ID G3RQ16_GORGO Unreviewed; 213 AA.
AC G3RQ16;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 53.
DE SubName: Full=Dickkopf WNT signaling pathway inhibitor 2 {ECO:0000313|Ensembl:ENSGGOP00000017888.2};
GN Name=DKK2 {ECO:0000313|Ensembl:ENSGGOP00000017888.2};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000017888.2, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000017888.2, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000017888.2, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000017888.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the dickkopf family.
CC {ECO:0000256|ARBA:ARBA00010842}.
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DR EMBL; CABD030032568; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030032569; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030032570; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030032571; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030032572; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030032573; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030032574; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030032575; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030032576; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G3RQ16; -.
DR Ensembl; ENSGGOT00000031875.2; ENSGGOP00000017888.2; ENSGGOG00000027525.2.
DR eggNOG; KOG1218; Eukaryota.
DR GeneTree; ENSGT00940000162188; -.
DR HOGENOM; CLU_080459_2_1_1; -.
DR OMA; SNYICVP; -.
DR TreeFam; TF330916; -.
DR Proteomes; UP000001519; Chromosome 4.
DR Bgee; ENSGGOG00000027525; Expressed in cerebellum and 1 other cell type or tissue.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0030178; P:negative regulation of Wnt signaling pathway; IEA:InterPro.
DR CDD; cd23015; Dkk2_Cys1; 1.
DR CDD; cd23273; Dkk2_Cys2; 1.
DR Gene3D; 2.10.80.10; Lipase, subunit A; 1.
DR InterPro; IPR006796; Dickkopf_N.
DR InterPro; IPR048500; DIKK1/2/4_C-subdom1.
DR InterPro; IPR048499; DIKK1/2/4_C-subdom2.
DR InterPro; IPR039863; DKK1-4.
DR InterPro; IPR047303; Dkk2_Cys1.
DR InterPro; IPR047302; Dkk2_Cys2.
DR PANTHER; PTHR12113:SF12; DICKKOPF-RELATED PROTEIN 2; 1.
DR PANTHER; PTHR12113; DICKKOPF3-LIKE 3; 1.
DR Pfam; PF04706; Dickkopf_N; 1.
DR Pfam; PF21481; DIKK1-2-4_C-subdom1; 1.
DR Pfam; PF21479; DIKK1-2-4_C-subdom2; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 32..82
FT /note="Dickkopf N-terminal cysteine-rich"
FT /evidence="ECO:0000259|Pfam:PF04706"
FT DOMAIN 133..162
FT /note="Dickkopf-related protein 1/2/4 C-terminal subdomain
FT 1"
FT /evidence="ECO:0000259|Pfam:PF21481"
FT DOMAIN 165..212
FT /note="Dickkopf-related protein 1/2/4 C-terminal subdomain
FT 2"
FT /evidence="ECO:0000259|Pfam:PF21479"
SQ SEQUENCE 213 AA; 23910 MW; 4AB44B39BDA06EDB CRC64;
MTSRIDYCQG LLVGVSSSGL NIIQIQCQAY PCSSDKECEV GRYCHSPHQG SSACMVCRRK
KKRCHRDGMC CPGTRCNNGI CIPVTESILT PHIPALDGTR HRDRNHGHYS NHDLGWQNLG
RPHTKMSHIK GHEGDPCLRS SDCIEGFCCA RHFWTKICKP VLHQGEVCTK QRKKGSHGLE
IFQRCDCAKG LSCKVWKDAT YSSKARLHVC QKI
//
