ID G3RMD3_GORGO Unreviewed; 892 AA.
AC G3RMD3;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 49.
DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSGGOP00000016947.2};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000016947.2, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000016947.2, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000016947.2, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000016947.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; CABD030038289; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030038290; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSGGOT00000025492.2; ENSGGOP00000020064.2; ENSGGOG00000027717.2.
DR Ensembl; ENSGGOT00000034072.2; ENSGGOP00000016947.2; ENSGGOG00000026951.2.
DR eggNOG; ENOG502QWKG; Eukaryota.
DR GeneTree; ENSGT00410000025651; -.
DR OMA; FRETAYE; -.
DR TreeFam; TF337168; -.
DR Proteomes; UP000001519; Chromosome 5.
DR GO; GO:0043022; F:ribosome binding; IBA:GO_Central.
DR GO; GO:0004521; F:RNA endonuclease activity; IBA:GO_Central.
DR GO; GO:0006402; P:mRNA catabolic process; IBA:GO_Central.
DR GO; GO:0016075; P:rRNA catabolic process; IBA:GO_Central.
DR Gene3D; 3.30.950.30; Schlafen, AAA domain; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR031450; Poxin-SLFN/SLFN_N.
DR InterPro; IPR029684; Schlafen.
DR InterPro; IPR007421; Schlafen_AlbA_2_dom.
DR InterPro; IPR038461; Schlafen_AlbA_2_dom_sf.
DR InterPro; IPR048729; SLFN_GTPase-like.
DR PANTHER; PTHR12155:SF30; PROTEIN SLFN14; 1.
DR PANTHER; PTHR12155; SCHLAFEN; 1.
DR Pfam; PF17057; B3R; 1.
DR Pfam; PF04326; SLFN_AlbA_2; 1.
DR Pfam; PF21026; SLFN_GTPase-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001519}.
FT DOMAIN 83..204
FT /note="Poxin-Schlafen/Schlafen-like N-terminal"
FT /evidence="ECO:0000259|Pfam:PF17057"
FT DOMAIN 206..321
FT /note="Schlafen AlbA-2"
FT /evidence="ECO:0000259|Pfam:PF04326"
FT DOMAIN 380..515
FT /note="Schlafen GTPase-like"
FT /evidence="ECO:0000259|Pfam:PF21026"
SQ SEQUENCE 892 AA; 102021 MW; 3D8D40AB6CF2A44F CRC64;
MERLKTDTEM PYPEVIVDVG RVIFGEENRK KMTNSCLKRS ENSRIIRAIC ALLNSGGGVI
KAEIDDKTYS YQCHGLGQDL ETSFQKLLPS GSQKYLDYMQ QGHNLLIFVK SWSPDVFSLP
LRICSLRSNL YRRDVTSAIN LSASSALELL REKGFRAQRG RPRVKKLHPQ QVLNRYIQEE
EDMRILASEF FKKDKLMYKE KLNFTESTHV EFKRFTTKKV IPRIKEMLPH YVSAFANTQG
GYVLIGVDDK SKEVVGCKWE KVNPDLLKKE IENCIEKLPT FHFCCEKPKV NFTTKILNVY
QKDVLDGYVC VIQVEPFCCV VFAEAPDSWI MKDNSVTRLT AEQWVVMMLD TQSGKGNNIT
HPYRFHDFTY AVPRAFTPYE EVQFKPESLC KKLFSDHKEL EGLMKTLIHP CSQGIVIFSR
SWAGDVGFRK EQNVLCDALL IAVNSPVVLY TILIDPDWPG GLEYARNTAH QLKQKLQTVG
GYTGKVCIIP RLIHLSSTQS RPGEIPVRYP RSYRLADEEE MEDLLQALVV VSLSSRSLLS
DQMGCEFFNL LIMEQSQLLS ESLQKTRELF IYCFPGVRKT ALAIKIMEKI KDLFHCKPKE
ILYVCESDSL KDFVTQQTTC QAVTRKTFMQ GEFLKIKHIV MDETENFCSK YGNWYMKAKN
ITHPKAKGTG SENLHHGILW LFLDPFQIHH ADVNGLPPPS AQFPRKTITS GIHCALEIAK
VMKEEMKRIK ENPPSNMSPD TLALFSETAY EEATCAQALP GVCETKTNLT TEQIANYVAR
KCHSLFQCGY LPKDIAILCR RGEDRGRYRL ALLKAMELIE THRPSEVVFS PATGVWGSHI
VLDSIQQFSG LERTIVFGLS PECDQSEEFH KLCFASRAIK HLYLLYEKRA AF
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