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Database: UniProt
Entry: G3RNE3_GORGO
LinkDB: G3RNE3_GORGO
Original site: G3RNE3_GORGO 
ID   G3RNE3_GORGO            Unreviewed;      2274 AA.
AC   G3RNE3;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 2.
DT   28-MAR-2018, entry version 49.
DE   RecName: Full=Voltage-dependent P/Q-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
OS   Gorilla gorilla gorilla (Western lowland gorilla).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Gorilla.
OX   NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000017309, ECO:0000313|Proteomes:UP000001519};
RN   [1] {ECO:0000313|Ensembl:ENSGGOP00000017309, ECO:0000313|Proteomes:UP000001519}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Scally A.;
RT   "Insights into the evolution of the great apes provided by the gorilla
RT   genome.";
RL   Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSGGOP00000017309}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the
CC       entry of calcium ions into excitable cells and are also involved
CC       in a variety of calcium-dependent processes, including muscle
CC       contraction, hormone or neurotransmitter release, gene expression,
CC       cell motility, cell division and cell death. The isoform alpha-1A
CC       gives rise to P and/or Q-type calcium currents. P/Q-type calcium
CC       channels belong to the 'high-voltage activated' (HVA) group and
CC       are blocked by the funnel toxin (Ftx) and by the omega-agatoxin-
CC       IVA (omega-Aga-IVA). They are however insensitive to
CC       dihydropyridines (DHP), and omega-conotoxin-GVIA (omega-CTx-GVIA).
CC       {ECO:0000256|RuleBase:RU003808}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
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DR   EMBL; CABD030111848; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030111849; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030111850; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030111851; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030111852; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030111853; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030111854; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030111855; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030111856; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030111857; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 9593.ENSGGOP00000017309; -.
DR   Ensembl; ENSGGOT00000027496; ENSGGOP00000017309; ENSGGOG00000008660.
DR   GeneTree; ENSGT00830000128247; -.
DR   InParanoid; G3RNE3; -.
DR   OMA; EKDCRGK; -.
DR   OrthoDB; EOG091G0TKO; -.
DR   TreeFam; TF312805; -.
DR   Proteomes; UP000001519; Chromosome 19.
DR   Bgee; ENSGGOG00000008660; -.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR   GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.120.350; -; 4.
DR   InterPro; IPR005448; CACNA1A.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR014873; VDCC_a1su_IQ.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   InterPro; IPR027359; Volt_channel_dom_sf.
DR   Pfam; PF08763; Ca_chan_IQ; 1.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00167; CACHANNEL.
DR   PRINTS; PR01632; PQVDCCALPHA1.
DR   SMART; SM01062; Ca_chan_IQ; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001519};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAAS:SAAS00085096, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00084820,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00084701,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   TRANSMEM     76     96       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    108    128       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    163    182       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    274    296       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    424    443       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    455    475       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    550    572       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    626    650       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1180   1199       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1219   1240       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1252   1269       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1314   1336       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1426   1451       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1507   1525       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1537   1560       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1628   1646       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1724   1748       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN     1895   1929       Ca_chan_IQ. {ECO:0000259|SMART:SM01062}.
FT   COILED      304    324       {ECO:0000256|SAM:Coils}.
FT   COILED      646    682       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2274 AA;  258398 MW;  EA2575F42F335CDE CRC64;
     STPKPSAEVR KSCSGVTNTL WLFHSSSRFS SAYTSSEIAR SISTIIANCI VLALEQHLPD
     DDKTPMSERL DDTEPYFIGI FCFEAGIKII ALGFAFHKGS YLRNGWNVMD FVVVLTGILA
     TVGTEFDLRT LRAVRVLRPL KLVSGIPSLQ VVLKSIMKAM IPLLQIGLLL FFAILIFAII
     GLEFYMGKFH TTCFEEGTDD IQGESPAPCG TEEPARTCPN GTKCQPYWEG PNNGITQFDN
     ILFAVLTVFQ CITMEGWTDL LYNSNDASGN TWNWLYFIPL IIIGSFFMLN LVLGVLSGEF
     AKERERVENR RAFLKLRRQQ QIERELNGYM EWISKAEEVI LAEDETDGEQ RHPFDALRRT
     TIKKSKTDLL NPEEAEDQLA DIASVGSPFA RASIKSAKLE NSTFFHKKER RMRFYIRRMV
     KTQAFYWTVL SLVALNTLCV AIVHYNQPEW LSDFLYYAEF IFLGLFMSEM FIKMYGLGTR
     PYFHSSFNCF DCGVIIGSIF EVIWAVIKPG TSFGISVLRA LRLLRIFKVT KYWASLRNLV
     VSLLNSMKSI ISLLFLLFLF IVVFALLGMQ LFGGQFNFDE GTPPTNFDTF PAAIMTVFQI
     LTGEDWNEVM YDGIKSQGGV QGGMVFSIYF IVLTLFGNYT LLNVFLAIAV DNLANAQELT
     KDEQEEEEAA NQKLALQKAK EVAEVSPLSA ANMSIAVKEQ QKNQKPAKSV WEQRTSEMRK
     QNLLASREAL YNEMDPDERW KAAYTRHLRP DMKTHLDRPL VVDPQENRNN NTNKSRAAEP
     TVDQRLGQQR AEDFLRKQAR YHDRARDPSG SAGLDARRPW AGSQEAELSR EGPYGRESDH
     HAREGSLEQP GFWEGEAERG KAGDPHRRHV HRQGGSRESR SGSPRTGADG EHRRHRAHRR
     PGEEGPEDKA ERRARHREGS RPARGGEGEG EGPDGGERRR RHRHGAPATY EGDARREDKE
     RRHRRRKENQ GSGVPVSGPN LSTTRPIQQD LGRQDPPLAE DIDNMKNNKL ATAESAVPHG
     SLGHAGLPQS PAKMGNSTDP GPTPAIPAMA TNPQNNAASR WTPNNPGNPS NPGPPKTPEN
     SLIVTNPSGT QTNSAKTARK PDHTTVDIPP ACPPPLNHTV VQVNKNANPD PLPKKEEEKK
     EEEEDDRGED GPKPMPPYSS MFILSTTNPL RRLCHYILNL RYFEMCILMV IAMSSIALAA
     EDPVQPNAPR NNVLRYFDYV FTGVFTFEMV IKMIDLGLVL HQGAYFRDLW NILDFIVVSG
     ALVAFAFTGN SKGKDINTIK SLRVLRVLRP LKTIKRLPKL KAVFDCVVNS LKNVFNILIV
     YMLFMFIFAV VAVQLFKGKF FHCTDESKEF EKDCRGKYLL YEKNEVKARD REWKKYEFHY
     DNVLWALLTL FTVSTGEGWP QVLKHSVDAT FENQGPSPGY RMEMSIFYVV YFVVFPFFFV
     NIFVALIIIT FQEQGDKMME EYSLEKNERA CIDFAISAKP LTRHMPQNKQ SFQYRMWQFV
     VSPPFEYTIM AMIALNTIVL MMKFYGASVA YENALRVFNI VFTSLFSLEC VLKVMAFGIL
     NYFRDAWNIF DFVTVLGSIT DILVTEFGNN FINLSFLRLF RAARLIKLLR QGYTIRILLW
     TFVQSFKALP YVCLLIAMLF FIYAIIGMQV FGNIGIDVED EDSDEDEFQI TEHNNFRTFF
     QALMLLFRSA TGEAWHNIML SCLSGKPCDK NSGILTRECG NEFAYFYFVS FIFLCSFLML
     NLFVAVIMDN FEYLTRDSSI LGPHHLDEYV RVWADPCEPI ACTNPLSSPF SGRIHYKDMY
     SLLRVISPPL GLGKKCPHRV ACKRLLRMDL PVADDNTVHF NSTLMALIRT ALDIKIAKGG
     ADKQQMDAEL RKEMMAIWPN LSQKTLDLLV TPHKSTDLTV GKIYAAMMIM EYYRQSKAKK
     LQAMREEQDR TPLMFQRMEP PSPTQEGGPG QNALPSTQLD PGGALMAHES GLKESPSWVT
     QRAQEMFQKT GTWSPEQGPP TDMPNSQPNS QSVEMREMGR DGYSDSEHYL PMEGQGRAAS
     MPRLPAENQR RRGRPRGNNL STISDTSPMK RSASVLGPKA RRLDDYSLER VPPEENQRHH
     QRRRDRSHRA SERSLGRYTD VDTGLGTDLS MTTQSGDLPS KERDQERGRP KDRKHRQHHH
     HHHHHHPPPP DKDRYAQERP DHGRARARDQ RWSRSPSEGR EHMAHRQVGA AKPEGTRNPS
     ALHPPPDTPT PTHVLRHTQE CLPVIPNPTI TACRNQFKKI ITINNFKKDK KIND
//
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