ID G3RD10_GORGO Unreviewed; 251 AA.
AC G3RD10;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=BTG anti-proliferation factor 4 {ECO:0000313|Ensembl:ENSGGOP00000013402.3};
GN Name=BTG4 {ECO:0000313|Ensembl:ENSGGOP00000013402.3};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000013402.3, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000013402.3, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000013402.3, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000013402.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the BTG family. {ECO:0000256|ARBA:ARBA00007989}.
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DR EMBL; CABD030081558; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030081559; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030081560; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G3RD10; -.
DR STRING; 9593.ENSGGOP00000013402; -.
DR Ensembl; ENSGGOT00000013788.3; ENSGGOP00000013402.3; ENSGGOG00000013742.3.
DR eggNOG; KOG4006; Eukaryota.
DR GeneTree; ENSGT00950000182952; -.
DR HOGENOM; CLU_079660_3_0_1; -.
DR InParanoid; G3RD10; -.
DR OMA; YLHRKTY; -.
DR TreeFam; TF105272; -.
DR Proteomes; UP000001519; Chromosome 11.
DR Bgee; ENSGGOG00000013742; Expressed in testis and 3 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003730; F:mRNA 3'-UTR binding; IEA:Ensembl.
DR GO; GO:0160021; P:maternal-to-zygotic transition of gene expression; IEA:Ensembl.
DR GO; GO:0008285; P:negative regulation of cell population proliferation; IBA:GO_Central.
DR GO; GO:0045930; P:negative regulation of mitotic cell cycle; IBA:GO_Central.
DR Gene3D; 3.90.640.90; Anti-proliferative protein, N-terminal domain; 1.
DR InterPro; IPR002087; Anti_prolifrtn.
DR InterPro; IPR033332; BTG.
DR InterPro; IPR036054; BTG-like_sf.
DR PANTHER; PTHR22978; B-CELL TRANSLOCATION GENE; 1.
DR PANTHER; PTHR22978:SF5; PROTEIN BTG4; 1.
DR Pfam; PF07742; BTG; 1.
DR PRINTS; PR00310; ANTIPRLFBTG1.
DR SMART; SM00099; btg1; 1.
DR SUPFAM; SSF160696; BTG domain-like; 1.
DR PROSITE; PS00960; BTG_1; 1.
DR PROSITE; PS01203; BTG_2; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000001519}.
FT DOMAIN 42..62
FT /note="Anti-proliferative protein"
FT /evidence="ECO:0000259|PROSITE:PS00960"
FT DOMAIN 88..107
FT /note="Anti-proliferative protein"
FT /evidence="ECO:0000259|PROSITE:PS01203"
FT REGION 224..251
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 251 AA; 29056 MW; 5D1D25E48B8875F6 CRC64;
MRDEIATTVF FVTRLVKKHD KLSKQQIEDF AEKLMTILFE TYRSHWHSDC PSKGQAFRCI
RINNNQNKDP ILERACVESN VDFSHLGLPK EMTIWVDPFE VCCRYGEKNH PFTVASFKGR
WEEWELYQQI SYAVSRASSE VFSGTSCDEE SCSKEPRVIP KVSNPKSIYQ VENLKQPFQS
WLQIPRKKNV VDGRVGLLGN TYHGSQKHPK CYRPAMHRMD RDYSHQGQQA RGHPAHLGNS
RVILDRHGSS G
//
