ID G3RCY4_GORGO Unreviewed; 1271 AA.
AC G3RCY4;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 24-JAN-2024, entry version 47.
DE SubName: Full=EvC ciliary complex subunit 2 {ECO:0000313|Ensembl:ENSGGOP00000013374.3};
GN Name=EVC2 {ECO:0000313|Ensembl:ENSGGOP00000013374.3};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000013374.3, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000013374.3, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000013374.3, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000013374.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, cilium membrane
CC {ECO:0000256|ARBA:ARBA00004309}. Membrane
CC {ECO:0000256|ARBA:ARBA00004370}.
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DR EMBL; CABD030027005; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030027006; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030027007; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030027008; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030027009; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030027010; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G3RCY4; -.
DR Ensembl; ENSGGOT00000013760.3; ENSGGOP00000013374.3; ENSGGOG00000013705.3.
DR GeneTree; ENSGT00940000154127; -.
DR HOGENOM; CLU_007621_0_0_1; -.
DR Proteomes; UP000001519; Chromosome 4.
DR Bgee; ENSGGOG00000013705; Expressed in adult mammalian kidney and 5 other cell types or tissues.
DR GO; GO:0060170; C:ciliary membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-KW.
DR GO; GO:0007224; P:smoothened signaling pathway; IEA:InterPro.
DR InterPro; IPR022076; Limbin.
DR InterPro; IPR026501; Limbin/EVC.
DR PANTHER; PTHR16795:SF14; LIMBIN; 1.
DR PANTHER; PTHR16795; LIMBIN/ELLIS-VAN CREVELD PROTEIN; 1.
DR Pfam; PF12297; EVC2_like; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 262..284
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 1..39
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 747..779
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 426..453
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 970..1004
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1271 AA; 144399 MW; A5AE54814526FC41 CRC64;
RWRPLGAQPP RDPQVAPRSG PGLRTPPGRS GAGPESSTQD LPCMIWPKVE CCHFKTAVEA
PLGMKLDKKM EVFIPLSTSA ASSGPWAHSL FAFIPSWPKK NLFKRESPIT HHLYGDISRE
VRGTSENGVI FQKCALVSGS SEAQTARIWL LVNNTKTTSS ANLSELLLLD SIAGLTIWDS
IGNRTSEGFQ AFSKKFLQVG DAFAVSYAAT LQAGDLGNGE SLKLPAQLTF QSSSRNRTQL
KALFSITAEE NITVLPHHSL HAAGFFIAFL LSLVLTWAAL FLMVRYQCLK GNMLTRHRVW
QYESKLEPLP FTSADGVNED LSLNDQMIDI LSSEDPGSML QALEELEIAT LNRADADLEA
CRTQISKDII ALLLKNLTSS GHLSLQVERK MSAVFKKQFL LLENEIQEEY DRKMVALTAE
CDLETRKKME NQYQREMMAM EEAEELLKRA SERSAVECSN LLRTLHGLEQ EHLRKSLALQ
QEEDFAKAHR QLAVFQRNEL RSIFFTQIKS AIFKGELKPE AAKMLLQNYS KIQENVEELM
DFFQASKRYH LSKRFGHREY LVQNLQSSET RVQGLLSTAA AQLTHLIQKH ERAGYLDEDQ
MEMLLERAQT EVFSIKQKLD NDLKQEKKKL HQKLITKRRQ ELLQKHREQR REQVSIGEAF
QAVEDAGQYL HQRRSLMEEH GAALEELQER LDQAALDDLR TLTLSLFEKA TDELRRLQNS
AMTQELLKRG VPWLFLQQIL EEHGKEMAAR AEQLEGEERD RDQEGVQSVR QRLKDDAPEA
VTEEQAELRR WEHLIFMKLC SSVFSLSEEE LLRMRQEVHG CFAQMDRSLA LPKIRARVLL
QQFQTAWREA EFVKLDQAVA APELQQQSKV RKSRSKSKSK GELLKKCIED KIHLCEEQAS
EDLVEKVRGE LLRERVQRME AQEGGFAQSL VALQFQKASR VTETLSAYTA LLSIQDLLLE
ELSASEMLTK SACTQILESH SRELQELERK LEDQLMQQEA AQQQQALASW QQWVADGPGI
LNEPGEVDSE RQVSTALQQA LSKSQTLLEQ HQQCLREEQQ NSVVLEDLLE NMEADTFATL
CSQELKLASY LARMAMVPGA TLRRLLSVVL PTASQPQLLA LLDSATERHA DHAAESDGGV
EQVDVGRRRK HQSWWQALDG KLRGDLISRG LEKMLWARKR KQSILKKTCL PLRERMIFSG
KGSWPHLSLE PIGELAPVPI VGAETIDLLN TGEKLFIFRN PKEPEISLHV PPRKKKNFLN
AKKAMRALGM D
//