ID   G3RAF8_GORGO            Unreviewed;       843 AA.
AC   G3RAF8;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 2.
DT   27-MAR-2024, entry version 59.
DE   RecName: Full=Tetratricopeptide repeat protein 27 {ECO:0000256|ARBA:ARBA00024124};
GN   Name=TTC27 {ECO:0000313|Ensembl:ENSGGOP00000012429.3};
OS   Gorilla gorilla gorilla (Western lowland gorilla).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Gorilla.
OX   NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000012429.3, ECO:0000313|Proteomes:UP000001519};
RN   [1] {ECO:0000313|Ensembl:ENSGGOP00000012429.3, ECO:0000313|Proteomes:UP000001519}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Scally A.;
RT   "Insights into the evolution of the great apes provided by the gorilla
RT   genome.";
RL   Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSGGOP00000012429.3, ECO:0000313|Proteomes:UP000001519}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=22398555; DOI=10.1038/nature10842;
RA   Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA   Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA   McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA   Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA   Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA   Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA   Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA   Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA   Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA   Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA   Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA   Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA   Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT   "Insights into hominid evolution from the gorilla genome sequence.";
RL   Nature 483:169-175(2012).
RN   [3] {ECO:0000313|Ensembl:ENSGGOP00000012429.3}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the TTC27 family.
CC       {ECO:0000256|ARBA:ARBA00024020}.
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DR   EMBL; CABD030013538; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030013539; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030013540; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030013541; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030013542; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030013543; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_004029129.1; XM_004029080.1.
DR   AlphaFoldDB; G3RAF8; -.
DR   STRING; 9593.ENSGGOP00000012429; -.
DR   Ensembl; ENSGGOT00000012789.3; ENSGGOP00000012429.3; ENSGGOG00000012734.3.
DR   GeneID; 101143902; -.
DR   KEGG; ggo:101143902; -.
DR   CTD; 55622; -.
DR   eggNOG; KOG1128; Eukaryota.
DR   GeneTree; ENSGT00500000044929; -.
DR   HOGENOM; CLU_004905_2_0_1; -.
DR   InParanoid; G3RAF8; -.
DR   OMA; NNRYARA; -.
DR   OrthoDB; 23605at2759; -.
DR   TreeFam; TF105894; -.
DR   Proteomes; UP000001519; Chromosome 2A.
DR   Bgee; ENSGGOG00000012734; Expressed in testis and 6 other cell types or tissues.
DR   Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR013105; TPR_2.
DR   InterPro; IPR019734; TPR_repeat.
DR   InterPro; IPR044244; TTC27/Emw1.
DR   PANTHER; PTHR16193:SF0; TETRATRICOPEPTIDE REPEAT PROTEIN 27; 1.
DR   PANTHER; PTHR16193; UNCHARACTERIZED; 1.
DR   Pfam; PF07719; TPR_2; 1.
DR   SMART; SM00028; TPR; 4.
DR   SUPFAM; SSF48452; TPR-like; 1.
DR   PROSITE; PS50005; TPR; 2.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW   TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339}.
FT   REPEAT          527..560
FT                   /note="TPR"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT   REPEAT          561..594
FT                   /note="TPR"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
SQ   SEQUENCE   843 AA;  96720 MW;  93EBE6A26C82FFD5 CRC64;
     MWTPELAILR GFPTEAERQQ WKQEGVVGSE SGSFLQLLLE GNYEAIFLNS MTQNIFNSTT
     TTEEKIDSYL EKQVVTFLDY STDLDTTERQ QLIFLLGVSS LQLFVQSNWT GPPVDLHPQD
     FLSSVLFQQF SEVKGLDAFV LSLLTLDGES IYSLTSKPIL LLLARIILVN VRHKLTAIQS
     LPWWTLRCVN IHQHLLEERS PLLFTLAENC IDQVMKLQNL FVDDSGRYLA IQFHLECAYV
     FLYYYEYRKA KDQLDIAKDI SQLQIDLTGA LGKRTRFQEN YVAQLILDVR REGDVLSNCE
     FTPAPTPQEH LTKNLELNDD TILNDIKLAD CEQFQMPDLC AEEIAIILGI CTNFQKNNPV
     HTLTEEELLA FTSCLLSQPK FWAIQTSALI LRTKLEKGST RRVERAMRQT QALADQFEDK
     TTSVLERLKI FYCCQVPPHW AIQRQLASLL FELGCTSSAL QIFEKLEMWE DVVICYERAG
     QHGKAEEILR QELEKKETPS LYCLLGDVLG DHSCYDKAWE LSRYRSARAQ RSKALLHLRN
     KEFQECVECF ERSVKINPMQ LGVWFSLGCA YLALEDYQGS AKAFQRCVTL EPDNAEAWNN
     LSTSYIRLKQ KVKAFRTLQE ALKCNYEHWQ IWENYILTST DVGEFSEAIK AYHRLLDLRD
     KYKDVQVLKI LVRAVIDGMT DRSGDVATGL KGKLQELFGR VTSRVTNDGE IWRLYAHVYG
     NGQSEKPDEN EKAFQCLSKA YKCDTQSSCW EKDITSFKEV VQRALGLAHV AIKCSKNKTS
     PQETVQMLSS VRLNLRGLLS KAKQLFTDVA TGEMSRELAD DITAMDTLVT ELQDLSNQFR
     NQY
//