905; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_004050092.1; XM_004050044.2.
DR AlphaFoldDB; G3R7N1; -.
DR STRING; 9593.ENSGGOP00000011371; -.
DR Ensembl; ENSGGOT00000011703.3; ENSGGOP00000011371.2; ENSGGOG00000011662.3.
DR GeneID; 101142921; -.
DR KEGG; ggo:101142921; -.
DR CTD; 119395; -.
DR eggNOG; ENOG502QRUK; Eukaryota.
DR GeneTree; ENSGT01030000234610; -.
DR HOGENOM; CLU_069286_0_0_1; -.
DR InParanoid; G3R7N1; -.
DR OMA; RCWSQAL; -.
DR OrthoDB; 5296902at2759; -.
DR TreeFam; TF329085; -.
DR Proteomes; UP000001519; Chromosome 10.
DR Bgee; ENSGGOG00000011662; Expressed in frontal cortex and 2 other cell types or tissues.
DR GO; GO:0016323; C:basolateral plasma membrane; IEA:Ensembl.
DR GO; GO:0005261; F:monoatomic cation channel activity; IBA:GO_Central.
DR GO; GO:0005244; F:voltage-gated monoatomic ion channel activity; IEA:Ensembl.
DR GO; GO:0015867; P:ATP transport; IEA:Ensembl.
DR GO; GO:0051291; P:protein heterooligomerization; IEA:Ensembl.
DR GO; GO:0050909; P:sensory perception of taste; IEA:Ensembl.
DR InterPro; IPR029569; CALHM.
DR PANTHER; PTHR32261; CALCIUM HOMEOSTASIS MODULATOR PROTEIN; 1.
DR PANTHER; PTHR32261:SF7; CALCIUM HOMEOSTASIS MODULATOR PROTEIN 3; 1.
DR Pfam; PF14798; Ca_hom_mod; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 21..37
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 49..70
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 178..198
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 264..286
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 344 AA; 38496 MW; D4F6FFAB671E92E9 CRC64;
MDKFRMLFQH FQSSSESVMN GICLLLAAVT VKLYSSFDFN CPCLVHYNAL YGLGLLLMPP
LALFLCGLLA NRQSVVMVEE WRRPAGHRRK DPGIIRYMCS SVLQRALAAP LVWILLALLD
GKCFVCAFSS SVDPEKFLDF ANMTPSQVQL FLAKVPCKED ELVRDSPARK AVSRYLRCLS
QAIGWSVTLL LIIAAFLARC LRPCFDQTVF LQRRYWSNYV DLEQKLFDET CCEHARDFAH
RCVLHFFASM QSELQARGLR RDNAGRSLEP PAVPEPPEGL DSGSGKAHLR AISSRKQVDR
LLSTWYSSKP PLDLPASPGL CGGGLSHRAP TLALGTRLSQ HTDV
//
