ID G3RLG1_GORGO Unreviewed; 1980 AA.
AC G3RLG1;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 64.
DE SubName: Full=Structural maintenance of chromosomes flexible hinge domain containing 1 {ECO:0000313|Ensembl:ENSGGOP00000016608.3};
GN Name=SMCHD1 {ECO:0000313|Ensembl:ENSGGOP00000016608.3};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000016608.3, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000016608.3, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000016608.3, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000016608.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; CABD030107344; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030107345; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030107346; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030107347; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030107348; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030107349; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030107350; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030107351; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030107352; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030107353; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSGGOT00000017074.3; ENSGGOP00000016608.3; ENSGGOG00000017005.3.
DR eggNOG; ENOG502QREW; Eukaryota.
DR GeneTree; ENSGT00390000006950; -.
DR HOGENOM; CLU_002288_1_0_1; -.
DR TreeFam; TF329426; -.
DR Proteomes; UP000001519; Chromosome 18.
DR Bgee; ENSGGOG00000017005; Expressed in testis and 6 other cell types or tissues.
DR GO; GO:0005694; C:chromosome; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0051276; P:chromosome organization; IEA:InterPro.
DR GO; GO:0006302; P:double-strand break repair; IEA:InterPro.
DR CDD; cd16937; HATPase_SMCHD1-like; 1.
DR Gene3D; 1.20.1060.20; -; 1.
DR Gene3D; 3.30.70.1620; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR010935; SMC_hinge.
DR InterPro; IPR036277; SMC_hinge_sf.
DR InterPro; IPR038892; SMCHD1.
DR PANTHER; PTHR22640:SF2; STRUCTURAL MAINTENANCE OF CHROMOSOMES FLEXIBLE HINGE DOMAIN-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR22640; UNCHARACTERIZED; 1.
DR Pfam; PF13589; HATPase_c_3; 1.
DR Pfam; PF06470; SMC_hinge; 1.
DR SMART; SM00968; SMC_hinge; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF75553; Smc hinge domain; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000001519}.
FT DOMAIN 1690..1817
FT /note="SMC hinge"
FT /evidence="ECO:0000259|SMART:SM00968"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1614..1648
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1980 AA; 223076 MW; E3F93893FDFCBD89 CRC64;
MAAADGGGPG GASVGTKEDG GGVGHRTVYL FDRREKESEL GDRPLQVGER LDYAGFRASV
CQTLGISPEE KFVITTTSRK EITCDNFDET VKDGVTLYLL QSVNQLLLTA TKERIDFLPH
YDTLVKSGMY EYYASEGQNP LPFALAELID NSLSATSRNI GVRRIQIKLL FDETQGKPAV
AVIDNGRGMT SKQLNNWAVY RLSKFTRQGD FESDHSGYVR PVPVPRSLNS DISYFGVGGK
QAVFFVGQSA RMISKPADSQ DVHELVLSKE DFEKKEKNKE AIYSGYIRNR KPSDSVHITN
DDERFLHHLI IEEKEKDSFT AVVITGVQPE HIQYLKNYFH LWTRQLAHIY HYYIHGPKGN
EIRTSKEVEP LNNIDIEISM FEKGKVPKIV NLREIQDDMQ TLYVNTAADS FEFKAHVEGD
GVVEGIIRYH PFLYDRETYP DDPCFPSKLK DEDDEDDCFI LEKAARGKRP IFECFWNGRL
IPYTSVEDFD WCTPPKKRGL APIECYNRIS GALFTNDKFQ VSTNKLTFMD LELKLKDKNT
LFTRILNGQE QRMKIDREFA LWLKDCHEKY DKQIKFTLFK GIITRPDLPS KKQGPWATYA
AIEWDGKIYK AGQLVKTIKT LPLFYGSIVR FFLYGDHDGE VYATGGEVQI AMEPQALYDE
VKTVPIAKLD RTVAEKAVKK YVEDEMARLP DRLSITWPEG DELLPNEIRP AGTPIGALRI
EILNKKGEAM QKLPGTSHGG SKKLLVELKV ILHSSSGNKE IISHISQHGG KWPYWFKKME
NIQKLGNYTL KLQVVLNESN ADTYAGRPLP SKAIKFSVKE GKPEKFSFGV LDLPFRVGVP
FNIPLEFQDE FGHTSQLVTD IQPVLEASGL SLHYEEITKG PNCVIRGVTA KGPVNSCQGK
NYNLKVTLPG LKEDSQISKI RLLPGHPRRL KVKPDSEILV IENGTAFPFQ VEVLDESDNI
TAQPKLIVHC KFSGAPNLPV YVVDCSSSGT SILTGSAIQV QNIKKDQTLK ARIEIPSCKD
VAPVEKTIKL LPSSHVARLQ IFSVEGQKAI QIKHQDEVNW IAGDIMHNLI FQMYDEGERE
INITSALAEK IKVNWTPEIN KEHLLQGLLP DVQVPTSVKD MRYCQVSFQD DHVSLESAFT
VRPLPDEPKH LKCEMKGGKT VQMGQELQGE VVIIITDQYG NQIQAFSPSS LSSLSIAGVG
LDSSNLKTTF QENTQSISVR GIKFIPGPPG NKDLCFTWRE FSDFIRVQLI SGPPAKLLLI
DWPELKESIP VINGRDLQNP IIVQLCDQWD NPAPVQHVKI SLTKASNLKL MPSNQQHKTD
EKGRANLGVF SVFAPRGEHT LQVKAIYNKS IIEGPIIKLM ILPDPEKPVR LNVKYDKDAS
FLAGGLFTDF MISVISEDDS IIKNINPARI SMKMWKLSTS GNRPPANAET FSCNKIKDND
KEDGLCAIVI VEVLPNQPVK LVPKIKPPTP AVSNVRSVAS RTLVRDLHLS ITDDYDNHTG
IDLVGTIIAT IKGSNEEDTD TPLFIGKVRT LEFPFVNGSA EIMSLVLAES SPGRDSTEYF
IVFEPRLPLL SRTLEPYILP FMFYNDVKKQ QQMAALTKEK DQLSQSIVMY KSLFEASQQL
LNEMKCQVEE ARLKEAQLQN ELKIHNIDIP TTQQVPHIEA LLKRKLSEQE ELKKKPRRSC
TLPNYTKGSG DVLGKIAHLA QIEDDRAAMV ISWHLASDMD CVVTLTTDAA RRIYDETQGR
QQVLPLDSIY KKTLPDWKRP LPHFRNGKLY FKPIGDPVFA RDLLTFPDNI EHCETVFGML
LGDTIILDNL DAANHYRKEV VKITHCPTLL TRDGDRIRSN GKFGGLQNKA PPMDKLRGMV
FGAPVPKQCL ILGEQIDLLQ QYRSAVCKLD SVNKDLNSQL EYLRTPDMKK KKQELDEHEK
NLKLIEEKLG MTPIRKCNDS LRHSPKVETT DCPVPPKRMR REATRQNSVI PIVTKTLSCC
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