ID G3RPJ8_GORGO Unreviewed; 442 AA.
AC G3RPJ8;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 71.
DE RecName: Full=26S proteasome non-ATPase regulatory subunit 6 {ECO:0000256|ARBA:ARBA00014932};
GN Name=PSMD6 {ECO:0000313|Ensembl:ENSGGOP00000017718.1};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000017718.1, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000017718.1, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000017718.1, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000017718.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the proteasome subunit S10 family.
CC {ECO:0000256|ARBA:ARBA00005717}.
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DR EMBL; CABD030021841; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_018879451.1; XM_019023906.1.
DR AlphaFoldDB; G3RPJ8; -.
DR SMR; G3RPJ8; -.
DR STRING; 9593.ENSGGOP00000017718; -.
DR Ensembl; ENSGGOT00000028820.2; ENSGGOP00000017718.1; ENSGGOG00000004430.3.
DR GeneID; 101151153; -.
DR CTD; 9861; -.
DR eggNOG; KOG0687; Eukaryota.
DR GeneTree; ENSGT00510000046608; -.
DR HOGENOM; CLU_031814_0_1_1; -.
DR InParanoid; G3RPJ8; -.
DR OMA; RLHCKVD; -.
DR OrthoDB; 166489at2759; -.
DR TreeFam; TF313819; -.
DR Proteomes; UP000001519; Chromosome 3.
DR Bgee; ENSGGOG00000004430; Expressed in testis and 6 other cell types or tissues.
DR GO; GO:0005838; C:proteasome regulatory particle; IBA:GO_Central.
DR GO; GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR Gene3D; 1.25.40.570; -; 1.
DR InterPro; IPR000717; PCI_dom.
DR InterPro; IPR019585; Rpn7/CSN1.
DR InterPro; IPR045135; Rpn7_N.
DR InterPro; IPR049549; RPN7_PSMD6_C.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR14145:SF1; 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 6; 1.
DR PANTHER; PTHR14145; 26S PROTESOME SUBUNIT 6; 1.
DR Pfam; PF01399; PCI; 1.
DR Pfam; PF10602; RPN7; 1.
DR Pfam; PF21154; RPN7_PSMD6_C; 1.
DR SMART; SM00088; PINT; 1.
DR SUPFAM; SSF48452; TPR-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50250; PCI; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Proteasome {ECO:0000256|ARBA:ARBA00022942};
KW Reference proteome {ECO:0000313|Proteomes:UP000001519}.
FT DOMAIN 246..414
FT /note="PCI"
FT /evidence="ECO:0000259|PROSITE:PS50250"
FT REGION 57..77
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 120..154
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 442 AA; 51923 MW; 1E60106CE872DF9F CRC64;
MPLENLEEEG LPKNPDLRIA QLRFLLSLPE HRGDAAVRDE LMAAVRDNNF WNRIRQEQTE
DCPPSSPSRG WHCQDWPSRK PPTSIRLCFA KPIIKRHRMP SYMAPYYEAL CKSLDWQIDV
DLLNKMKKAN EDELKRLDEE LEDAEKNLGE SEIRDAMMAK AEYLCRIGDK EGALTAFRKT
YDKTVALGHR LDIVFYLLRI GLFYMDNDLI TRNTEKAKSL IEEGGDWDRR NRLKVYQGLY
CVAIRDFKQA AELFLDTVST FTSYELMDYK TFVTYTVYVS MIALERPDLR EKVIKGAEIL
EVLHSLPAVR QYLFSLYECR YSVFFQSLAV VEQEMKKDWL FAPHYRYYVR EMRIHAYSQL
LESYRSLTLG YMAEAFGVGV EFIDQELSRF IAAGRLHCKI DKVNEIVETN RPDSKNWQYQ
ETIKKGDLLL NRVQKLSRVI NM
//
