ID G3RJ30_GORGO Unreviewed; 1566 AA.
AC G3RJ30;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=Transient receptor potential cation channel subfamily M member 3 {ECO:0000313|Ensembl:ENSGGOP00000015701.3};
GN Name=TRPM3 {ECO:0000313|Ensembl:ENSGGOP00000015701.3};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000015701.3, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000015701.3, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000015701.3, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000015701.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; CABD030064216; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030064217; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030064218; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030064219; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030064220; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030064221; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030064222; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030064223; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030064224; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030064225; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSGGOT00000016151.3; ENSGGOP00000015701.3; ENSGGOG00000016086.3.
DR eggNOG; KOG3614; Eukaryota.
DR GeneTree; ENSGT00940000157366; -.
DR HOGENOM; CLU_001390_4_1_1; -.
DR TreeFam; TF314204; -.
DR Proteomes; UP000001519; Chromosome 9.
DR Bgee; ENSGGOG00000016086; Expressed in adult mammalian kidney and 3 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005216; F:monoatomic ion channel activity; IEA:InterPro.
DR GO; GO:0051262; P:protein tetramerization; IEA:InterPro.
DR Gene3D; 1.20.5.1010; TRPM, tetramerisation domain; 1.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR041491; TRPM_SLOG.
DR InterPro; IPR032415; TRPM_tetra.
DR InterPro; IPR037162; TRPM_tetra_sf.
DR PANTHER; PTHR13800:SF7; TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY M MEMBER 3; 1.
DR PANTHER; PTHR13800; TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL, SUBFAMILY M, MEMBER 6; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF18139; LSDAT_euk; 1.
DR Pfam; PF16519; TRPM_tetra; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023303};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00023303}.
FT TRANSMEM 732..751
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 799..817
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 829..847
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 868..888
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 946..971
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 2..265
FT /note="TRPM SLOG"
FT /evidence="ECO:0000259|Pfam:PF18139"
FT DOMAIN 739..980
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 1074..1129
FT /note="TRPM tetramerisation"
FT /evidence="ECO:0000259|Pfam:PF16519"
FT REGION 1293..1312
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1445..1566
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1077..1135
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1293..1308
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1445..1464
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1470..1492
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1566 AA; 178931 MW; 1B9229BD9B87FE0A CRC64;
MYVRVSFDTK PDLLLHLMTK EWQLELPKLL ISVHGGLQNF ELQPKLKQVF GKGLIKAAMT
TGAWIFTGGV NTGVIRHVGD ALKDHASKSR GKICTIGIAP WGIVENQEDL IGRDVVRPYQ
TMSNPMSKLT VLNSMHSHFI LADNGTTGKY GAEVKLRRQL EKHISLQKIN TRIGQGVPVV
ALIVEGGPNV ISIVLEYLRD TPPVPVVVCD GSGRASDILA FGHKYSEEGG LINESLRDQL
LVTIQKTFTY TRTQAQHLFI ILMECMKKKE LITVFRMGSE GHQDIDLAIL TALLKGANAS
APDQLSLALA WNRVDIARSQ IFIYGQQWPV GSLEQAMLDA LVLDRVDFVK LLIENGVSMH
RFLTISRLEE LYNTRHGPSN TLYHLVRDVK KREYPGFGWI YFKGNLPPDY RISLIDIGLV
IEYLMGGAYR CNYTRKRFRT LYHNLFGPKR PKALKLLGME DDIPLRRGRK TTKKREEEVD
IDLDDPEINH FPFPFHELMV WAVLMKRQKM ALFFWQHGEE AMAKALVACK LCKAMAHEAS
ENDMVDDISQ ELNHNSRDFG QLAVELLDQS YKQDEQLAMK LLTYELKNWS NATCLQLAVA
AKHRDFIAHT CSQMLLTDMW MGRLRMRKNS GLKVILGILL PPSILSLEFK NKDDMPYMSQ
AQEIHLQEKE AEEPEKPTKE KEEEDMELTA MLGRNNGESS RKKDEEEVQS RHRLIPLGRK
IYEFYNAPIV KFWFYTLAYI GYLMLFNYIV LVKMERWPST QEWIVISYIF TLGIEKMREI
LMSEPGKLLQ KVKVWLQEYW NVTDLIAILL FSVGMILRLQ DQPFRSDGRV IYCVNIIYWY
IRLLDIFGVN KYLGPYVMMI GKMMIDMMYF VIIMLVVLMS FGVARQAILF PNEEPSWKLA
KNIFYMPYWM IYGEVFADQI DPPCGQNETR EDGKIIQLPP CKTGAWIVPA IMACYLLVAN
ILLVNLLIAV FNNTFFEVKS ISNQVWKFQR YQLIMTFHER PVLPPPLIIF SHMTMIFQHL
CCRWRKQESD PDERDYGLKL FITDDELKKV HDFEEQCIEE YFREKDDRFN SSNDERIRVT
SERVENMSMR LEEVNEREHS MKASLQTVDI RLAQLEDLIG RMATALERLT GLERAESNKI
RSRTSSDCTD AAYIVRQSSF NSQEGNTFKL QESIDPAGEE TMSPTSPTLM PRMRSHSFYS
VNMKDKGGIE KLESIFKERS LSLHRATSSH SVAKEPKAPA APANTLAIVP DSRRPSSCID
IYVSAMDELH CDIDPLDNSV NILGLGEPSF STPVPSTAPS SSAYATLAPT DRPPSRSIDF
EDITSMDTRS FSSDYTHLPE CQNPWDSERP MYHTIERSKS SRYLATTPFL LEEAPIVKSH
SFMFSPSRSY YANFGVPVKT AEYTSITDCI DTRCVNAPQA IADRAAFPGG LGDKVEDLTC
CHPEREAELS HPSSDSEENE AKGRRATIAI SSQEGDNSER TLSNNITVPK IERANSYSAE
EPSAPYAHTR KSFSISDKLD RQRNTASLRN PFQRSKSSKP EGRGDSLSMR RLSRTSAFQS
FESKHN
//