ID G3R8T8_GORGO Unreviewed; 875 AA.
AC G3R8T8;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 69.
DE RecName: Full=Cadherin-2 {ECO:0000256|ARBA:ARBA00021703};
DE AltName: Full=Neural cadherin {ECO:0000256|ARBA:ARBA00031121};
GN Name=CDH2 {ECO:0000313|Ensembl:ENSGGOP00000011808.3};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000011808.3, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000011808.3, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000011808.3, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000011808.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Cadherins are calcium-dependent cell adhesion proteins.
CC {ECO:0000256|RuleBase:RU004357}.
CC -!- SUBCELLULAR LOCATION: Cell junction, adherens junction
CC {ECO:0000256|ARBA:ARBA00004536}. Cell membrane, sarcolemma
CC {ECO:0000256|ARBA:ARBA00004135}. Cell membrane
CC {ECO:0000256|ARBA:ARBA00004251, ECO:0000256|RuleBase:RU003318}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251,
CC ECO:0000256|RuleBase:RU003318}. Cell surface
CC {ECO:0000256|ARBA:ARBA00004241}. Membrane
CC {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479}.
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DR EMBL; CABD030108771; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030108772; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030108773; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030108774; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030108775; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030108776; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G3R8T8; -.
DR Ensembl; ENSGGOT00000012149.3; ENSGGOP00000011808.3; ENSGGOG00000012100.3.
DR GeneTree; ENSGT00940000155981; -.
DR Proteomes; UP000001519; Chromosome 18.
DR Bgee; ENSGGOG00000012100; Expressed in heart and 6 other cell types or tissues.
DR GO; GO:0005912; C:adherens junction; IEA:UniProtKB-SubCell.
DR GO; GO:0009986; C:cell surface; IEA:UniProtKB-SubCell.
DR GO; GO:0042383; C:sarcolemma; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR CDD; cd11304; Cadherin_repeat; 3.
DR Gene3D; 2.60.40.60; Cadherins; 6.
DR Gene3D; 4.10.900.10; TCF3-CBD (Catenin binding domain); 1.
DR InterPro; IPR039808; Cadherin.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR014868; Cadherin_pro_dom.
DR InterPro; IPR000233; Cadherin_Y-type_LIR.
DR InterPro; IPR027397; Catenin-bd_sf.
DR PANTHER; PTHR24027:SF79; CADHERIN-2; 1.
DR PANTHER; PTHR24027; CADHERIN-23; 1.
DR Pfam; PF01049; CADH_Y-type_LIR; 1.
DR Pfam; PF00028; Cadherin; 5.
DR Pfam; PF08758; Cadherin_pro; 1.
DR PRINTS; PR00205; CADHERIN.
DR PRINTS; PR01820; DESMOCOLLIN.
DR SMART; SM00112; CA; 5.
DR SMART; SM01055; Cadherin_pro; 1.
DR SUPFAM; SSF49313; Cadherin-like; 6.
DR PROSITE; PS00232; CADHERIN_1; 2.
DR PROSITE; PS50268; CADHERIN_2; 5.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW ProRule:PRU00043};
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003318};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003318};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 693..715
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 129..236
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 237..351
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 352..466
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 467..574
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 573..679
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT REGION 832..853
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 833..852
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 875 AA; 97036 MW; 6066EF1D962CB706 CRC64;
IFLLRRYVCI FTEKLKNQAE LYVFLSVKFS NCNGKRKVQY ESSEPADFKV DEDGMVYAVR
SFPLSSEHAK FLIYAQDKET QEKWQVAVKL SLKPTLTEES VKESAEVEEI VFPRQFSKHS
GHLQRQKRDW VIPPINLPEN SRGPFPQELV RIRSDRDKNL SLRYSVTGPG ADQPPTGIFI
INPISGQLSV TKPLDREQIA RFHLRAHAVD INGNQVENPI DIVINVIDMN DNRPEFLHQV
WNGTVPEGSK PGTYVMTVTA IDADDPNALN GMLRYRIVSQ APSTPSPNMF TINNETGDII
TVAAGLDREK VQQYTLIIQA TDMEGNPTYG LSNTATAIIT VTDVNDNPPE FTAMTFYGEV
PENRVDIIVA NLTVTDKDQP HTPAWNAVYR ISGGDPTGRF AIQTDPNSND GLVTVVKPID
FETNRMFVLT VAAENQVPLA KGIQHPPQST ATVSVTVIDV NENPYFAPNP KIIRQEEGLH
AGTMLTTFTA QDPDRYMQQN IRYTKLSDPA NWLKIDPVNG QITTIAVLDR ESPNVKNNIY
NATFLASDNG IPPMSGTGTL QIYLLDINDN APQVLPQEAE TCETPDPNSI NITALDYDID
PNAGPFAFDL PLSPVTIKRN WTITRLNGDF AQLNLKIKFL EAGIYEVPII ITDSGNPPKS
NISILRVKVC QCDSNGDCTD VDRIVGAGLG TGAIIAILLC IIILLILVLM FVVWMKRRDK
ERQAKQLLID PEDDVRDNIL KYDEEGGGEE DQDYDLSQLQ QPDTVEPDAI KPVGIRRMDE
RPIHAEPQYP VRSAAPHPGD IGDFINEGLK AADNDPTAPP YDSLLVFDYE GSGSTAGSLS
SLNSSSSGGE QDYDYLNDWG PRFKKLADMY GGGDD
//
