ID G3RDR4_GORGO Unreviewed; 559 AA.
AC G3RDR4;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 73.
DE SubName: Full=DEAF1 transcription factor {ECO:0000313|Ensembl:ENSGGOP00000013674.3};
GN Name=DEAF1 {ECO:0000313|Ensembl:ENSGGOP00000013674.3};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000013674.3, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000013674.3, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000013674.3, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000013674.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; CABD030077013; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030077014; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030077015; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030077016; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030077017; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030077018; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030077019; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030077020; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030077021; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030077022; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G3RDR4; -.
DR STRING; 9593.ENSGGOP00000013674; -.
DR Ensembl; ENSGGOT00000014068.3; ENSGGOP00000013674.3; ENSGGOG00000014020.3.
DR eggNOG; KOG4333; Eukaryota.
DR GeneTree; ENSGT00940000159701; -.
DR HOGENOM; CLU_039056_1_0_1; -.
DR InParanoid; G3RDR4; -.
DR OMA; KDHQHSC; -.
DR TreeFam; TF325664; -.
DR Proteomes; UP000001519; Chromosome 11.
DR Bgee; ENSGGOG00000014020; Expressed in prefrontal cortex and 5 other cell types or tissues.
DR GO; GO:0001650; C:fibrillar center; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IEA:Ensembl.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IEA:Ensembl.
DR GO; GO:0045893; P:positive regulation of DNA-templated transcription; IEA:Ensembl.
DR GO; GO:0033599; P:regulation of mammary gland epithelial cell proliferation; IEA:Ensembl.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 6.10.140.2220; -; 1.
DR Gene3D; 3.10.390.10; SAND domain-like; 1.
DR InterPro; IPR010919; SAND-like_dom_sf.
DR InterPro; IPR000770; SAND_dom.
DR InterPro; IPR002893; Znf_MYND.
DR PANTHER; PTHR10237:SF13; DEFORMED EPIDERMAL AUTOREGULATORY FACTOR 1 HOMOLOG; 1.
DR PANTHER; PTHR10237; DEFORMED EPIDERMAL AUTOREGULATORY FACTOR 1 HOMOLOG SUPPRESSIN; 1.
DR Pfam; PF01342; SAND; 1.
DR Pfam; PF01753; zf-MYND; 1.
DR SMART; SM00258; SAND; 1.
DR SUPFAM; SSF144232; HIT/MYND zinc finger-like; 1.
DR SUPFAM; SSF63763; SAND domain-like; 1.
DR PROSITE; PS50864; SAND; 1.
DR PROSITE; PS01360; ZF_MYND_1; 1.
DR PROSITE; PS50865; ZF_MYND_2; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00134}.
FT DOMAIN 187..267
FT /note="SAND"
FT /evidence="ECO:0000259|PROSITE:PS50864"
FT DOMAIN 498..534
FT /note="MYND-type"
FT /evidence="ECO:0000259|PROSITE:PS50865"
FT REGION 34..61
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 156..183
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 559 AA; 59007 MW; 97AD26CA198285CC CRC64;
MEDSDSAAKQ LGLAEAAAVA AAAAGAAAAA AAAGGEAEEP VLSRDEDSEE DADSEAERET
PRVTAVAVMA AVRFVRSGFR CLLNEAPSVA EVTTVTVANV GAAADNVFTT SVANAASISG
HVLSGRTALQ IGDSLNTEKA TLIVVHTDGS IVETTGLKGP AAPLTPGPQS PPTPLAPGQE
KGGTKYNWDP SVYDSELPVR CRNISGTLYK NRLGSGGRGR CIKQGENWYS PTEFEAMAGR
ASSKDWKRSI RYAGRPLQCL IQDGILNPHA ASCTCAACCD DMTLSGPVRL FVPYKRRKKE
NELPTTPVKK DSPKNITLLP ATAATTFTVT PSGQITTSGA LTFDRASTVE ATAVISESPA
QGDVFAGATV QEASVQPPCR ASHPEPHYPG YQDSCQIAPF PEAALPTSHP KIVLTSLPAL
AVPPPTPTKV APPALVNGLE LSEPRSWLYL EEMVNSLLNT AQQLKTLFEQ AKHASTYREA
AANQAKIHAD AERKEQSCVN CGREAMSECT GCHKVNYCST FCQRKDWKDH QHICGQSAAV
TVQADEVHVA ESVMEKVTV
//
