GenomeNet

Database: UniProt
Entry: G3RMI4_GORGO
LinkDB: G3RMI4_GORGO
Original site: G3RMI4_GORGO 
ID   G3RMI4_GORGO            Unreviewed;      4938 AA.
AC   G3RMI4;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 2.
DT   28-MAR-2018, entry version 46.
DE   SubName: Full=Ryanodine receptor 1 {ECO:0000313|Ensembl:ENSGGOP00000016998};
GN   Name=RYR1 {ECO:0000313|Ensembl:ENSGGOP00000016998};
OS   Gorilla gorilla gorilla (Western lowland gorilla).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Gorilla.
OX   NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000016998, ECO:0000313|Proteomes:UP000001519};
RN   [1] {ECO:0000313|Ensembl:ENSGGOP00000016998, ECO:0000313|Proteomes:UP000001519}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Scally A.;
RT   "Insights into the evolution of the great apes provided by the gorilla
RT   genome.";
RL   Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSGGOP00000016998}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
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DR   EMBL; CABD030113423; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030113424; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030113425; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030113426; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030113427; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030113428; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030113429; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030113430; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030113431; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030113432; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 9593.ENSGGOP00000016998; -.
DR   Ensembl; ENSGGOT00000029090; ENSGGOP00000016998; ENSGGOG00000015461.
DR   GeneTree; ENSGT00760000119152; -.
DR   InParanoid; G3RMI4; -.
DR   OMA; DIPARRN; -.
DR   OrthoDB; EOG091G00T0; -.
DR   TreeFam; TF315244; -.
DR   Proteomes; UP000001519; Chromosome 19.
DR   Bgee; ENSGGOG00000015461; -.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   InterPro; IPR033215; RyR1.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 2.
DR   PANTHER; PTHR13715:SF15; PTHR13715:SF15; 2.
DR   Pfam; PF13833; EF-hand_8; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 1.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 2.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001519};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4461   4481       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4738   4760       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4819   4842       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      100    155       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      162    207       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      213    267       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      273    330       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      338    395       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      584    800       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1016   1211       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1359   1573       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   COILED     1872   1927       {ECO:0000256|SAM:Coils}.
FT   COILED     2916   2936       {ECO:0000256|SAM:Coils}.
FT   COILED     3678   3698       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   4938 AA;  555586 MW;  07F6396258547496 CRC64;
     CLSPGGQGCS ERCPSVPQDD EVVLQCSATV LKEQLKLCLA AEGFGNRLCF LEPTSNAQNV
     PPDLAICCFV LEQSLSVRAL QEMLANTVEA GVESSQGGGH RTLLYGHAIL LRHAHSRMYL
     SCLTTSRSMT DKLAFDVGLQ EDATGEACWW TMHPASKQRS EGEKVRVGDD IILVSVSSER
     YLHLSTASGE LQVDASFMQT LWNMNPICSR CEEGFVTGGH VLRLFHGHMD ECLTISPADS
     DDQRRLVYYE GGAVCTHARS LWRLEPLRIS WSGSHLRWGQ PLRVRHVTTG RYLALTEDQG
     LVVVDASKAH TKATSFCFRI SKEKLDVAPK RDVEGMGPPE IKYGESLCFV QHVASGLWLT
     YAAPDPKALR LGVLKKKAML HQEGHMDDAL SLTRCQQEES QAARMIHSTN GLYNQFIKSL
     DSFSGKPRGS GPPAGTALPI EGVILSLQDL IIYFEPPSED LQHEEKQSKL RSLRNRQSLF
     QEEGMLSMVL NCIDRLNVYT TAAHFAEFAG EEAAESWKEI VNLLYELLAS LIRGNRSNCA
     LFSTNLDWLV SKLDRLEASS GILEVLYCVL IESPEVLNII QENHIKSIIS LLDKHGRNHK
     VLDVLCSLCV CNGVAVRSNQ DLITENLLPG RELLLQTNLI NYVTSIRPNI FVGRAEGTTQ
     YSKWYFEVMV DEVTPFLTAQ ATHLRVGWAL TEGYSPYPGG GEGWGGNGVG DDLYSYGFDG
     LHLWTGHVAR PVTSPGQHLL APEDVISCCL DLSVPSISFR INGCPVQGVF ESFNLDGLFF
     PVVSFSAGVK VRFLLGGRHG EFKFLPPPGY APCHEAVLPR ERLHLEPIKE YRREGPRGPH
     LVGPSRCLSH TDFVPCPVDT VQIVLPPHLE RIREKLAENI HELWALTRIE QGWTYGPVRD
     DNKRLHPCLV DFHSLPEPER NYNLQMSGET LKTLLALGCH VGMADEKAED NLKKTKLPKT
     YMMSNGYKPA PLDLSHVRLT PAQTTLVDRL AENGHNVWAR DRVGQGWSYS AVQDIPARRN
     PRLVPYRLLD EATKRSNRDS LCQAVRTLLG YGYNIEPPDQ EPSQVENQSR CDRVRIFRAE
     KSYTVQSGRW YFEFEAVTTG EMRVGWARPE LRPDVELGAD ELAYVFNGHR GQRWHLGSEP
     FGRPWQPGDV VGCMIDLTEN TIIFTLNGEV LMSDSGSETA FREIEIGDGF LPVCSLGPGQ
     VGHLNLGQDV SSLRFFAICG LQEGFEPFAI NMQRPVTTWF SKGLPQFEPV PLEHPHYEVS
     RVDGTVDTPP CLRLTHRTWG SQNSLVEMLF LRLSLPVQFH QHFRCTAGAT PLAPPGLQPP
     AEDEARAAEP DPDYENLRRS AGGWGEAENG KEGTAKEGAP GGTPQAGGEA QPARAENEKD
     ATTEKNKKRG FLFKAKKVAM MTQPPATPTL PRLPHDVVPA DNRDDPEIIL NTTTYYYSVR
     VFAGQEPSCV WAGWVTPDYH QHDMSFDLSK VRVVTVTMGD EQGNVHSSLK CSNCYMVWGG
     DFVSPGQQGR ISHTDLVIGC LVDLATGLMT FTANGKESNT FFQVEPNTKL FPAVFVLPTH
     QNVIQFELGK QKNIMPLSAA MFQSERKNPA PQCPPRLEMQ MLMPVSWSRM PNHFLQVETR
     RAGERLGWAV QCQEPLTMMA LHIPEENRCM DILELSERLD LQRFHSHTLC LYRAVCALGN
     NRVAHALCSH VDQAQLLHAL EDAHLPGPLR AGYYDLLISI HLESACRSRR SMLSEYIVPL
     TPETRAITLF PPGRSTENGH PRHGLPGVGV TTSLRPPHHF SPPCFVAALP AAGAAEAPAR
     LSPAIPLEAL RDKALRMLGE AVRDGGQHAR DPVGGSVEFQ FVPVLKLVST LLVMGIFGDE
     DVKQILKMIE PEVFTEEEEE EEEEEEDEEE DEEEKEEDEE ETAQEKEDEE KEEEEAAEGE
     KEEGLEEGLL QMKLPESVKL QMCHLLEYFC DQELQHRVES LAAFAERYVD KLQANQRSRY
     GLLIKAFSMT AAETARRTRE FRSPPQEQIN MLLQFKDGTD EEDCPLPEEI RQDLLDFHQD
     LLAHCGIQLD GEEEEPEEET TLGSRLMSLL EKVRLVKKKE EKPEEERSAE ESKPRSLQEL
     VSHMVVRWAQ EDFVQSPELV RAMFSLLHRQ YDGLGELLRA LPRAYTISPS SVEDTMSLLE
     CLGQIRSLLI VQMGPQEENL MIQSIGNIMN NKVFYQHPNL MRALGMHETV MEVMVNVLGG
     GESKEIRFPK MVTSCCRFLC YFCRISRQNQ RSMFDHLSYL LENSGIGLGM QGSTPLDVAA
     ASVIDNNELA LALQEQDLEK VVSYLAGCGL QSCPMLVAKG YPDIGWNPCG GERYLDFLRF
     AVFVNGESVE ENANVVVRLL IRKPECFGPA LRGEGGSGLL AAIEEAIRIS EDPARDGPGI
     RRDRRREHFG EEPPEENRVH LGHAVMSFYA ALIDLLGRCA PEMHLIQAGK GEALRIRAIL
     RSLVPLEDLV GIISLPLQIP TLGKDGALVQ PKMSASFVPD HKASMVLFLD RVYGIENQDF
     LLHVLDVGFL PDMRAAASLD TATFSTTEMA LALNRYLCLA VLPLITKCAP LFAGTEHRAI
     MVDSMLHTVY RLSRGRSLTK AQRDVIEDCL MSLCRYIRPS MLQHLLRRLV FDVPILNEFA
     KMPLKLLTNH YERCWKYYCL PTGWANFGVT SEEELHLTRK LFWGIFDSLA HKKYDPELYR
     MAMPCLCAIA GALPPDYVDA SYSSKAEKKA TVDAEGNFDP RPVETLNVII PEKLDSFINK
     FAEYTHEKWA FDKIQNNWSY GENIDEELKT HPMLRPYKTF SEKDKEIYRW PIKESLKAMI
     AWEWTIEKAR EGEEEKTEKK KTRKISQSAQ TYDPREGYNP QPPDLSAVTL SRELQAMAEQ
     LAENYHNTWG RKKKQELEAK GGGTHPLLVP YDTLTAKEKA RDREKAQELL KFLQMNGYAV
     TRGLKDMELD SSSIEKRFAF GFLQQLLRWM DISQEFIAHL EAVVSSGRVE KSPHEQEIKF
     FAKILLPLIN QYFTNHCLYF LSTPAKVLGS GGHASNKEKE MITSLFCKLA ALVRHRVSLF
     GTDASAVVNC LHILARSLDA RTVMKSGPEI VKAGLRSFFE SASEDIEKMV ENLRLGKVSQ
     ARTQVKGVGQ NLTYTTVALL PVLTTLFQHI AQHQFGDDVI LDDVQVSCYR TLCSIYSLGT
     TKNTYVEKLR PALGECLARL AAAMPVAFLE PQLNEYNACS VYTTKSPRER AILGLPNSVE
     EMCPDIPVLE RLMADIGGLA ESGARYTEMP HVIEITLPML CSYLPRWWER GPEAPPPALP
     AGAPPPCTAV TSDHLNSLLG NILRIIVNNL GIDEASWMKR LAVFAQPIVS RARPELLQSH
     FIPTIGRLRK RAGKVVSEEE QLRLEAKAEA QEGELLVRDE FSVLCRDLYA LYPLLIRYVD
     NNRAQWLTEP NPSAEELFRM VGEIFIYWSK SHNFKREEQN FVVQNEINNM SFLTADNKSK
     MAKVGSGGSD QERTKKKRRG DRYSVQTSLI VATLKKMLPI GLNMCAPTDQ DLITLAKTRY
     ALKDTDEEVR EFLHNNLHLQ GKVEGSPSLR WQMALYRGVP GREEDADDPE KIVRRVQEVS
     AVLYYLDQTE HPYKSKKAVW HKLLSKQRRR AVVACFRMTR MGGREARRRA HRACNMFLES
     YKAAWIVTED HSFEDRMIDD LSKAGEQEEE EEEVEEKKPD PLHQLVLHFS RTALTEKSKL
     DEDYLYMAYA DIMAKSCHLE EGGENGEAEE EVEVSFEEKE MEKQRLLYQQ ARLHTRGAAE
     MVLQMISACK GETGAMVSST LKLGISILNG GNAEVQQKML DYLKDKKEVG FFQSIQALMQ
     TCSVLDLNAF ERQNKAEGLG MVNEDGTVIN RQNGNSPREK VMADDEFTQD LFRFLQLLCE
     GHNNDFQNYL RTQTGNTTTI NIIICTVDYL LRLQESISDF YWYYSGKDVI EEQGKRNFSK
     AMSVAKQVFN SLTEYIQGPC TGNQQSLAHS RLWDAVVGFL HVFAHMMMKL AQDSSQIELL
     KELLDLQKDM VVMLLSLLEG NVVNGMIARQ MVDMLVESSS NVEMILKFFD MFLKLKDIVG
     SEAFQDYVTD PRGLISKKDF QKAMDSQKQF SGPEIQFLLS CSEADENEMI NCEEFANRFQ
     EPARDIGFNV AVLLTNLSEH VPHDPRLHNF LELAESILEY FRPYLGRIEI MGASRRIERI
     YFEISETNRA QWEMPQVKES KRQFIFDVVN EGGEAEKMEL FVSFCEDTIF EMQIAAQISE
     PEGEPETDED EGAGAAKTRP KKPRRNPPSG DEVHGEQPAG PGGDADGEGA SEGAGEAAEG
     AGDEEEAVHE AGPGGADGAV AVTDGGPFRP EGAGGLGDMG DTTPAEPPTP EGSPILKRKL
     GVREQAGFWG FGKMGDWREE ESPAGAENGE KEEVPEPPPE PPKKQAPPSP PPKKEEAGGE
     FWGELEVQRV KFLNYLSRNF YTLRFLALFL AFAINFILLF YKVSDSPPGE DDMEGSAAGD
     VSGAGSGGGS GWGLGAGEEA EGDEDENMVY YFLEESTGYM EPALRCLSLL HTLVAFLCII
     GYNCLKVPLV IFKREKELAR KLEFDGLYIT EQPEDDDVKG QWDRLVLNTP SFPSNYWDKF
     VKRKVLDKHG DIYGRERIAE LLGMDLATLE ITAHNERKPN PPPGLLTWLM SIDVKYQIWK
     FGVIFTDNSF LYLGWYMVMS LLGHYNNFFF AAHLLDIAMG VKTLRTILSS VTHNGKQLVM
     TVGLLAVVVY LYTVVAFNFF RKFYNKSEDE DEPDMKCDDM MTCYLFHMYV GVRAGGGIGD
     EIEDPAGDEY ELYRVVFDIT FFFFVIVILL AIIQGLIIDA FGELRDQQEQ VKEDMETKCF
     ICGIGSDYFD TTPHGFETHT LEEHNLANYM FFLMYLINKD ETEHTGQESY VWKMYQERCW
     DFFPAGDCFR KQYEDQLS
//
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