ID G3RDU8_GORGO Unreviewed; 412 AA.
AC G3RDU8;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE SubName: Full=Protein kinase domain containing, cytoplasmic {ECO:0000313|Ensembl:ENSGGOP00000013710.2};
GN Name=PKDCC {ECO:0000313|Ensembl:ENSGGOP00000013710.2};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000013710.2, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000013710.2, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000013710.2, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000013710.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; CABD030013227; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G3RDU8; -.
DR STRING; 9593.ENSGGOP00000013710; -.
DR Ensembl; ENSGGOT00000014104.3; ENSGGOP00000013710.2; ENSGGOG00000014054.3.
DR eggNOG; KOG1187; Eukaryota.
DR GeneTree; ENSGT00390000001205; -.
DR HOGENOM; CLU_044025_1_0_1; -.
DR InParanoid; G3RDU8; -.
DR OMA; HEGCLLS; -.
DR TreeFam; TF329248; -.
DR Proteomes; UP000001519; Chromosome 2A.
DR Bgee; ENSGGOG00000014054; Expressed in heart and 6 other cell types or tissues.
DR GO; GO:0005576; C:extracellular region; IBA:GO_Central.
DR GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IBA:GO_Central.
DR GO; GO:0030282; P:bone mineralization; IEA:Ensembl.
DR GO; GO:0048566; P:embryonic digestive tract development; IEA:Ensembl.
DR GO; GO:0035108; P:limb morphogenesis; IEA:Ensembl.
DR GO; GO:0048286; P:lung alveolus development; IEA:Ensembl.
DR GO; GO:0035264; P:multicellular organism growth; IEA:Ensembl.
DR GO; GO:0042997; P:negative regulation of Golgi to plasma membrane protein transport; IEA:Ensembl.
DR GO; GO:0030501; P:positive regulation of bone mineralization; IEA:Ensembl.
DR GO; GO:0032332; P:positive regulation of chondrocyte differentiation; IEA:Ensembl.
DR GO; GO:0060021; P:roof of mouth development; IEA:Ensembl.
DR GO; GO:0001501; P:skeletal system development; IBA:GO_Central.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR022049; FAM69_kinase_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR042983; PKDCC.
DR InterPro; IPR000719; Prot_kinase_dom.
DR PANTHER; PTHR46448:SF3; EXTRACELLULAR TYROSINE-PROTEIN KINASE PKDCC; 1.
DR PANTHER; PTHR46448; PROTEIN KINASE DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF12260; PIP49_C; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001519}.
FT DOMAIN 57..412
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 1..48
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 14..45
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 412 AA; 45654 MW; 66B2E467702AC97A CRC64;
PERRRLMDLA PGGPGLPRPR PPWARPLPDG APGWPPAPGP GSPGPGPRLG CAALRNVSGA
QYVGSGYTKA VYRVRLPGGA AVALKAVDFS GHDLGSCVRE FGVRRGCYRL AAHKLLKEMV
LLERLRHPNV LQLYGYCYQD SEDIPDTLTT ITELGAPVEM IQLLQTSWED RFRICLSLGR
LLHHLAHSPL GSVTLLDFRP RQFVLVDGEL KVTDLDDARV EETPCAGSTD CILEFPARNF
TLPCSAQGWC EGMNEKRNLY NAYRFFFTYL LPHSAPPSLR PLLDSIVNAT GELAWGVDET
LAQLEKVLHL YRSGQYLQNS TASSSTEYQR IPDSTIPQED YRCWPSYHHG SCLLSVFNLA
EAVDVCESHA QCRAFVVTNQ TTWTGRQLVF FKTGWSQVVP DPNKTTYVKA SG
//
