ID G3RGI1_GORGO Unreviewed; 125 AA.
AC G3RGI1;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE RecName: Full=Secretin {ECO:0000256|ARBA:ARBA00015460};
GN Name=SCT {ECO:0000313|Ensembl:ENSGGOP00000014731.2};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000014731.2, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000014731.2, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000014731.2, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000014731.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the glucagon family.
CC {ECO:0000256|ARBA:ARBA00008369}.
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DR EMBL; CABD030077011; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_004050413.1; XM_004050365.2.
DR AlphaFoldDB; G3RGI1; -.
DR STRING; 9593.ENSGGOP00000014731; -.
DR Ensembl; ENSGGOT00000015148.3; ENSGGOP00000014731.2; ENSGGOG00000015101.3.
DR GeneID; 101138524; -.
DR KEGG; ggo:101138524; -.
DR CTD; 6343; -.
DR eggNOG; ENOG502R8F0; Eukaryota.
DR GeneTree; ENSGT00390000002624; -.
DR HOGENOM; CLU_1991937_0_0_1; -.
DR InParanoid; G3RGI1; -.
DR OMA; HAPFPWL; -.
DR OrthoDB; 4605098at2759; -.
DR TreeFam; TF338215; -.
DR Proteomes; UP000001519; Chromosome 11.
DR Bgee; ENSGGOG00000015101; Expressed in heart and 5 other cell types or tissues.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0001664; F:G protein-coupled receptor binding; IEA:Ensembl.
DR GO; GO:0005179; F:hormone activity; IEA:InterPro.
DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central.
DR GO; GO:0007420; P:brain development; IBA:GO_Central.
DR GO; GO:1903640; P:negative regulation of gastrin-induced gastric acid secretion; IBA:GO_Central.
DR GO; GO:0090187; P:positive regulation of pancreatic juice secretion; IBA:GO_Central.
DR GO; GO:0090274; P:positive regulation of somatostatin secretion; IBA:GO_Central.
DR InterPro; IPR000532; Glucagon_GIP_secretin_VIP.
DR InterPro; IPR015675; Prosecretin.
DR PANTHER; PTHR17378; SECRETIN; 1.
DR PANTHER; PTHR17378:SF1; SECRETIN; 1.
DR Pfam; PF00123; Hormone_2; 1.
DR SMART; SM00070; GLUCA; 1.
DR PROSITE; PS00260; GLUCAGON; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..125
FT /note="Secretin"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003452671"
FT DOMAIN 28..50
FT /note="Glucagon / GIP / secretin / VIP family"
FT /evidence="ECO:0000259|PROSITE:PS00260"
SQ SEQUENCE 125 AA; 13448 MW; DB225BD790451971 CRC64;
MAPRHLLLLL LLLGGSAARP APPRARRHSD GTFTSELSRL REGARLQRLL QGLVGKRSEQ
DAENSTAWTR LGAGLLCPSG SNMPILQAWM PLDVTWSPWL PPGPRPGVMV SEPAGAAAEG
TLRPR
//
