ID G3RB20_GORGO Unreviewed; 2096 AA.
AC G3RB20;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=Tudor domain containing 6 {ECO:0000313|Ensembl:ENSGGOP00000012656.2};
GN Name=TDRD6 {ECO:0000313|Ensembl:ENSGGOP00000012656.2};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000012656.2, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000012656.2, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000012656.2, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000012656.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; CABD030044895; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030044896; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_004044186.1; XM_004044138.1.
DR STRING; 9593.ENSGGOP00000012656; -.
DR Ensembl; ENSGGOT00000013021.3; ENSGGOP00000012656.2; ENSGGOG00000012971.3.
DR GeneID; 101153364; -.
DR KEGG; ggo:101153364; -.
DR CTD; 221400; -.
DR eggNOG; KOG2039; Eukaryota.
DR GeneTree; ENSGT00940000159049; -.
DR HOGENOM; CLU_001126_1_0_1; -.
DR InParanoid; G3RB20; -.
DR OMA; VDYGQTK; -.
DR OrthoDB; 4266629at2759; -.
DR Proteomes; UP000001519; Chromosome 6.
DR Bgee; ENSGGOG00000012971; Expressed in testis and 1 other cell type or tissue.
DR GO; GO:0043186; C:P granule; IBA:GO_Central.
DR GO; GO:0030719; P:P granule organization; IBA:GO_Central.
DR GO; GO:0034587; P:piRNA processing; IBA:GO_Central.
DR GO; GO:0007283; P:spermatogenesis; IBA:GO_Central.
DR CDD; cd20420; Tudor_TDRD6_rpt1; 1.
DR CDD; cd20421; Tudor_TDRD6_rpt2; 1.
DR CDD; cd20422; Tudor_TDRD6_rpt3; 1.
DR CDD; cd20425; Tudor_TDRD6_rpt6; 1.
DR CDD; cd20426; Tudor_TDRD6_rpt7; 1.
DR Gene3D; 2.30.30.140; -; 6.
DR Gene3D; 2.40.50.90; -; 7.
DR InterPro; IPR035437; SNase_OB-fold_sf.
DR InterPro; IPR002999; Tudor.
DR InterPro; IPR047444; Tudor_TDRD6_rpt1.
DR InterPro; IPR047445; Tudor_TDRD6_rpt2.
DR InterPro; IPR047447; Tudor_TDRD6_rpt3.
DR PANTHER; PTHR22948; TUDOR DOMAIN CONTAINING PROTEIN; 1.
DR PANTHER; PTHR22948:SF29; TUDOR DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF00567; TUDOR; 7.
DR SMART; SM00333; TUDOR; 8.
DR SUPFAM; SSF63748; Tudor/PWWP/MBT; 7.
DR PROSITE; PS50304; TUDOR; 6.
PE 4: Predicted;
KW Differentiation {ECO:0000256|ARBA:ARBA00022871};
KW Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW Spermatogenesis {ECO:0000256|ARBA:ARBA00022871}.
FT DOMAIN 309..368
FT /note="Tudor"
FT /evidence="ECO:0000259|PROSITE:PS50304"
FT DOMAIN 535..592
FT /note="Tudor"
FT /evidence="ECO:0000259|PROSITE:PS50304"
FT DOMAIN 815..874
FT /note="Tudor"
FT /evidence="ECO:0000259|PROSITE:PS50304"
FT DOMAIN 1032..1087
FT /note="Tudor"
FT /evidence="ECO:0000259|PROSITE:PS50304"
FT DOMAIN 1351..1410
FT /note="Tudor"
FT /evidence="ECO:0000259|PROSITE:PS50304"
FT DOMAIN 1566..1625
FT /note="Tudor"
FT /evidence="ECO:0000259|PROSITE:PS50304"
FT REGION 286..315
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 447..470
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 448..470
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2096 AA; 236280 MW; AB22B046291FFD80 CRC64;
MCSTPGMPAP GASLALRVSF VDVHPDVIPV QLWGLVGERR GEYLRLSREI QEAAATRGQW
ALGSASASPG ELCLVQVGLL WHRCRVVSRQ AQESRVFLLD EGRTITAGAG SLAPGRREFF
NLPSEVLGCV LAGLVPAGCG AGAGEPQHWP ADAVDFLSNL QGKEVHGCVL DVLLLHRLVL
LEVPDVFQQM RELGLARRVP DSLFRSLLER YLTAATASVG SGVPVLSRVP LKQKQPGLDY
FYPQLQLGVT EAVVITQVCH PHRIHCQLRS LSQEIHRLSE SMAQVYRGST GTGDENSTSA
TWEEREESPD KPGSPCASCG LDGHWYRALL LETFRPQRCA QVLHVDYGRK ELVSCSSLRY
LLPEYFRMPV VTYPCALYGL WDGGRGWSRS QVGDLKALIL GKAVNAKIEF YCSFEHVYYV
SLYGEDGINL NRVFGVQSCC LADRVLQSQG TEEEEPETSQ SRSPAEEVDE EISLPALRSI
RLKMNAFYDA QVEFVKNPSE FWIRLRKHNV TFSKLMRRMC GFYSSASKLD GVVLKPEPDD
LCCVKWKENG YYRAIVTKLD DKSVDVFLVD RGNSENVDWY DVRMLLPQFR QLPILAVKCT
LADIWPLGKT WSQEAVSFFK KTVLHKELVI HILDKQDHQY VIEILDESRT GEENISKVIA
QAGYAKYQEF EIKENILVNA HSPGHVSNHF TTESNKIPFA KTGEGEQKAK RENKTTSVSK
ALSDTTVVTN GSTELVVQEK VERASVYFPL IQNRLEIKPG SSSKGELEVG STVEVRVSYV
ENPGYFWCQL TRNIQGLKTL MSDIQYYCKN TAAPYQGNTL ACLAKRTVNR QWSRALISGI
PSVEHVNVTF VDYGDREMVS EKNIYSISEE FLKVKAQAFR CSLYNLIQPI GQNPFVWDVK
AIQAFNEFID NAWQKNLELK CTIFALASIN NELFNIVDLL TPFQSACHFL VEKRLARPVK
LQKPLESSVQ LHSYFYSTHD MKIGSEELVY VTHIDDPWTF YCQLARNANI LEQLSCSITQ
LSKVSLNLKT SPLNPGTLCL ARYADGNWYR GIVIEKEPKK VFFVDFGNIY VVTSDDLLPI
PSDAYDVLLL PMQAVRCSLS DIPDHIPEEV VVWFQETILD KSLKALVVAK DPDGTLIIEL
YGDNIQISAS INKKLGLLSY KDRIRKKESE VLRSTTETLE EKNENMKLPC TEYLSKSVGN
KLPNKEILEE SDKPQINSSY KELKLLQSLT KTNLVTQYQD SVGNKNSQVF PLTTEKKEEI
SAETPLKTAR VEATLSERKI GDSCDKDLPL KFCEFPQKTI MPGFKTTVYV SHINDLSDFY
VQLIEDEAEI SHLSERLNSV KTRPEYYAGP PLQRGDMICA VFPEDNLWYR AVIKEQQPND
LLSVQFIDYG NVSVVHTDKI GRLDLVNAIL PGLCIHCSLE GFGVPDNKNS KKMIHYFSQR
TSEAAIRCEF VKFQDRWEVI LADEHGIIAD VMISRYALSE KSQVELSTQV TKSASSKSVN
KSDIDTSVFL NWYNPEKKMI RAYATVIDGP EYFWCQFADT EKLQCLEVEV QTAGEQEADR
RNCIPCPYIG DPCIVRYRED GHYYRALITN ICEDYLVSVR LVDFGNIEDC VDPKALWAIP
SELLSVPMQA FPCCLSGFNI SEGLCSQEGN DYFYEIITED VLEITILEIR RDVCDIPLAI
VDLKSKGKSI NEKMEKYSKT GIIKSALPYE NIDSEVKQAL GSYNLDVGLK KLSNKAVQNK
IYMEQQTDEL AEITEKDVNI IGTKPSNFRD PKTDNICEGF ENPCKDKIDT EELEGELECH
LVDKAEFDDK YLITGFNTLL PHANETKEIL ELNSLEVPLS PDDESKEFLE LESIELQNSL
VVDEEKGELS PVPQNVPLSQ ECVTKGAMEL FTLQLPLSCE AEKQPELELP TAQLPLDDKM
DPLSLGVSQK AQESMCTEDM RKSSCVESFD DQRRMSLHLH GADCDPKTQN EMNIYEEEFV
EYKNRDAISA LMPLFSEEES SDGSKHNNGL PDHISAQLQN TYTLKAFTVG SKCVVWSSLT
NTWSKCEILE TAEEGTRVLN LSNGMEEIVN PENVWNGIPK LDKSPPEKRG LEVMEI
//
