ID G3RCR6_GORGO Unreviewed; 643 AA.
AC G3RCR6;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=Extracellular matrix protein 2 {ECO:0000313|Ensembl:ENSGGOP00000013300.3};
GN Name=ECM2 {ECO:0000313|Ensembl:ENSGGOP00000013300.3};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000013300.3, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000013300.3, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000013300.3, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000013300.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; CABD030065046; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030065047; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_018888889.1; XM_019033344.1.
DR AlphaFoldDB; G3RCR6; -.
DR Ensembl; ENSGGOT00000013681.3; ENSGGOP00000013300.3; ENSGGOG00000013631.3.
DR GeneID; 101148828; -.
DR CTD; 1842; -.
DR eggNOG; KOG0619; Eukaryota.
DR GeneTree; ENSGT00940000159941; -.
DR OrthoDB; 5361311at2759; -.
DR TreeFam; TF330031; -.
DR Proteomes; UP000001519; Chromosome 9.
DR Bgee; ENSGGOG00000013631; Expressed in heart and 6 other cell types or tissues.
DR Gene3D; 6.20.200.20; -; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR InterPro; IPR043184; ECM2.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR025875; Leu-rich_rpt_4.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR001007; VWF_dom.
DR PANTHER; PTHR46544:SF1; EXTRACELLULAR MATRIX PROTEIN 2; 1.
DR PANTHER; PTHR46544; EXTRACELLULAR MATRIX PROTEIN 2-RELATED; 1.
DR Pfam; PF12799; LRR_4; 1.
DR Pfam; PF13855; LRR_8; 2.
DR Pfam; PF00093; VWC; 1.
DR SMART; SM00364; LRR_BAC; 4.
DR SMART; SM00369; LRR_TYP; 11.
DR SMART; SM00214; VWC; 1.
DR SUPFAM; SSF57603; FnI-like domain; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR PROSITE; PS51450; LRR; 3.
DR PROSITE; PS01208; VWFC_1; 1.
DR PROSITE; PS50184; VWFC_2; 1.
PE 4: Predicted;
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..643
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014149349"
FT DOMAIN 101..158
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT REGION 187..292
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 187..210
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 222..247
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 248..270
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 643 AA; 73203 MW; 8C640B5C18C14836 CRC64;
MKIAVLFCFF LLIIFQTDFG QNEEIPRKQR RKIYHRRLRK SSASHKHRSN RQLGIPQTTV
FTPVARLPIV NFDYSMEEKF ESFSSFPGVE SSYNVLPGKK GHCLVKGITM YNKAVWSPEP
CTTCLCSDGR VLCDETMCHP QRCPQTVIPE GECCPVCSAT EQREPTNLLH KQLPPPQVGM
DQIVRKEALQ SKEDEEVKEE DTEQKRETPE SRNQGQLYSE GDSRGGDRKQ RPGEERRLAH
QQQRQGREEE EDEEEEGEEG EEDEEDEEDP VRGDMFRMPS RSPLPAPPRG TLRLPSGCSL
SYRTISCINA MLTQIPPLTA PQITSLELTG NSIASIPDEA FNGLPNLERL DLSKNNITSS
GIGPKAFKLL KKLMRLNMDG NNLIQIPSQL PSTLEELKIN ENNLQAIDEE SLSDLNQLVT
LELEGNNLSE ANVNPLAFKP LKSLAYLRLG KNKFRIIPQG LPGSIEELYL ENNQIEEITE
ICFNHTRKIN VIVLRYNKIE ENRIAPLAWI NQENLESIDL SYNKLYHVPS YLPKSLLHLV
LLGNQIERIP GYVFGHMEPG LEYLYLSFNK LADDGMDRVS FYGAYHSLRE LFLDHNDLKS
IPPGIQEMKA LHFLRLNNNK ISCVSDAVLE TVTNRSDVAF PLW
//
