ID G3RHA1_GORGO Unreviewed; 767 AA.
AC G3RHA1;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 71.
DE RecName: Full=Aryl hydrocarbon receptor nuclear translocator {ECO:0000256|ARBA:ARBA00039652};
GN Name=ARNT {ECO:0000313|Ensembl:ENSGGOP00000015019.3};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000015019.3, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000015019.3, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000015019.3, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000015019.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; CABD030006388; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030006389; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030006390; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G3RHA1; -.
DR Ensembl; ENSGGOT00000015448.3; ENSGGOP00000015019.3; ENSGGOG00000015383.3.
DR eggNOG; KOG3561; Eukaryota.
DR GeneTree; ENSGT00940000157585; -.
DR TreeFam; TF319983; -.
DR Proteomes; UP000001519; Chromosome 1.
DR Bgee; ENSGGOG00000015383; Expressed in liver and 6 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:InterPro.
DR GO; GO:0005667; C:transcription regulator complex; IEA:InterPro.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR CDD; cd18947; bHLH-PAS_ARNT; 1.
DR CDD; cd00130; PAS; 2.
DR Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 2.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR001067; Nuc_translocat.
DR InterPro; IPR001610; PAC.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013767; PAS_fold.
DR NCBIfam; TIGR00229; sensory_box; 1.
DR PANTHER; PTHR23042:SF50; ARYL HYDROCARBON RECEPTOR NUCLEAR TRANSLOCATOR; 1.
DR PANTHER; PTHR23042; CIRCADIAN PROTEIN CLOCK/ARNT/BMAL/PAS; 1.
DR Pfam; PF00010; HLH; 1.
DR Pfam; PF00989; PAS; 1.
DR Pfam; PF14598; PAS_11; 1.
DR PRINTS; PR00785; NCTRNSLOCATR.
DR SMART; SM00353; HLH; 1.
DR SMART; SM00086; PAC; 1.
DR SMART; SM00091; PAS; 2.
DR SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR SUPFAM; SSF88633; Positive stranded ssRNA viruses; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 2.
DR PROSITE; PS50888; BHLH; 1.
DR PROSITE; PS50112; PAS; 2.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 67..120
FT /note="BHLH"
FT /evidence="ECO:0000259|PROSITE:PS50888"
FT DOMAIN 139..213
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 346..397
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT REGION 443..470
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 650..767
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 443..463
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 670..701
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 709..756
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 767 AA; 84414 MW; 48140D189732F766 CRC64;
MADHLFKNVY FIIFLTEMTS DVPSLGPAIA SGNPGPGIQG GGAIVQRAIK RRPGCDDDQM
SNDKERFARE NHSEIERRRR NKMTAYITEL SDMVPTCSAL ARKPDKLTIL RMAVSHMKSL
RGTGNTSTDG SYKPSFLTDQ ELKHLILEAA DGFLFIVSCE TGRVVYVSDS VTPVLNQPQS
EWFGSTLYDQ VHPDDVDKLR EQLSTSENAL TGRILDLKTG TVKKEGQQSS MRMCMGSRRS
FICRMRCGSS SVDPVSVNRL SFVRNRCRNG LGSVKDGEPH FVVVHCTGYI KAWPPAGVSL
PDDDPEAGQG SKFCLVAIGR LQVTSSPNCT DMSNVCQPTE FISRHNIEGI FTFVDHRCVA
TVGYQPQELL GKNIVEFCHP EDQQLLRDSF QQVVKLKGQV LSVMFRFRSK NQEWLWMRTS
SFTFQNPYSD EIEYIICTNT NVKNSSQEPR PTLSNTIQRP QLGPTANLPL EMGSGQLAPR
QQQQQTELDM VPGRDGLASY NHSQVVQPVT TTGPEHSKPL EKSDGLFAQD RDPRFSEIYH
NINADQSKGI SSSTVPATQQ LFSQGNTFPP TPRPAENFRN SGLAPPVTIV QPSASAGQML
AQISRHSNPT QGAAPTWTPT TRSGFSAQQV ATQATAKTRT SQFGVGSFQT PSSFSSMSLP
GAPTASPGAA AYPSLTNRGS NFAPETGQTA GQFQTRTAEG VGVWPQWQGQ QPHHRSSSSE
QHVQQPPAQQ PGQPEVFQEM LSMLGDQSNS YNNEEFPDLT MFPPFSE
//
