ID G3RME5_GORGO Unreviewed; 670 AA.
AC G3RME5;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 48.
DE SubName: Full=Rho GTPase activating protein 28 {ECO:0000313|Ensembl:ENSGGOP00000016959.2};
GN Name=ARHGAP28 {ECO:0000313|Ensembl:ENSGGOP00000016959.2};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000016959.2, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000016959.2, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000016959.2, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000016959.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; CABD030107212; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030107213; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030107214; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030107215; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030107216; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_018869794.1; XM_019014249.1.
DR AlphaFoldDB; G3RME5; -.
DR Ensembl; ENSGGOT00000027760.2; ENSGGOP00000016959.2; ENSGGOG00000000529.3.
DR GeneTree; ENSGT00940000158929; -.
DR HOGENOM; CLU_023268_2_0_1; -.
DR OrthoDB; 11483at2759; -.
DR Proteomes; UP000001519; Chromosome 18.
DR Bgee; ENSGGOG00000000529; Expressed in testis and 5 other cell types or tissues.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd04391; RhoGAP_ARHGAP18; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR14963; RHO GTPASE ACTIVATING PROTEIN 18,19-RELATED; 1.
DR PANTHER; PTHR14963:SF5; RHO GTPASE-ACTIVATING PROTEIN 28; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001519}.
FT DOMAIN 328..525
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 1..55
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 124..186
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 560..579
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..23
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 25..39
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 160..177
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 670 AA; 75748 MW; 85C78759F88E0112 CRC64;
MLSNESLHPP AFSRSNSEAS VDSASMEDFW REIESIKDSS MGGQEEPPPA EVTPVDEGEL
EAEWLQDVGL STLISGDEEE DGKALLSTLT RTQAAAVEKR YNTYTQTMRK KNKQSIRDVR
DIFGVSESPP RDTCGNHTNQ LDGTKEEREL PRVIKTSGSM PDDASLNSTT LSDASQDKEG
SFAVPRSDSV AVLETIPVLP VHSNGSPEPG QPVQNAISDD DYLEKNIPPE AEELSFEVSY
SEMVTEALKR NKLKKSEIKK EDYVLTKFIV QKTRFGLTEA GDLSAEDMKK IRHLSLIELT
AFFDAFGIQL KRNKTEKVKG RDNGIFGVPL TVLLDSDRKK DPGVKVPLVL QKFFEKVEES
GLESEGIFRL SGCTAKVKQY REELDAKFNA DKFKWDKMCH REAAVMLKAF FRELPTSLFP
VEYIPAFISL MERGPHVKVQ FQALHLMVMA LPDANRDAAQ ALMTFFNKVI ANESKNRMSL
WNISTVMAPN LFFSRSKHSD YEELLLANTA AHIIRLMLKY QKILWKVPSF LITQVRRMNE
ATMLLKKQLP SVRKLLRRKT LERETASPKT SKVLQKSPSA RRMSDVPEGV IRVHAPLLSK
VSMAIQLNNQ TKAKDILAKF QYENRILHWQ RAALSFLNGK WVKKEREEST EANRSPKHVF
LFTIGLDIST
//
