ID G3RQS1_GORGO Unreviewed; 810 AA.
AC G3RQS1;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 77.
DE SubName: Full=Epidermal growth factor receptor pathway substrate 8 {ECO:0000313|Ensembl:ENSGGOP00000018144.2};
GN Name=EPS8 {ECO:0000313|Ensembl:ENSGGOP00000018144.2};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000018144.2, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000018144.2, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000018144.2, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000018144.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the EPS8 family.
CC {ECO:0000256|ARBA:ARBA00006197}.
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DR EMBL; CABD030083011; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030083012; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030083013; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G3RQS1; -.
DR Ensembl; ENSGGOT00000029289.2; ENSGGOP00000018144.2; ENSGGOG00000023611.2.
DR eggNOG; KOG3557; Eukaryota.
DR GeneTree; ENSGT00940000156403; -.
DR HOGENOM; CLU_014510_0_0_1; -.
DR TreeFam; TF313069; -.
DR Proteomes; UP000001519; Chromosome 12.
DR Bgee; ENSGGOG00000023611; Expressed in adult mammalian kidney and 6 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR CDD; cd01210; PTB_EPS8; 1.
DR CDD; cd09540; SAM_EPS8-like; 1.
DR CDD; cd11764; SH3_Eps8; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR InterPro; IPR039801; EPS8-like.
DR InterPro; IPR033928; EPS8_PTB.
DR InterPro; IPR035462; Eps8_SH3.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR013625; PTB.
DR InterPro; IPR006020; PTB/PI_dom.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR041418; SAM_3.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR12287:SF21; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE SUBSTRATE 8; 1.
DR PANTHER; PTHR12287; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE SUBSTRATE EPS8-RELATED PROTEIN; 1.
DR Pfam; PF08416; PTB; 1.
DR Pfam; PF18016; SAM_3; 1.
DR Pfam; PF00018; SH3_1; 1.
DR SMART; SM00462; PTB; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 519..578
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 189..213
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 286..308
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 600..677
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 774..810
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 194..208
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 605..634
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 639..656
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 662..677
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 810 AA; 90539 MW; 08F8731ACFC83224 CRC64;
MNGHISNHPS SFGMYPSQMN GYGSSPTFSQ MDREHGSKTS AKALYGRFVY LIGYNFHLTT
FVLDRKDAMI TVDDGIRKLK LLDAKGKVWT QDMILQVDDR AVSLIDLESK NELENFPLNT
IQHCQAVMHS CSYDSVLALV CKEPTQNKPD LHLFQCDEVK ANLISEDIES AISDSKGGKQ
KRRPDALRMI SNADPGIPPP PRAPAPAPPG TVTQVDVRSR VAAWSAWAAD QGDFEKPRQY
HEQEETPEMM AARIDRDVQI LNHILDDIEF FITKLQKAAE AFSELSKRKK NKKGKRKGPG
EGVLTLRAKP PPPDEFLDCF QKFKHGFNLL AKLKSHIQNP SAADLVHFLF TPLNMVVQAT
GGPELASSVL SPLLNKDTID FLNYTVNGDE RQLWMSLGGT WMKARAEWPK EQFIPPYVPR
FRNGWEPPML NFMGATMEQD LYQLAESVAN VAEHQRKQEI KRLSTEHSSV SEYHPADGYA
FSSNIYARGS HLDQGEAAVA FKPTSNRHID RNYEPLKTQP KKYAKSRYDF VARNNSELSV
LKDDILEILD DRKQWWKVRN ASGDSGFVPN NILDIVRPPE SGLGRADPPY THTIQKQRME
YGPRPADTPP APSPPPTPAP VPVPLPPSTP APVPVSKVPA NITRQNSSSS DSGGSIVRDS
QRHRQLPVDR RKSQMEEVQD ELIHRLTIGR SAAQKKFHVP RQNVPVINIT YDSTPEDVKT
WLQSKGFNPV TVNSLGVLNG AQLFSLNKDE LRTVCPEGAR VYSQITVQKA ALEDSSGSSE
LQEIMRRRQE KISAAASDSG VESFDEGSSH
//
