ID G3RMH6_GORGO Unreviewed; 479 AA.
AC G3RMH6;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 64.
DE RecName: Full=Double-stranded RNA-binding protein Staufen homolog 2 {ECO:0000256|ARBA:ARBA00024122};
GN Name=STAU2 {ECO:0000313|Ensembl:ENSGGOP00000016990.2};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000016990.2, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000016990.2, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000016990.2, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000016990.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CABD030058131; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030058132; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030058133; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030058134; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030058135; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030058136; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030058137; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030058138; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030058139; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030058140; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G3RMH6; -.
DR SMR; G3RMH6; -.
DR Ensembl; ENSGGOT00000028892.2; ENSGGOP00000016990.2; ENSGGOG00000026508.2.
DR eggNOG; KOG3732; Eukaryota.
DR GeneTree; ENSGT00940000154977; -.
DR HOGENOM; CLU_009602_2_0_1; -.
DR TreeFam; TF350296; -.
DR Proteomes; UP000001519; Chromosome 8.
DR Bgee; ENSGGOG00000026508; Expressed in prefrontal cortex and 5 other cell types or tissues.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR CDD; cd19882; DSRM_STAU2_rpt2; 1.
DR CDD; cd19884; DSRM_STAU2_rpt3; 1.
DR CDD; cd19886; DSRM_STAU2_rpt4; 1.
DR Gene3D; 3.30.160.20; -; 4.
DR InterPro; IPR014720; dsRBD_dom.
DR InterPro; IPR044464; STAU2_DSRM_2.
DR InterPro; IPR044473; STAU2_DSRM_3.
DR InterPro; IPR044474; STAU2_DSRM_4.
DR InterPro; IPR032478; Staufen_C.
DR PANTHER; PTHR46054:SF1; DOUBLE-STRANDED RNA-BINDING PROTEIN STAUFEN HOMOLOG 2; 1.
DR PANTHER; PTHR46054; MATERNAL EFFECT PROTEIN STAUFEN; 1.
DR Pfam; PF00035; dsrm; 3.
DR Pfam; PF16482; Staufen_C; 1.
DR SMART; SM00358; DSRM; 3.
DR SUPFAM; SSF54768; dsRNA-binding domain-like; 4.
DR PROSITE; PS50137; DS_RBD; 3.
PE 4: Predicted;
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW ProRule:PRU00266}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 63..149
FT /note="DRBM"
FT /evidence="ECO:0000259|PROSITE:PS50137"
FT DOMAIN 175..242
FT /note="DRBM"
FT /evidence="ECO:0000259|PROSITE:PS50137"
FT DOMAIN 275..343
FT /note="DRBM"
FT /evidence="ECO:0000259|PROSITE:PS50137"
FT REGION 30..62
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 146..171
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 355..377
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 479 AA; 52769 MW; A799D1C30D1DF8B9 CRC64;
MLQINQMFSV QLSLGEQTWE SEGSSIKKAQ QAVANKALTE STLPKPVQKP PKSNVNNNPG
SITPTVELNG LAMKRGEPAI YRPLDPKPFP NYRANYNFRG MYNQRYHCPV PKIFYVQLTV
GNNEFFGEGK TRQAARHNAA MKALQALQNE PIPERSPQNG ESGKDMDDDK DANKSEISLV
FEIALKRNMP VSFEVIKESG PPHMKSFVTR VSVGEFSAEG EGNSKKLSKK RAATTVLQEL
KKLPPLPVVE KPKLFFKKRP KTIVKAGPEY GQGMNPISRL AQIQQAKKEK EPDYVLLSER
GMPRRREFVM QVKVGNEVAT GTGPNKKIAK KNAAEAMLLQ LGYKASTNLQ DQLEKTGENK
GWSGPKPGFP EPTNNTPKGI LHLSPDVYQE MEASRHKVIS GTTLGYLSPK DMNQPSSSFF
SISPTSNSSA TIARELLMNG TSSTAEAIGL KGSSPTPPCS PVQPSKQLEY LARIQGFQV
//
