GenomeNet

Database: UniProt
Entry: G3RA81_GORGO
LinkDB: G3RA81_GORGO
Original site: G3RA81_GORGO 
ID   G3RA81_GORGO            Unreviewed;      4755 AA.
AC   G3RA81;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 2.
DT   28-MAR-2018, entry version 44.
DE   SubName: Full=Ryanodine receptor 2 {ECO:0000313|Ensembl:ENSGGOP00000012340};
GN   Name=RYR2 {ECO:0000313|Ensembl:ENSGGOP00000012340};
OS   Gorilla gorilla gorilla (Western lowland gorilla).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Gorilla.
OX   NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000012340, ECO:0000313|Proteomes:UP000001519};
RN   [1] {ECO:0000313|Ensembl:ENSGGOP00000012340, ECO:0000313|Proteomes:UP000001519}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Scally A.;
RT   "Insights into the evolution of the great apes provided by the gorilla
RT   genome.";
RL   Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSGGOP00000012340}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
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DR   EMBL; CABD030009618; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030009619; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030009620; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030009621; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030009622; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030009623; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030009624; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030009625; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030009626; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030009627; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSGGOT00000012697; ENSGGOP00000012340; ENSGGOG00000012582.
DR   GeneTree; ENSGT00760000119152; -.
DR   Proteomes; UP000001519; Chromosome 1.
DR   Bgee; ENSGGOG00000012582; -.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 2.
DR   Pfam; PF13833; EF-hand_8; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 2.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 2.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001519};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4068   4087       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4288   4308       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4362   4381       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4498   4519       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4556   4577       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4632   4655       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      111    166       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      173    218       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      226    281       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      287    344       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      352    409       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      600    810       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1026   1229       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     3811   3846       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   COILED      473    493       {ECO:0000256|SAM:Coils}.
FT   COILED     2872   2892       {ECO:0000256|SAM:Coils}.
FT   COILED     3137   3157       {ECO:0000256|SAM:Coils}.
FT   COILED     4200   4233       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   4755 AA;  540130 MW;  1DDFC7C76B7259FA CRC64;
     MIWTVQSCHV SLIFPSLSPP LQDDEVVLQC TATIHKEQQK LCLAAEGFGN RLCFLESTSN
     SKNVPPDLSI CTFVLEQSLS VRALQEMLAN TVEKSEGQVD VEKWTAQGGG HRTLLYGHAI
     LLRHSYSGMY LCCLSTSRSS TDKLAFDVGL QEDTTGEACW WTIHPASKQR SEGEKVRVGD
     DLILVSVSSE RYLHLSYGNG SLHVDAAFQQ TLWSVAPISS GSEAAQGYLI GGDVLRLLHG
     HMDECLTVPS GEHGEEQRRT VHYEGGAVSV HARSLWRLET LRVAWSGSHI RWGQPFRLRH
     VTTGKYLSLM EDKNLLLMDK EKADVKSTAF TFRSSKEKLD VGVRKEVDGM GTSEIKYGDS
     VCYIQHVDTG LWLTYQSVDV KSVRMGSIQR KAIMHHEGHM DDGISLSRSQ HEESRTARVI
     RSTVFLFNRF IRGLDALSKK AKASTVDLPI ESVSLSLQDL IGYFHPPDEH LEHEDKQNRL
     RALKNRQNLF QEEGMINLVL ECIDRLHVYS SAAHFADVAG REAGESWKSI LNSLYELLAA
     LIRGNRKNCA QFSGSLDWLI SRLERLEASS GILEVLHCVL VESPEALNII KEGHIKSIIS
     LLDKHGRNHK VLDVLCSLCV CHGVAVRSNQ HLICDNLLPG RDLLLQTRLV NHVSSMRPNI
     FLGVSEGSAQ YKKWYYELMV DHTEPFVTAE ATHLRVGWAS TEGYSPYPGG GEEWGGNGVG
     DDLFSYGFDG LHLWSGCIAR TVSSPNQHLL RTDDVISCCL DLSAPSISFR INGQPVQGMF
     ENFNIDGLFF PVVSFSAGIK VRFLLGGRHG EFKFLPPPGY APCYEAVLPK EKLKVEHSRE
     YKQERTYTRD LLGPTVSLTQ AAFTPIPVDT SQIVLPPHLE RIREKLAENI HELWVMNKIE
     LGWQYGPVRD DNKRQHPCLV EFSKLPEQER NYNLQMSLET LKTLLALGCH VGISDEHAED
     KVKKMKLPKN YQLTSGYKPA PMDLSFIKLT PSQEAMVDKL AENAHNVWAR DRIRQGWTYG
     IQQDVKNRRN PRLVPYTLLD DRTKKSNKDS LREAVRTLLG YGYNLEAPDQ DHAARAEVCS
     GTGERFRIFR AEKTYAVKAG RWYFEFETVT AGDMRVGWSR PGCQPDQELG SDERAFAFDG
     FKAQRWHQGN EHYGRSWQAG DVVGCMVDMN EHTMMFTLNG EILLDDSGSE LAFKDFDVGD
     GKSTMFCVFF KFATQLGLQI QVLFCLVLLC QYLVLLSSQY YYSVRIFPGQ EPANVWVGWI
     TSDFHQYDTG FDLDRVRTVT VTLGDEKGKV HESIKRSNCY MVCAGESMSP GQGRNNNGLE
     IGCVVDAASG LLTFIANGKE LSTYYQVEPS TKLFPAVFAQ ATSPNVFQFE LGRIKNVMPL
     SAGLFKSEHK NPVPQCPPRL HVQFLSHVLW SRMPNQFLKV DVSRISERQG WLVQCLDPLQ
     FMSLHIPEEN RSVDILELTE QEELLKFHYH TLRLYSAVCA LGNHRVAHAL CSHVDEPQLL
     YAIENKYMPG LLRAGYYDLL IDIHLSSYAT ARLMMNNEYI VPMTEETKSI TLFPDENKKH
     GLPGIGLSTS LRPRMQFSSP SFVSISNECY QYSPEFPLDI LKSKTIQMLT EAVKEGSLHA
     RDPVGGTTEF LFVPLIKLFY TLLIMGIFHN EDLKHILQLI EPSVFKEAAT PEEESDTLEK
     ELSVDDAKLQ GAGEEEAKGG KRPKEGLLQM KLPEPVKLQM CLLLQYLCDC QVRHRIEAIV
     AFSDDFVAKL QDNQRFRYNE VMQALNMSAA LTARKTKEFR SPPQEQINML LNFKDDKSEC
     PCPEEIRDQL LDFHEDLMTH CGIELDEDGS LDGNSDLTIR GRLLSLVEKV TYLKKKQAEK
     PVESDSKKSS TLQQLISETM VRWAQESVIE DPELVRAMFV LLHRQYDGIG GLVRALPKTY
     TINGVSVEDT INLLASLGQI RSLLSVRMGK EEEKLMIRGL GDIMNNKVFY QHPNLMRALG
     MHETVMEVMV NVLGGGESKE ITFPKMVANC CRFLCYFCRI SRQNQKAMFD HLSYLLENSS
     VGLASPAMRG STPLDVAAAS VMDNNELALA LREPDLEKVV RYLAGCGLQS CQMLVSKGYP
     DIGWNPVEGE RYLDFLRFAV FCNGESVEEN ANVVVRLLIR RPECFGPALR GEGGNGLLAA
     MEEAIKIAED PSRDGPSPNS GSSKTLDTEE EEDDTIHMGN AIMTFYSALI DLLGRCAPEM
     HLIHAGKGEA IRIRSILRSL IPLGDLVGVI SIAFQMPTIA KDGNVVEPDM SAGFCPDHKA
     AMVLFLDRVY GIEVQDFLLH LLEVGFLPDL RAAASLDTAA LSATDMALAL NRYLCTAVLP
     LLTRCAPLFA GTEHHASLID SLLHTVYRLS KGCSLTKAQR DSIEVCLLSI CGQLRPSMMQ
     HLLRRLVFDV PLLNEHAKMP LKLLTNHYER CWKYYCLPGG WGNFGAASEE ELHLSRKLFW
     GIFDALSQKK YEQELFKLAL PCLSAVAGAL PPDYMESNYV SMMEKQSSMD SEGNFNPQPV
     DTSNITIPEK LEYFINKYAE HSHDKWSMDK LANGWIYGEI YSDSSKVQPL MKPYKLLSEK
     EKEIYRWPIK ESLKTMLAWG WRIERTREGD SMALYNRTRR ISQTSQVSVD AAHGYSPRAI
     DMSNVTLSRD LHAMAEMMAE NYHNIWAKKK KMELESKGGG NHPLLVPYDT LTAKEKAKDR
     EKAQDILKFL QINGYAVSRG FKDLELDTPS IEKRFAYSFL QQLIRYVDEA HQYILEFDGG
     SRGKGEHFPY EQEIKFFAKV VLPLIDQYFK NHRLYFLSAA SRPLCSGGHA SNKEKEMVTS
     LFCKLGVLVR HRISLFGNDA TSIVNCLHIL GQTLDARTVM KTGLESVKSA LRAFLDNAAE
     DLEKTMENLK QGQFTHTRNQ PKGVTQIINY TTVALLPMLS SLFEHIGQHQ FGEDLILEDV
     QVSCYRILTS LYALGTSKSI YVERQRSALG ECLAAFAGAF PVAFLETHLD KHNIYSIYNT
     KSSRERAALS LPTNVEDVCP NIPSLEKLME EIVELAESGI RYTQMPHVME VILPMLCSYM
     SRWWEHGPEN NPERAEMCCT ALNSEHMNTL LGNILKIIYN NLGIDEGAWM KRLAVFSQPI
     INKVKPQLLK THFLPLMEKL KKKAATVVSE EDHLKAEARG DMSEAELLIL DEFTTLKYLY
     PFLIILIYQI NTYLCKNLQV LLVLTEISFA TSQNFKREEQ NFVVQNEINN MSFLITDTKS
     KMSKAAVSDQ ERKKMKRKGD RYSMQTSLIV AALKRLLPIG LNICAPGDQE LIALAKNRFS
     LKDTEDEVRD IIRSNIHLQG KLEDPAIRWQ MALYKDLPNR TDDTSDPEKT VERVLDIANV
     LFHLEQKSKR VGRRHYCLGS TVEHPQRSKK AVWHKLLSKQ RKRAVVACFR MAPLYNLPRH
     RAVNLFLQGY EKSWIETEEH YFEDKLIEDL AKPGAEPPEE DEGTKRVDPL HQLILLFSRT
     ALTEKCKLEE DFLYMAYADI MAKEKEMEKQ KLLYQQARLH DRGAAEMVLQ TISASKGETG
     PMVAATLKLG IAILNGGNST VQQKMLDYLK EKKDVGFFQS LAGLMQSCSV LDLNAFERQN
     KAEGLGMVTE EGSGEKVLQD DEFTCDLFRF LQLLCEGHNS DFQNYLRTQT GNNTTVNIII
     STVDYLLRVQ ESISDFYWYY SGKDVIDEQG QRNFSKAIQV AKQVFNTLTE YIQGPCTGNQ
     QSLAHSRLWD AVVGFLHVFA HMQMKLSQDS SQIELLKELM DLQKDMVVML LSMLEGNVVN
     GTIGKQMVDM LVESSNNVEM ILKFFDMFLK LKDLTSSDTF KEYDPDGKGV ISKRDFHKAM
     ESHKHYTQSE TEFLLSCAET DENETLDYEE FVKRFHEPAK DIGFNVAVLL TNLSEHMPND
     TRLQTFLELA ESVLNYFQPF LGRIEIMGSA KRIERVYFEI SESSRTQWEK PQVKESKRQF
     IFDVVNEGGE KEKMELFVNF CEDTIFEMQL AAQISESDLN ERSANKEESE KERPEEQGPR
     MAFFSILTVK SALFALRYNI LTLMRMLSLK SLKKQMKKVK KMTVKDMVTA FFSSYWSIFM
     TLLHFVASVF RGFFRIICSL LLGGSLVEGA KKIKVAELLA NMPDPTQDEV RGDGEEGERK
     PLEAALPSED LTDLKELTEE SDLLSDIFGL DLKREGGQYK LIPHNPNAGL SDLMSNPVPM
     PEVQEKFQEQ KAKEEEKEEK EETKSEPEKA EGEDGEKEEK AKEDKGKQKL RQLHTHRYGE
     PEVPESAFWK KIIAYQQKLL NYFARNFYNM RMLALFVAFA INFILLFYKV STSSVVEGKE
     LPTRSSSENA KVTSLDSSSH RIIAVHYVLE ESSGYMEPTL RILAILHTVI SFFCIIGYYC
     LKVPLVIFKR EKEVARKLEF DGLYITEQPS EDDIKGQWDR LVINTQSFPN NYWDKFVKRK
     VMDKYGEFYG RDRISELLGM DKAALDFSDA REKKKPKKDS SLSAVLNSID VKYQMWKLGV
     VFTDNSFLYL AWYMTMSVLG HYNNFFFAAH LLDIAMGFKT LRTILSSVTH NGKQLVLTVG
     LLAVVVYLYT VVAFNFFRKF YNKSEDGDTP DMKCDDMLTC YMFHMYVGVR AGGGIGDEIE
     DPAGDEYEIY RIIFDITFFF FVIVILLAII QGLIIDAFGE LRDQQEQVKE DMETKCFICG
     IGNDYFDTVP HGFETHTLQE HNLANYLFFL MYLINKDETE HTGQESYVWK MYQERCWEFF
     PAGDCFRKQY EDQLN
//
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